OBJECTIVE To evaluate the efficacy and safety of intranasal corticosteroids （INCS） combined with oral H1- antihistamine （AH） in the treatment of allergic rhinitis. METHODS A comprehensive literature search was conducted in PubMed， Embase， CNKI， and VIP database to collect randomized controlled trial （RCT） that INCS combined with AH （experimental group） versus INCS （control group） in the treatment of allergic rhinitis from the inception to December 31， 2024. After study selection， data extraction， and quality assessment， a meta-analysis was performed by using RevMan 5.3 software. RESULTS A total of 12 RCTs were included in the meta-analysis， with a total of 1 842 patients. Results of meta-analysis showed that， compared with the control group， patients in the experimental group had a greater reduction in sneezing scores， rhinorrhea scores， nasal congestion scores， nasal itching scores， total nasal symptom scores， total ocular symptom scores， and rhinoconjunctivitis quality of life questionnaire scores （P＜0.05）. The incidence of headache was lower in the experimental group （P＜0.05）； whereas there were no significant differences between the two groups in the incidence of nosebleed， dryness of the mouth and nose， drowsiness， fatigue， and total adverse events （P＞0.05）. CONCLUSIONS Compared with INCS monotherapy， the combination of INCS and oral AH provides superior efficacy and safety in the treatment of allergic rhinitis.

Objective To assess the occupational health literacy (OHL) level and health education needs among workers in chemical enterprises in Fuling District, Chongqing City. Methods A total of 8 209 workers from 18 chemical enterprises in Fuling District, Chongqing City were selected as the research subjects using the judgment sampling method. The Occupational Health Literacy Survey Questionnaire designed by the research team was used to survey OHL levels and health education needs in workers. Results The OHL level of the research subjects was 62.1% (5 101/8 209). Multivariable logistic regression analysis showed that the OHL level of male workers was higher than that of females (P<0.01); higher OHL was also associated with higher education level, higher personal monthly income and smaller enterprises of workers (all P<0.01); production team leaders, safety production/technical management personnel, and administrative/logistics staff all had higher OHL levels than front-line operators (all P<0.05); and workers who participated in occupational health knowledge training more frequently had higher OHL levels (all P<0.05). The result of health education needs investigation showed that 97.8% of the research subjects believed that occupational health knowledge training provided by their workplaces could improve workers' OHL levels; the main channels for workers obtaining occupational health knowledge and information on workplace hazards were “employer-organized occupational health training” and “warning signs and labels”, accounting for 93.9% and 90.9%, respectively; 59.9% of workers preferred to acquire occupational health knowledge through “training or publicity organized by their workplace”. However, a current problem with occupational health knowledge publicity is its lack of diverse formats. Conclusion The OHL level of workers in chemical enterprises in Fuling District, Chongqing City is influenced by gender, educational level, enterprise size, job position, monthly personal income, and training status. The formats of occupational health knowledge publicity should be optimized.

