This study investigated the demographic and COVID-19 related characteristics among students from the two Niger Delta University campuses - Amassoma and Yenagoa. A cross-sectional survey was administered to 514 students drawn from the College of Health Sciences (CHS), Main Campus, and the Yenagoa Law Faculty (responses recorded separately for males and females). Chi-square tests were applied to compare gender distribution, year of study, vaccination status, understanding of COVID-19 transmission, and willingness to receive the vaccine. Although gender distribution did not differ significantly (p = 0.846), a highly significant difference in year of study (p < 0.001) was observed, indicating that academic level influences COVID-19 related knowledge and behavior. In addition, significant differences in vaccination status (p = 0.015) and willingness to vaccinate (p < 0.001) were noted. These findings underscore the need for campus-specific, culturally tailored health communication and basic health education strategies to enhance COVID-19 prevention and vaccine uptake among university communities.