Objective To investigate the neurological function recovery and prognosis by comparing robot-guided puncture drainage and medicine treatment for small to moderate volume(15-30 ml)hypertensive cerebral hemorrhage in the basal ganglia.Methods Clinical data of 68 patients with small to moderate volume hypertensive cerebral hemorrhage in the basilar ganglia treated in our department from January 2022 to January 2024 were retrospectively analyzed.According to the treatment methods,they were divided into operation group and medicine group,in which the operation group(n=30)received robot-guided puncture and drainage treatment and the medicine group(n=38)received simple medicine treatment.Parameters of the two groups were compared,including time for hematoma to dissipate,length of hospital stay,hospital cost,duration of mannitol use,pulmonary infection rate,National Institutes of Health Stroke Scale(NIHSS)score and Scandinavia Stroke Scale(SSS)score at time immediately after admission and 2 weeks later,and modified Rankin Scale(mRS)score at the time immediately after admission and 3 months later.Results There were no significant differences in the length of stay,duration of mannitol use,and pulmonary infection rate between the two groups(P＞0.05).The hematoma dissipation time was 10.0(8.5,13.0)din the operation group and 28.5(25.0,35.0)din the medicine group,which had significant difference(Z=-4.285,P=0.000).The hospital cost was(77 786.5±21 763.0)yuan in the operation group and(31 843.5±14 514.3)yuan in the medicine group,which had significant difference(t=5.922,P=0.000).At 14 d after treatment,the NIHSS score in the operation group(8.5±2.7)points was significantly lower than that in the medicine group[(12.0±1.7)points,t=-4.192,P=0.000],and the SSS score in the operation group(28.7±7.2)points was significantly higher than that in the medicine group[(24.2±3.5)points,t=2.164,P=0.041].At 3 months after treatment,the mRS score of the operation group was 3.0(2.0,4.0)points,significantly lower than that of the medicine group[4.0(4.0,4.2)points,Z=-2.508,P=0.012].Conclusion For small to moderate volume hypertensive cerebral hemorrhage in the basal ganglia,robot-guided minimally invasive puncture and drainage treatment can accelerate the dissipation time of hematoma and improve the neurological function and prognosis of patients as compared to medicine treatment.

Objective To investigate the neurological function recovery and prognosis by comparing robot-guided puncture drainage and medicine treatment for small to moderate volume(15-30 ml)hypertensive cerebral hemorrhage in the basal ganglia.Methods Clinical data of 68 patients with small to moderate volume hypertensive cerebral hemorrhage in the basilar ganglia treated in our department from January 2022 to January 2024 were retrospectively analyzed.According to the treatment methods,they were divided into operation group and medicine group,in which the operation group(n=30)received robot-guided puncture and drainage treatment and the medicine group(n=38)received simple medicine treatment.Parameters of the two groups were compared,including time for hematoma to dissipate,length of hospital stay,hospital cost,duration of mannitol use,pulmonary infection rate,National Institutes of Health Stroke Scale(NIHSS)score and Scandinavia Stroke Scale(SSS)score at time immediately after admission and 2 weeks later,and modified Rankin Scale(mRS)score at the time immediately after admission and 3 months later.Results There were no significant differences in the length of stay,duration of mannitol use,and pulmonary infection rate between the two groups(P＞0.05).The hematoma dissipation time was 10.0(8.5,13.0)din the operation group and 28.5(25.0,35.0)din the medicine group,which had significant difference(Z=-4.285,P=0.000).The hospital cost was(77 786.5±21 763.0)yuan in the operation group and(31 843.5±14 514.3)yuan in the medicine group,which had significant difference(t=5.922,P=0.000).At 14 d after treatment,the NIHSS score in the operation group(8.5±2.7)points was significantly lower than that in the medicine group[(12.0±1.7)points,t=-4.192,P=0.000],and the SSS score in the operation group(28.7±7.2)points was significantly higher than that in the medicine group[(24.2±3.5)points,t=2.164,P=0.041].At 3 months after treatment,the mRS score of the operation group was 3.0(2.0,4.0)points,significantly lower than that of the medicine group[4.0(4.0,4.2)points,Z=-2.508,P=0.012].Conclusion For small to moderate volume hypertensive cerebral hemorrhage in the basal ganglia,robot-guided minimally invasive puncture and drainage treatment can accelerate the dissipation time of hematoma and improve the neurological function and prognosis of patients as compared to medicine treatment.

