1.Effects of tirofiban, aspirin and clopidogrel on the incidence of major adverse cardiac events after percutaneous coronary intervention in patients with acute myocardial infarction
Chunyong ZHAO ; Guanglin WEI ; Xiaohong GAO ; Hongzhen JIN ; Xuedong ZHAO ; Xiao WANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(4):382-384
Objective To observe the effect of tirofiban,aspirin and Clopidogrel Hydrogen triple antiplatelet in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention and the effect on the incidence of major adverse cardiac events.Methods a total of 60 patients with acute myocardial infarction(AMI)in our hospital from January 2015 to-2016 in December were enrolled in this study.All patients were treated with percutaneous coronary intervention(PCI).The patients were randomly divided into control group(n=30)and observation group(n=30).The control group using clopidogrel hydrogen treatment,observation group were treated with tirofiban,aspirin and Clopidogrel Hydrogen triple antiplatelet therapy,the incidence and clinical effects of the two groups of major adverse cardiac events.Results the two groups before treatment,the platelet aggregation rate and platelet count had no statistically significant difference; no significant observation group after treatment compared 30d platelet count difference; observation group 30d after treatment,the platelet aggregation rate was lower than the control group(P<0.05); the observation group after the treatment of 30d MA-ADP on platelet drug reaction the inhibition rate is lower than the control group(P<0.05); the observation group after treatment of AA drugs 30d platelet inhibition rate,the inhibition rate of ADP,higher than that of the control group(P<0.05); the observation group after treatment,the incidence of major adverse cardiac events was 13.33%,33.33%in the control group,two groups of major adverse cardiac events was statistically significant the difference(P<0.05).Conclusion The patients with acute myocardial infarction undergoing primary percutaneous coronary intervention after treatment with tirofiban,aspirin and chlorine Pigre triple antiplatelet ideal treatment effect,can reduce the incidence of major adverse cardiac events,it is worthy of popularization and application.
2.Surveillance and risk assessment system of schistosomiasis in Jiangsu Prov-inceⅢRisk of schistosomiasis transmission in the area along the Yangtze River in Yang-zhou City
Yinping ZUO ; Daojian ZHU ; Guanglin DU ; Kai TANG ; Yucai MA ; Zhengqiu ZHANG ; Shaozhou CHEN ; Fubiao WANG ; Hongping TANG ; Jin ZHANG ; Leping SUN
Chinese Journal of Schistosomiasis Control 2016;28(4):353-357
Objective To evaluate the potential risk of schistosomiasis transmission in the area along the Yangtze River in Yangzhou City,so as to provide evidences for establishing a post?transmission surveillance system for schistosomiasis in marsh?land regions. Methods The water infectivity,floating boatmen and fishermen infection,reservoir host infection and wild feces contamination were investigated in five districts/counties along the Yangtze River in Yangzhou City,including Guangling,Hanji?ang,Jiangdu,Yizheng and Development Zone,and the transmission factors and risky characteristics were assessed after inter?ruption of schistosomiasis transmission in marshland regions. Results A total of 15 key water regions were identified in the area along the Yangtze River in Yangzhou City in 2015. A total of 1 500 sentinel mice were placed,after breeding,their overall sur?vival rate was 99.33%;1 490 were dissected,with no schistosome infection. Of the 5 576 floating boatmen and fishermen exam?ined,no schistosome infection was observed,and among the 3 566 domestic animals(including 171 cattle,1 895 sheep and 1 500 pigs),no infections were detected. During the period between January and March,2016,there were 3 200 mouse traps placed on 8 marshlands,and 62 wild mice were captured from 6 marshlands,with a capture rate of 1.94%,and no schistosome?infected wild mice were seen. In addition,there were 35 pieces of fresh wild feces captured from 7 marshlands,including 11 pieces of bovine feces(31.43%),17 pieces of sheep feces(48.57%),2 pieces of dog feces(5.71%)and 5 pieces of other feces (14.29%),and no infections were detected. Conclusions There is a low risk of schistosomiasis transmission in the area along the Yangtze River in Yangzhou City. However,the contamination of feces from bovine and sheep that are freely pastured on marshlands is a big threat to schistosomiasis control.
3.Blood Glucose Levels and Severity of Coronary Stenosis in Hypertensive Patients
Xiaoling PENG ; Zepeng LIN ; Zhiwei ZHANG ; Guanglin JIN ; Changnong PENG ; Wen WANG
Chinese Journal of Hypertension 2006;0(12):-
Objective To investigate the relationship between blood glucose levels and severity of coronary stenosis in hypertensive patients. Methods Blood pressure, fasting plasma glucose, 2 h plasma glucose, clinical features and coronary angiographic findings were analyzed retrospectively in 540 patients with essential hypertension. Acoording 2 h plasma glucose, patients were stratified into three group: group 1: 2h plasma glucose
4.Effect of Atorvastatin on Arteriosclerosis Plaque of Coronary Artery and High Sensitive C-reactive Protein in Patients with Unstable Angina
Zepeng LIN ; Guanglin JIN ; Zhiwei ZHANG
Journal of Chinese Physician 2002;0(S1):-
Objective To observe the influence of atorvastatin on serum high sensitive C-reactive protein (hs-CRP) levels and arteriosclerosis plaque of coronary artery in patients with unstable angina. Methods Thirty subjects with arteriosclerosis plaque of coronary artery were given atorvastatin 20 mg qd for 12 months.The serum levels of hs-CRP were detected before and 12 months after treatment in all patients with helical computerized tomography. Results After 12 months administration of atorvastatin, The serum levels of hs-CRP reduced( P

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