Objective To explore the rules of medication by Professor Liu Maocai in the treatment of acute hemorrhagic stroke through data mining.Methods Chinese medicine prescriptions for acute hemorrhagic stroke treated by Professor Liu Maocai from 2010 to 2020 were collected,and then the frequency of the medicinal properties and flavors as well as the meridian tropism was counted.In addition,FangNet platform software was used to analyze the grading of frequency weights of the herbal medicines,co-occurrence and mutual exclusion of the herbal medicines,and clustering of the herbal medicines in the prescriptions.Results A total of 52 prescriptions involving 94 herbal medicines were included for the analysis.The herbal medicines were usually cold in nature and bitter in flavor,and frequently had the meridian tropism of liver meridian.The analysis of the grading of frequency weights yielded 20 driver herbs,namely Sarcandrae Herba,Polygoni Cuspidati Rhizoma,Acori Tatarinowii Rhizoma,Uncariae Ramulus cum Uncis,Scutellariae Radix,Ilex Pubescens Radix,Bambusae Concretio Silicea,Moutan Cortex,Paeoniae Radix Rubra,Saigae Tataricae Cornu,Houttuyniae Herba,Persicae Semen,Carthami Flos,Leonuri Herba,Polygalae Radix,Glycyrrhizae Radix et Rhizoma,Achyranthis Bidentate Radix,Gastrodiae Rhizoma,Curcumae Radix,and Bambusae Caulis in Taenia.The co-occurrence analysis of the herbal medicines yielded nine groups of herbal co-occurrence combinations,e.g.,Paeoniae Radix Rubra-Moutan Cortex,Fersicae semen-Carthami Flos,and Scutellariae Radix-Polygoni Cuspidati Rhizoma were obtained.Four herbal combinations were obtained after cluster analysis.Conclusion For the treatment of patients with acute hemorrhagic stroke,Professor Liu Maocai often adopts herbal medicines being cold and cool in nature and bitter in flavor,and with the meridian tropism of liver meridian.The prescriptions for acute hemorrhagic stroke are usually composed of herbal medicines for clearing heat and calming liver,removing stasis and eliminating phlegm,unblocking bowels and inducing resuscitation.For acute hemorrhagic stroke has the manifestations characterized by"fu-viscera excess being the most commonly syndrome",and it is recommended to use herbal medicines for unblocking bowels in the acute stage.

Objective To investigate the safety and efficacy of mechanical thrombectomy (MT) compared with In?tra-arterial Thrombolysis (IAT) treatment in patients with severe acute ischemic stroke (AIS) caused by large cerebral ar?tery occlusion. Method The patients with AIS caused by large cerebral artery occlusion and underwent MT or IAT from 2005 May to 2014 May was included. A retrospective analysis was conducted on the onset to emergency(OTE)time, emergency to acupuncture(ETA)time, acupuncture to recanalization (ATR) time, stroke severity as measured by the Na?tional Institutes of Health Stroke Scale (NIHSS) score, and site of arterial occlusion on magnetic resonance angiography (MRA). A comparison was made between MT and IAT patients in rates of recanalization, symptomatic intracranial bleed?ing (SIB), mortality, and functional outcome. Three-month favourable outcome was defined as a modified Rankin Scale (mRS) score≤2. Result One hundred and two AIS patients were treated with MT and 50 with IAT. There was no differ?ence between MT and IAT groups with regard to demographics, onset NIHSS score (13.37±6.95 vs. 12.70±6.11;P=0.572) and discharge NIHSS score (8.40 ± 6.69 vs. 7.53 ± 7.28, P= 0.522) and the change of NIHSS score (3.87 ± 7.14 vs. 4.26 ± 5.42, P=0.766). There were significantly differences between MT and IAT groups in the OTE time (Median 300 min vs. 120 min,Z=-5.704,P=0.000) , ATR time (Median 30 min vs. 65 min,Z=-5.011,P=0.001) ,recanalization (91.2%vs. 60.0%,P =0.01),the rate of AIB(21.7% vs. 36.0%,P =0.046),3-month mortality (16.6% vs. 26.0%,P =0.043). The above parameters were better in MT group than in the IAT group. There were no significant differences between MT and IAT groups in the rate of SIB (12% vs. 16%,P =0.055), the NIHSS change(Median 3 vs. 4,Z =-0.236,P =0.823) and mRS score on 90d ( 48.2%vs. 46.0%, P=0.823). MT patients had significantly higher percentages of stent use (22.5%vs. 8%,P=0.018) . The Recanalization for ICA(81.8%vs. 55.6%,P=0.048),BA(93.1%vs. 55.6%,P=0.032)and MCA( 97.5% vs. 60.0%,P =0.026)was higher in MT group than in IAT group .The SIB rate for ICA(13.8% vs. 33.3%,P =0.000),BA(13.8%vs. 33.3%,P=0.000)was lower in MT group than in IAT group . The mortality rate of was significant?ly lower in MT than in IAT group for MCA (2.5%vs. 20.0%,P=0.000) . the good outcome rate for BA was higher in MT group than in IAT group(41.3%vs. 22.2%,P﹤0.01). Conclusions Compared to IAT,MT can provide broader time win?dow,higher recanalization rate and better outcome in patients with severe acute ischemic stroke (AIS) caused by large ce?rebral artery occlusion.

This article was aimed to study the correlation of traditional Chinese medicine (TCM) syndromes with re-gion factor in the first year after first ischemic stroke. Cross-sectional study was applied in the data collection of TCM four examinations among subjects in China using the same observing rating scale. The results showed that sub-jects of North China were mainly presented with the syndromes of qi-deficiency, internal-heat and phlegm-damp;subjects of Middle China were mainly presented with the syndrome of q i-deficiency; and subjects of East and South China were mainly presented with the syndrome of qi-deficiency and blood-stasis. The proportion of internal-heat was obviously higher in North China than in South China; that of phlegm-damp was remarkably higher in North Chi-na than in Middle and East China; and that of blood-stasis was significantly lower in Middle China than in East and South China. It was concluded that the distribution of internal-heat and blood-stasis was significantly affected by factor of region. Patients in North and South China differed greatly in TCM syndrome. Internal-heat is the main syn-drome in North China, while blood-stasis in South China.

This article was aimed to study the correlation among traditional Chinese medicine (TCM) syndrome elements in the first year after ischemic stroke. Data of TCM four examinations were collected among subjects all over China by cross-sectional study, using the same observing rating scale. The results showed that internal-heat, internal-wind and phlegm-damp syndrome were risk factors with obvious positive correlation. On the contrary, blood-stasis, internal-heat and qi-deficiency syndrome were in obvious negative correlation. But syndrome of yin-deficiency had no significant correlation with other syndrome elements. It was concluded that there were remarkable positive correlations on excess syndromes, such as wind, fire and phlegm. The syndromes of excess in the branch are easily to be combined.