Background As a key to economic and social development, occupational groups with low levels of occupational health literacy (OHL) are considered vulnerable groups with high risks of work-related diseases and injuries. Therefore, improving the OHL of these groups is of great significance in reducing the burden on public health. Objective To master the four dimensional OHL levels and influencing factors of the key groups in Fuling District, Chongqing, and provide a basis for formulating health education programs for occupational groups in the future. Methods The Occupational Health Literacy Questionnaire of Key Populations was distributed online to investigate the key occupational groups in Fuling District through stratified cluster sampling. The survey collected data on basic demographic information, legal knowledge of occupational health, basic knowledge of occupational health protection, basic skills of occupational health protection, and healthy working style and behavior. Univariate analysis, logistic regression, and nomogram were used to analyze the above data. Results This survey distributed 4824 questionnaires, of which 4677 were valid, with a recovery rate of 97.0%. The dimensional OHL levels of key occupational groups in Fuling District from high to low were: healthy working style and behavior (79.1%), basic knowledge of occupational health protection (78.4%), legal knowledge of occupational health protection (43.3%), and basic skills of occupational health protection (37.6%). The results of logistic regression showed that the occupational health legal knowledge levels in the groups of high school/vocational high school/technical secondary school and above (reference: primary school and below) (OR=1.47, 95%CI: 1.05, 2.05), ≥3000 yuan of monthly income (reference: <3000 yuan of monthly income) (OR=1.39, 95%CI: 1.06, 1.84), and medium enterprises (reference: micro enterprises) (OR=1.84, 95%CI: 1.29, 2.63) were higher; the occupational health legal knowledge level in the electricity, heat, gas, and water production and supply industry was lower than that in the mining industry (OR=0.68, 95%CI: 0.47, 0.97); the basic knowledge levels of occupational health protection in the groups of ≥ 3 years of service (reference: < 3 years of service) (OR=0.78, 95%CI: 0.65, 0.94) and medium enterprises (reference: large enterprises) (OR=0.78, 95%CI: 0.64, 0.95) were lower; the basic knowledge level of occupational health protection in the ethnic minorities was higher than that in the Han ethnic group (OR=1.73, 95%CI: 1.04, 2.87); the occupational health protection basic skill level in the group of ≥ 3 years of service (reference: < 3 years of service) (OR=0.69, 95%CI: 0.60, 0.79) was higher; the level of healthy working style and behavior in the group of ≥ 11 years of service (reference: < 3 years of service) (OR=0.73, 95%CI: 0.59, 0.89) was lower; the level of healthy working style and behavior in the group of high school/vocational high school/technical secondary school and above (reference: primary school and below) (OR=1.60, 95%CI: 1.15, 2.23) was higher. The nomogram showed that educational level and monthly income had the greatest impact on the occupational health legal knowledge level; length of service had the greatest impact on the basic knowledge of occupational health protection level and the healthy working style and behavior level. Conclusion In the future, the focus of health education and health promotion in Fuling District should be implemented to improve the basic skills of occupational health protection and the legal knowledge of occupational health, especially for workers with low education, low income, from micro enterprises, and on the job, so as to improve their skills of occupational health protection and legal knowledge, and to control the occurrence of occupational or work-related diseases.

Background: Urea capsule is retained in esophagus during

To explore the clinical effect, safety and effectiveness of ultrasound-guided rhomboid intercostal and subserratus plane (RISS) block for postoperative analgesia after minimally invasive McKeown esophagectomy (MIE-McKeown), and provide new ideas for the selection of postoperative analgesia programs for minimally invasive esophageal cancer surgery patients.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause acute respiratory distress syndrome, hypercoagulability, hypertension, and multiorgan dysfunction. Effective antivirals with safe clinical profile are urgently needed to improve the overall prognosis. In an analysis of a randomly collected cohort of 124 patients with COVID-19, we found that hypercoagulability as indicated by elevated concentrations of D-dimers was associated with disease severity. By virtual screening of a U.S. FDA approved drug library, we identified an anticoagulation agent dipyridamole (DIP) , which suppressed SARS-CoV-2 replication . In a proof-of-concept trial involving 31 patients with COVID-19, DIP supplementation was associated with significantly decreased concentrations of D-dimers ( < 0.05), increased lymphocyte and platelet recovery in the circulation, and markedly improved clinical outcomes in comparison to the control patients. In particular, all 8 of the DIP-treated severely ill patients showed remarkable improvement: 7 patients (87.5%) achieved clinical cure and were discharged from the hospitals while the remaining 1 patient (12.5%) was in clinical remission.

To explore the role of autophagy in hair follicle cycle and whether 3-methyladenine(3-MA)could promote hair regeneration in C57BL/6 mice through inhibiting autophagy flux, hair regeneration model of C57BL/6 mice was induced on the dorsal skin by depilation, and 3-MA was intraperitoneally injected to investigate hair regrowth, meanwhile vehicle and rapamycin(RAPA)were used as the controls. Results showed that 3-MA could obviously promote hair regrowth in depilated C57BL/6 mice. Furtherly, haematoxylin-eosin staining, immunohistochemical staining, immunofluorescence and Western blot tests were used to investigate the autophagy signals and the cell proliferation. Results showed that the expression of Beclin1 and LC3B II/I ratio were significantly decreased. Expression of P62 and Ki67 were increased, as well as the CD34 and CD49f double-labeled hair follicle stem cells were obviously increased inside bulge areas in 3-MA group, while contrarily in RAPA group. These results affirmed 3-MA, an autophagy inhibitor, could promote hair regeneration in depilated C57BL/6 mice by facilitating the transformation of hair follicle from telogen to anagen. 3-MA and other analogous autophagy inhibitors probably have a potential usage in future therapy in human telogen effluvium diseases.