OBJECTIVE: To investigate the enhancement of macrophage chemotaxis in patients with knee osteoarthritis (KOA) and its correlation with the disease severity. METHODS: Eighty patients with KOA admitted from July 2019 to June 2022 were enrolled as the observation group and divided into 29 cases of moderate group, 30 cases of severe group and 21 cases of extremely severe group. At the same time, 30 healthy subjects were included as the control group. The gene expressions of NF-κB, CXC chemokine receptor 7 (CXCR7) and CXC chemokine ligand 12 (CXCL12) in macrophages of each group were analyzed. Visual analogue scale(VAS) was used to evaluate the degree of joint pain. Joint function was evaluated by knee Joint Society Scoring system(KSS). Finally, data analysis was carried out. RESULTS: The expression levels of NF-κB, CXCR7 and CXCL12 in moderate group, severe group and extreme recombination group were higher than those in control group. The VAS, the expression of NF-κB, CXCR7 and CXCL12 in the severe group and the extreme recombination group were higher than those in the moderate group, whereas KSS was lower than that in the moderate group. The VAS, expression levels of NF-κB, CXCR7 and CXCL12 in the extremely severe group were higher than those in the severe group, and KSS was lower than that in the severe group (all P<0.01). The expression levels of NF-κB, CXCR7 and CXCL12 in macrophages were positively correlated with VAS score, but negatively correlated with KSS(all P<0.01). The expression levels of NF-κB, CXCR7 and CXCL12 in macrophages were positively correlated with the severity of disease. After excluding the influence of traditional factors (gender, age and disease duration), multiple linear regression analysis further showed that the expression levels of NF-κB, CXCR7 and CXCL12 were still positively correlated with the severity of disease(all P<0.01). CONCLUSION The chemotaxis of macrophages in patients with KOA increased with the aggravation of the disease, and was related to the degree of pain and function impairment.
Humans ; Osteoarthritis, Knee/genetics* ; Chemotaxis/genetics* ; NF-kappa B/metabolism* ; Macrophages/metabolism* ; Receptors, CXCR/metabolism* ; Patient Acuity

In order to explore the teaching methods of biochemistry experiment teaching,Biochemistry department of Wannan medical college adopts PBL and case-based teaching contrast to lecture based learning in exerimental course,to evaluate teaching effect by analyzing questionnaire survey associated examination results.It is shown that PBL and case-based teaching can get good teaching effect.

Objective To discuss the diagnostic value of peritoneal effusion detection by emergency-ultrasound in patients with closed abdominal injury. Method From August 2006 to June 2009,212 patients with closed abdominal injury were studied to evaluate peritoneal effusion detection by emergency ultrasound. Results of 212 patients,peritoneal effusion frequency rate was 78.8%( 167/212), meanwhile,abdominal paracentesis confirmation ratio was only 46.2%(98/212). In the follow-up, 13 patients with injuried hollow viscera and 1 patient with rupture of kidney showed peritoneal effusion. The volume of abdominal fluid was increasing in 17 patients,which needed to be managed by surgery. The accuracy rates were respectively 78.3%( 112/143) and 36.1%(13/36) in the solid organs and the hollow organs. Conclusion During the course of diagnosis and treatment in closed abdominal injury,peritoneal effusion monitoring by ultrasound should be used routinely, which can help to decrease the rate of misdiagnosis and avoid delayed treatment.

Objective To evaluate the effects of 3-dimensional conformal radiation therapy(3DCRT) in form of local control and survival of rectal cancer patients. Methods Forty-two patients with rectal cancer were irradiation by 3DCRT. They first received 40 Gy with larger field, at 1.8-2.0 Gy/f, 1 fraction qd, then followed by a boost of 24-27 Gy with reduced field, at 3.0-4.0 Gy/f, 1 fraction qod, to a total dose of 0,64-67 Gy. Results The 1-,2-,3-year survival rates were 83.3% ,64.3% and 45.2% .The 1-,2-,3-year local recurrence rates were 2.4%,11.9% and 23.9%. Conclusion Three-dimensional conformal radiotherapy is able to prolong the survival and improve the life quality of patients with rectal cancer.