Objective To evaluate the efficacy of combination therapy of cholinergic receptor blocker Tolterodine and Alpha-adrenergic receptor blocker Tamsulosin sustained-release capsules on benign prostatic hyperplasia(BPH)with overactive bladder(OAB) in elderly men.Methods A total of 97 male BPH patients aged 80 years and over(80～98 years old,mean 87.7 years old)were enrolled in this study,who met the diagnosis and treatment guidelines of OAB formulated by Chinese Urological Association and were admitted to our hospital from Jan.2015 to July.2015.Patients were randomly divided into Tamsulosin group(n＝ 51,treated with Tamsulosin) and combination group(n＝ 46,treated with Tamsulosin and Tolterodine).Results In Tamsulosin group after treatment,the international prostate symptom score(IPSS) was reduced from (18.3 ± 2.7) to (13.3 ± 3.1) (t ＝ 14.94,P ＜ 0.05),OAB symptom score(OABSS) from (9.3 ± 2.7) to (6.8 ± 1.9) (t ＝ 3.92,P ＜ 0.05),and post void residual volume(PVRV)from(36.5±32.3)ml to(16.2±12.1)ml(t＝14.98,P＜0.01).And the daily frequency of urgency,urgency incontinence and nocturia were improved in Tamsulosin group after treatment.IPSS,OABSS and PVRV were improved more significantly in combination group after treatment than in Tamsulosin group,and the daily frequency of urgency,urgency incontinence and nocturia were reduced more significantly in combination group than in tamsulosin group(t＝-5.23,-3.98,9.01,11.5,14.8,P＜0.01).While there was no significant difference in prostate volume (PV)and PVRV between the two groups after 8 weeks of treatment(t＝ 1.22,-0.94,P＞0.05).The total incidences of adverse events (mainly mouth dryness)had no significant differences between the Tamsulosingroup and the combination group(8.7％ vs.5.9％,x2 ＝99.47,P＞0.05).No acute urinary retention was found in the two groups.Conclusions The combination therapy of Tamsulosin and Tolterodine has better efficacy and safety than single Tamsulosin application in the treatment of BPH with OAB in elderly men.

Objective To investigate the clinical efficacy of atmospheric oxygen coupled with hyperbaric oxygen (HBO) in the treatment of neurologic impairment with hemorheology in senile patients following hypertensive cerebral infarction.Methods Ninety-three senile patients with hypertensive cerebral infarction treated in our hospital were recruited as research subjects,and were divided into the observation group (48 cases) and the control group (45 cases) in accordance with different treatment methods.The observation group was treated with atmospheric oxygen couple with hyperbaric oxygen therapy,while the control group was only given HBO therapy.Then,differences in the clinical efficacy and changes in hemorheology were closely observed and compared between the 2 groups.Results Total efficacy of the observation group (97.9％) was significantly higher than that of the control group (82.2％),and statistical significance could be noted,when comparisons were made between them (P ＜ 0.05).There was no statistical significance in neurological deficit scores and Barthel scores for the 2 groups before treatment (P ＞ 0.05).However,those scores of the observation group after treatment [(7.4 ±4.1),(56.3 ± 15.2)] were significantly superior to those of the control group [(11.2 ± 5.4),(43.3 ± 10.7)],and statistical significance could be seen when comparisons were made between them(P ＜ 0.05).Following treatment,the parameters of blood pressure and changes in hemorheology of the observation group were significantly superior to those of the control group,with statistical significance (P ＜ 0.05).Conclusions In the treatment of neurologic impairment with hemorheology of senile patients,atmospheric oxygen coupled with HBO could achieve better clinical efficacy,and this treatment regimen was of positive significance for the recovery of neural function and improvement of life quality of the patients.

Objective To investigate the clinical efficacy of atmospheric oxygen coupled with hyperbaric oxygen (HBO) in the treatment of neurologic impairment with hemorheology in senile patients following hypertensive cerebral infarction.Methods Ninety-three senile patients with hypertensive cerebral infarction treated in our hospital were recruited as research subjects,and were divided into the observation group (48 cases) and the control group (45 cases) in accordance with different treatment methods.The observation group was treated with atmospheric oxygen couple with hyperbaric oxygen therapy,while the control group was only given HBO therapy.Then,differences in the clinical efficacy and changes in hemorheology were closely observed and compared between the 2 groups.Results Total efficacy of the observation group (97.9％) was significantly higher than that of the control group (82.2％),and statistical significance could be noted,when comparisons were made between them (P ＜ 0.05).There was no statistical significance in neurological deficit scores and Barthel scores for the 2 groups before treatment (P ＞ 0.05).However,those scores of the observation group after treatment [(7.4 ±4.1),(56.3 ± 15.2)] were significantly superior to those of the control group [(11.2 ± 5.4),(43.3 ± 10.7)],and statistical significance could be seen when comparisons were made between them(P ＜ 0.05).Following treatment,the parameters of blood pressure and changes in hemorheology of the observation group were significantly superior to those of the control group,with statistical significance (P ＜ 0.05).Conclusions In the treatment of neurologic impairment with hemorheology of senile patients,atmospheric oxygen coupled with HBO could achieve better clinical efficacy,and this treatment regimen was of positive significance for the recovery of neural function and improvement of life quality of the patients.

Objective , To investigate the influence of blood pressure variability on cerebral infarction in older men. Methods Ambulatory blood pressure was measured in 1527 elderly men ( older than 65 yrs) with atherosclerosis. All cases were divided into 2 groups: Six hundred and seven patients with cerebral infarction ( group A)and 920 patients without cerebral infarction ( group B). Smooth curve method was used to analyze each patient's ambulatory blood pressure data and the trend of each patient's blood pressure curve was portrayed. The differences between the actual blood pressure and the blood pressure on the curve was defined as blood pressure variability,and the blood pressure variability between the 2 groups was compared. Results The systolic blood pressure variability in 24 hours in group A was significantly higher than that in group B( [8.4'±2. 2]mm Hg vs [ 8.0 ± 2. 0 ] mm Hg, P ＜ 0. 01 ), especially for the systolic blood pressure variability in daytime( [ 8. 2 ± 2. 2 ] mm Hg vs [ 7. 8 ± 2. 1 ] mm Hg, P ＜ 0. 01 ). However, the systolic blood pressure variability at night was not significantly different between the 2 groups( [ 8.9 ± 3. 9 ] mm Hg vs [ 8. 7 ± 3.7 ] mm Hg,P ＞ 0. 05 ). There were no significant difference between the diastolic blood pressure of 24 hours( [5. 5 ± 3.8 ] mm Hg vs [5.5 ± 1.5 ]mm Hg,P ＞0. 05),during daytime([5.4 ± 1.5]mm Hg vs [5.3 ± 1.4] mm Hg,P ＞0.05)and nighttime ( [ 6. 1 ± 2.7 ] mm Hg vs [ 6. 1 ± 2. 6 ] mm Hg, P ＞ 0. 05 ). Conclusion In elderly men with atherosclerosis,cerebral infarction was closely related to systolic blood pressure variability,but independent of nighttime systolic blood pressure and diastolic blood pressure variability.