Benifits outweigh the risks for patients with autoimmune disease (AID) in remission period to be vaccinated with coronavirus disease 2019 (COVID-19) vaccines. The mRNA vaccines, inactivated vaccines, and recombinant protein subunit vaccines are safe for AID patients, whereas the safety of recombinant adenovirus vector-based vaccines is still uncertain. Some drugs for the treatment of AID may reduce the immune response of the body to the COVID-19 vaccines and affect the immune efficacy of the vaccine, which may be related to the timing of vaccination. Based on several published relevant guidelines and recommendations for the COVID-19 vaccines in AID patients, this article elaborates on vaccination problems to be paid attention to in patients with AID treated with different drugs.

Benifits outweigh the risks for patients with autoimmune disease (AID) in remission period to be vaccinated with coronavirus disease 2019 (COVID-19) vaccines. The mRNA vaccines, inactivated vaccines, and recombinant protein subunit vaccines are safe for AID patients, whereas the safety of recombinant adenovirus vector-based vaccines is still uncertain. Some drugs for the treatment of AID may reduce the immune response of the body to the COVID-19 vaccines and affect the immune efficacy of the vaccine, which may be related to the timing of vaccination. Based on several published relevant guidelines and recommendations for the COVID-19 vaccines in AID patients, this article elaborates on vaccination problems to be paid attention to in patients with AID treated with different drugs.

OBJECTIVE： To re-evaluate t he methodology quality of published systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression. METHODS ：Retrieved from Cochrane Library ，PubMed，Embase， SinoMed，CNKI，Wanfang database ，VIP，CBM and other databases ，systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression were collected during the inception to Dec. 2019. After literature screening and data extraction ， methodology quality of included literatures were evaluated by using the AMSTAR scale. RESULTS ：A total of 33 systematic reviews/Meta-analysis were included ，involving 523 RCTs and 41 020 patients. Average score of AMSTAR methodological quality evaluation was 6.76. Citalopram ，duloxetine and paroxetine were effective for the therapy of post-stroke depression ，but the conclusions about the effectiveness among antide-pressants were not consistents. The ADR incidence of Paroxetine was low. It was not clear that sertraline and citalopram may improve the neurological function of patients. CONCLUSIONS ：The methodological quality of systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression is medium ，and the conclusions about the effectiveness of antidepressants ，improvement of daily life ability and the recovery of neurological function are still controversial.

A 51-year-old male patient received an operation treatment for paranasal sinusitis induced by radiotherapy and chemotherapy of nasopharyngeal carcinoma. One oxycodone and acetaminophen tablet (each tablet contains oxycodone hydrochloride 5 mg and acetaminophen 325 mg) was given orally thrice daily before and after the operation. Pregabalin 75 mg twice daily was added because of the poor analgesic effectiveness. During the treatment, oral oxycodone hydrochloride 10 mg was given once daily by his family members for 2 days. Two days after the addition of pregabalin, the patient developed mental disorders, such as delirium, irritability, involuntary convulsions of limbs, cognitive impairment, and disorientation. All above-mentioned analgesics were discontinued and dexmedetomidine was given for pain relief and sedation. Three days later, the mental state of the patient was improved, there was no obvious delirium, the discrimination and orientation returned to normal, and dexmetomidine was discontinued. There was an obvious time correlation between the occurrence and disappearance of mental disorders and the combination of analgesic drugs. Referring to the previous literature, it was considered that the mental disorders of the patient were caused by the interaction between oxycodone and pregabalin.

A 51-year-old male patient received an operation treatment for paranasal sinusitis induced by radiotherapy and chemotherapy of nasopharyngeal carcinoma. One oxycodone and acetaminophen tablet (each tablet contains oxycodone hydrochloride 5 mg and acetaminophen 325 mg) was given orally thrice daily before and after the operation. Pregabalin 75 mg twice daily was added because of the poor analgesic effectiveness. During the treatment, oral oxycodone hydrochloride 10 mg was given once daily by his family members for 2 days. Two days after the addition of pregabalin, the patient developed mental disorders, such as delirium, irritability, involuntary convulsions of limbs, cognitive impairment, and disorientation. All above-mentioned analgesics were discontinued and dexmedetomidine was given for pain relief and sedation. Three days later, the mental state of the patient was improved, there was no obvious delirium, the discrimination and orientation returned to normal, and dexmetomidine was discontinued. There was an obvious time correlation between the occurrence and disappearance of mental disorders and the combination of analgesic drugs. Referring to the previous literature, it was considered that the mental disorders of the patient were caused by the interaction between oxycodone and pregabalin.

Objective To study the influence of different implant diameters on the implant-bone-interface stress distributions in zygomatic implant denture and illustrate the correlation between implant diameter and long-dated success rate of zygomatic implant denture.Methods Three-dimensional finite element model for maxilla and zygoma was established biomechanically in this study by spiral CT technique and finite element software technique,and zygomatic implant was simulated into the model in the first-maxillary-molar region.Zygomatic-implant-denture load cases concerning different implant diameters(3.5,4.0 and 5.0 mm) were designed and loaded vertically,obliquely.The implant-bone-interface stress distributions were analyzed by 3-D finite element method.Results The model could be observed from any angle,and had good geometric similarity compared with CT image.Stress peak values among these load cases with different diameters were compared,the load case with 3.5 mm diameter appeared the largest stress peak value,the load case with 4.0 mm diameter appeared the larger stress peak value and the load case with 5.0 mm diameter appeared the least stress peak value.As the implant diamater increased(3.5 mm→4.0 mm→5.0 mm),the compressive and tensive stress peak values of implant-bone interface in the maxillary alveolar ridge and the zygomatic area near maxillary sinus roof decreased gradually,the stress of implant-bone interface in the maxillary alveolar ridge was significantly larger than that of implant-bone interface in the zygoma area and compressive stress peak value was larger than tensive stress peak value.Conclusion The implant-bone-interface stress distributions tend towards uniformity as the implant diameter increases.Select wider-diameter implant as possible as the residual bone permitted clinically.