Objective: To investigate the association between obesity and pulmonary function impairment, so as to provide the evidence for the early identification and intervention of chronic obstructive pulmonary disease (COPD). Methods: From 2021 to 2024, permanent residents aged 35 to 75 years in Xianju County, Zhejiang Province, were selected by convenience sampling. Initial screening was conducted using the COPD screening questionnaire, and participants with a score of ≥16 points were included in the field screening. Demographic information and disease history were collected through questionnaire surveys. Height, weight, and waist circumference were measured through physical examinations, and body mass index (BMI) was calculated. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and percentage of predicted FEV1 (FEV1%pre) were measured, and FEV1/FVC was calculated. Pulmonary function was classified as normal pulmonary function, preserved ratio impaired spirometry (PRISm), and airflow obstruction. The association between obesity and pulmonary function impairment was analyzed using a multinomial logistic regression model. Results: A total of 2 007 individuals were included, with 1 010 (50.32%) males and 997 (49.68%) females. There were 1 210 individuals aged 65 to 75 years, accounting for 60.29%. There were 930 individuals with overweight/obesity, accounting for 46.34%. There were 640 individuals with central obesity, accounting for 31.90%. There were 396, 107, and 534 individuals with general obesity only, central obesity only, and combined obesity, accounting for 19.73%, 5.33%, and 26.61%, respectively. There were 1 563 164, and 280 individuals with normal lung function, PRISm, and airflow obstruction, accounting for 77.88%, 8.17%, and 13.95%, respectively. Multinomial logistic regression analysis showed that overweight/obesity (OR=1.518, 95%CI: 1.082-2.132), central obesity (OR=1.683, 95%CI: 1.196-2.368), central obesity only (OR=2.204, 95%CI: 1.133-4.287), and combined obesity (OR=1.877, 95%CI: 1.257-2.804) were significantly associated with a higher risk of PRISm, while underweight (OR=2.724, 95%CI: 1.358-5.462) was significantly associated with a higher risk of airflow obstruction. Conclusion Obesity, especially central obesity, may increase the risk of PRISm, while underweight may increase the risk of airflow obstruction.

[Purpose]To analyze the incidence and mortality of gastric cancer in Zhejiang cancer registration areas in 2021,and trends from 2000 to 2021.[Methods]The data of gastric cancer were obtained from Zhejiang cancer registration areas.The crude incidence/mortality rates,age-specific rates,and age-standardized incidence/mortality rates by Chinese standard population(ASRC)and the world standard population(ASRW)were calculated.The temporal trends were ana-lyzed by calculating annual percentage change(APC)and average annual percentage change(AAPC).[Results]A total of 7 602 new cases and 4 178 deaths of gastric cancer were reported in 2021.The incidence and mortality rates of gastric cancer in men were significantly higher than those in women;the incidence rate in urban areas was significantly higher than that in rural areas,while the mortality was slightly lower than that in rural areas.From 2000 to 2021,the ASRC of inci-dence rate decreased from 16.80/105 to 16.08/105(without statistical significance):an upward trend was observed from 2000 to 2009,whereas a downward trend became apparent from 2009 to 2021.From 2000 to 2021 the ASRC of mortality rate decreased from 13.59/105 to 8.02/105 with an AAPC of-2.62％(P＜0.001).The decline rate of female mortality rate(AAPC=-2.68％,95％CI:-3.61％～-1.68％,P＜0.001)was slightly higher than that of male(AAPC=-2.44％,95％CI:-3.06％～-1.61％,P＜0.001).[Conclusion]In 2021,both the incidence and mortality rates of gastric can-cer in Zhejiang Province were lower than the national average in China,which ranked 6th and 4th among all types of cancer.From 2000 to 2021,the overall burden of gastric cancer in Zhejiang Province showed a downward trend.

[Purpose]To analyze the incidence and mortality of gastric cancer in Zhejiang cancer registration areas in 2021,and trends from 2000 to 2021.[Methods]The data of gastric cancer were obtained from Zhejiang cancer registration areas.The crude incidence/mortality rates,age-specific rates,and age-standardized incidence/mortality rates by Chinese standard population(ASRC)and the world standard population(ASRW)were calculated.The temporal trends were ana-lyzed by calculating annual percentage change(APC)and average annual percentage change(AAPC).[Results]A total of 7 602 new cases and 4 178 deaths of gastric cancer were reported in 2021.The incidence and mortality rates of gastric cancer in men were significantly higher than those in women;the incidence rate in urban areas was significantly higher than that in rural areas,while the mortality was slightly lower than that in rural areas.From 2000 to 2021,the ASRC of inci-dence rate decreased from 16.80/105 to 16.08/105(without statistical significance):an upward trend was observed from 2000 to 2009,whereas a downward trend became apparent from 2009 to 2021.From 2000 to 2021 the ASRC of mortality rate decreased from 13.59/105 to 8.02/105 with an AAPC of-2.62％(P＜0.001).The decline rate of female mortality rate(AAPC=-2.68％,95％CI:-3.61％～-1.68％,P＜0.001)was slightly higher than that of male(AAPC=-2.44％,95％CI:-3.06％～-1.61％,P＜0.001).[Conclusion]In 2021,both the incidence and mortality rates of gastric can-cer in Zhejiang Province were lower than the national average in China,which ranked 6th and 4th among all types of cancer.From 2000 to 2021,the overall burden of gastric cancer in Zhejiang Province showed a downward trend.

Objective:To explore the clinical significance of interleukin 6(IL 6) in pathogenesis of diabetic nephropathy by comparing the plasma and urinary level of IL 6 in patients with type 2 diabetes mellitus(DM).Methods:The plasma and urinary level of IL 6 were measured with radioimmunoassay in 20 normal controls(NC group) and 45 cases of type 2 DM,including 23 cases without albuminuria(DSM group) and 22 cases with trace albuminuria(EDN group).Results:(1)The plasms and urinary level of IL 6 markly elevated in SDM group(P