Objective To explore the effects of program of pinyin game on children with attention deficit hyperactivity disorder (ADHD) and reading disorder by a randomized controlled trial.Methods Thirty-one cases diagnosed as ADHD according to the criteria of DSM-Ⅳ and comorbid reading disorder were involved in the study.The ADHD and reading disorder children were divided into the intervention group (n=17) and the control group (n=14) by simple random sampling.One of them accepted program of pinyin game training and the other group did not make an intervention.Phonological awareness test,phonetic recognition test and reading ability test were used to evaluate the reading ability of two groups at baseline and the end of week 8,and to make intra-group and inter-group comparisons.Results At baseline,there was no significant difference in reading ability scores between the intervention group and the control group.The scores of the Phoneme deletion (4.9± 1.9 vs.5.9±2.0),Cut pinyin word (37.5(14.0,79.0) vs.50.0(17.0,99.0)),significantly increased after the intervention by the pinyin game learning software in week 8,but there was no significant difference between the two groups(t=-2.248,P=0.043;Z--3.06,P=0.002).Conclusion The intervention effect of the ADHD comorbidity reading disorder group after 8 weeks of program of pinyin game training was not significantly better than that of the control group,but it may improve the children's phonetic awareness and pinyin recognition ability.

Objective To explore the effects of program of pinyin game on children with attention deficit hyperactivity disorder (ADHD) and reading disorder by a randomized controlled trial.Methods Thirty-one cases diagnosed as ADHD according to the criteria of DSM-Ⅳ and comorbid reading disorder were involved in the study.The ADHD and reading disorder children were divided into the intervention group (n=17) and the control group (n=14) by simple random sampling.One of them accepted program of pinyin game training and the other group did not make an intervention.Phonological awareness test,phonetic recognition test and reading ability test were used to evaluate the reading ability of two groups at baseline and the end of week 8,and to make intra-group and inter-group comparisons.Results At baseline,there was no significant difference in reading ability scores between the intervention group and the control group.The scores of the Phoneme deletion (4.9± 1.9 vs.5.9±2.0),Cut pinyin word (37.5(14.0,79.0) vs.50.0(17.0,99.0)),significantly increased after the intervention by the pinyin game learning software in week 8,but there was no significant difference between the two groups(t=-2.248,P=0.043;Z--3.06,P=0.002).Conclusion The intervention effect of the ADHD comorbidity reading disorder group after 8 weeks of program of pinyin game training was not significantly better than that of the control group,but it may improve the children's phonetic awareness and pinyin recognition ability.

Objective:To assess the metabolic side effects of the following atypical antipsychoties head-to-head:amisulpride,olanzapine,aripiprazole,quetiapine,risperidone,ziprasidone.Methods:We searched the MED-LINE,EMBASE,Cochrane Library,PubMed,CNKI,Web of science,Sinomed,WANGFANG DATA databases for randomized,blineded studies comparing the above mentioned atypical antipsychoties in the treatment of schizophre-nia or related disorders.At last three reviewers extracted the data independently.All the data would be analysed with meta ananlysis and the analysis software of the RevMan 5.1 provided by Cochrane network.Results:There were 49 studies in which 45 were written in English and 4 were written in Chinese included in the review.Olanzapine pro-duced statistically significantly more weight gain than all other second-generation antipsychotics.Risperidone pro- duced significantly more weight gain than amisulpride.Olanzapine produced statistically significantly more increase in glucose levels from baseline to endpoint than all other second-genetation antipsychotics.Risperidone produced statistically significantly more increase in glucose levels from baseline to endpoint than aripiprazole,quetiap-ine.Olanzapine produced statistically significantly more increase in cholesterol than aripiprazole,risperidone and zi-prasidone.Quetiapine produced significantly more increase in cholesterol than risperidone and ziprasi-done.Risperidone produced significantly more increase in cholesterol compared to aripiprazole and ziprasidone.Conclusion:Some atypical antipsychoties lead to substantially more metabolic side effects than other a-typical antipsychoties.When choosing an atypical antipsychotic agent for an individual patient these side effects with their potential cause of secondary diseases should be weighed against efficacy and characteristics of the individual patient.