Objective: To compare the clinical and imaging characteristics of traumatic acute subdural hematoma acute subdural hematoma with rapid resolution and those without rapid resolution. Methods: A retrospective case-control analysis was conducted on the clinical data of 60 traumatic acute subdural hematoma patients with hematoma thickness≥5 mm admitted to Second Affiliated Hospital of Shantou University Medical College from January 2011 to May 2018. There were 37 males and 23 females, aged 18-80 years [(47.0±16.9)years]. There were 27 patients in the rapid resolution group and 33 patients in the non-rapid resolution group. Coagulation function [prothrombin time (PT) and international normalized ratio (INR)] on admission, hospital stay, Glasgow outcome scale (GOS), and brain CT results were compared between the two groups. Results: The PT and INR values in the rapid resolution group were (11.9±2.1)s and 1.1±0.2 respectively, while those in the non-rapid resolution group were (10.8±1.0)s and 1.0±0.1 respectively, with significant differences (P<0.05). There was no significant difference in hospital stay and GOS between the two groups (P>0.05). The thickness of subdural hematoma of the two groups in the first CT scanning was (8.2±2.3)mm and (7.3±1.8)mm, respectively, with no statistically significant difference (P>0.05). In the second CT scanning, the hematoma thickness in the rapid resolution group was significantly lower than that in the non-rapid resolution group [(2.7±1.9)mm vs. (6.6±2.1)mm] (P<0.01). The incidence of low density zone between the hematoma and intracranial plate was statistically higher in rapid resolution group than that in non-rapid resolution group (93% vs. 36%) (P<0.01). The incidence of subarachnoid hemorrhage(SAH) increase was significantly higher in rapid resolution group than that in non-rapid resolution group in the second CT scan (74% vs. 15%) (P<0.01). The conversion rate of acute subdural hematoma to subacute or chronic subdural hematoma was 4% in the rapid resolution group, which was significantly lower than 18% in the non rapid resolution group (P<0.05). Conclusions The abnormal coagulation function and low density zone indicated by CT are two important indicators of rapid resolution in patients with traumatic acute subdural hematoma. The risk of conversion from acute into subacute or chronic subdural hematoma is lower in rapid resolution of traumatic acute subdural hematoma, suggesting that rapid resolution may be one of the prognostic indicators of ASDH patients.

Objective To make the chromosome karyotype analysis of 130 patients with leukemia by using the improved chromosome short-term culture method.Methods We optimized the main factors with a single factor gradient experiment in short-term culture of bone marrow chromosome, including colchicines concentration, duration of action of colchicines,and hypotonic time.On this basis,we conducted the three-factors and three-level orthogonal experiment to achieve improved bone marrow chromosome preparation system,which was later applied in 130 patients with leukemia in our hospital.Results The orthogonal experiment results showed that the optimum conditions were colchicines concentration of 0.07 μg/mL,colchicines action time of 80 min,and hypotonic time of 35 min during the preparation of the bone marrow chromosome.Using this method,the chromosome preparation success rate reached 97.69% and the detection rate of abnormal karyotype reached 82.3% in the chromosome karyotype analysis.Conclusion Bone marrow chromosome preparation system with colchicines concentration of 0.07 μg/mL and colchicines action time of 80 min,and hypotonic time of 35 min is worthy of clinical promotion.

This study was designed to examine the effects of autophagy on the lipopolysaccharide(LPS)-induced acute lung injury (ALI)and to analyze the possible mechanism.Kunming mice of clean grade were randomly divided into 6 groups:control group(saline;ip);model group(LPS 10 mg/kg;ip);RAP group(rapamycin 6 mg/kg;ip);RAP+LPS group (RAP 6 mg/kg and LPS 10 mg/kg;ip);3-MA group (3-methyladenine 300 μg/kg;ip);and 3-MA+LPS group (3-MA 300 μg/kg and LPS 10 mg/kg;ip).6 h after LPS injection;mortality was checked.Neutrophil aggregation;and the expressions of TNF-α;LC3 and P62 in lung tissue were checked by fluo-rescence microscopy and Western blot.The results revealed a higher mortality;neutrophil infiltration and TNF-αexpression and significantly increased levels of autophagy marker LC3-II and P62 in LPS group;in RAP+LPS group;pretreatment with RAP notably reversed LPS-induced neutrophil infiltration and TNF-αexpression;LC3-II were further slightly increased;while P62 was significantly decreased;in 3-MA+LPS group;pretreatment of 3-MA slightly decreased LC3-II expression;P62;neutrophil infiltration and TNF-αremained almost the same to those in LPS group.These data suggesed that;in sepsis;autophagy flux in the lung tissue is partially blocked;and RAP help to alleviate LPS-induced lung injury;which might through promoting autophagosome maturation;smoothing autophagy flux;and eventually to mitigate pulmonary inflammation.