Objective:To systematically review the clinical value of Golgi protein 73 (GP73) in intrahepatic cholangiocarcinoma (ICC) diagnosis.Methods:Online databases were searched by researchers on CNKI, VIP, Wanfang, PubMed, Embase, and Cochrane library. Clinical studies related to the diagnosis of ICC by GP73 value were included according to inclusion and exclusion criteria. Study data were collected, and then methodological quality was evaluated. Both RevMan 5.3 software and Meta-Disc 1.4 software were used for pooled analysis to investigate the difference of GP73 value between the ICC group and non-ICC group, as well as the diagnostic efficiency of GP73 for ICC.Results:A total of 12 studies comprising 3 723 patients (2 345 males and 1 378 females, aged 18-85 years) were included in the meta-analysis. Among these, 537 cases were definitively diagnosed as ICC, while the remaining 3 186 non-ICC cases included 600 benign liver tumors or healthy controls, 1 795 hepatocellular carcinomas (HCC), and 791 cases of liver cirrhosis. Pooled analysis of serum GP73 levels demonstrated that the ICC group exhibited higher GP73 values than the benign liver tumor/healthy control group [standardized mean difference ( SMD)=2.53, 95% CI: 1.38-3.64], exhibited lower GP73 values than the HCC group ( SMD=-1.69, 95% CI: -2.48--0.89), and both of them reached statistically significant difference (both P<0.001). No statistically significant difference was observed between the ICC and liver cirrhosis groups ( SMD=-0.33, 95% CI: -0.92-0.26, P=0.270). Regarding tissue GP73, the ICC patients showed a significantly higher rate compared to the benign liver tumor [ RR=2.31, 95% CI: 1.83-2.93, P<0.0001], whereas no significant difference was found between the ICC and HCC groups ( RR=0.83, 95% CI: 0.57-1.22, P=0.340). GP73 for ICC diagnosis yielded an area under the ROC curve of 0.87, with a sensitivity of 73% and specificity of 75%. Conclusion:GP73 demonstrates potential utility in ICC diagnosis, but its clinical application may be confounded by concurrent conditions such as liver cirrhosis, which should be identified in clinical practice.

Objective:To systematically review the clinical value of Golgi protein 73 (GP73) in intrahepatic cholangiocarcinoma (ICC) diagnosis.Methods:Online databases were searched by researchers on CNKI, VIP, Wanfang, PubMed, Embase, and Cochrane library. Clinical studies related to the diagnosis of ICC by GP73 value were included according to inclusion and exclusion criteria. Study data were collected, and then methodological quality was evaluated. Both RevMan 5.3 software and Meta-Disc 1.4 software were used for pooled analysis to investigate the difference of GP73 value between the ICC group and non-ICC group, as well as the diagnostic efficiency of GP73 for ICC.Results:A total of 12 studies comprising 3 723 patients (2 345 males and 1 378 females, aged 18-85 years) were included in the meta-analysis. Among these, 537 cases were definitively diagnosed as ICC, while the remaining 3 186 non-ICC cases included 600 benign liver tumors or healthy controls, 1 795 hepatocellular carcinomas (HCC), and 791 cases of liver cirrhosis. Pooled analysis of serum GP73 levels demonstrated that the ICC group exhibited higher GP73 values than the benign liver tumor/healthy control group [standardized mean difference ( SMD)=2.53, 95% CI: 1.38-3.64], exhibited lower GP73 values than the HCC group ( SMD=-1.69, 95% CI: -2.48--0.89), and both of them reached statistically significant difference (both P<0.001). No statistically significant difference was observed between the ICC and liver cirrhosis groups ( SMD=-0.33, 95% CI: -0.92-0.26, P=0.270). Regarding tissue GP73, the ICC patients showed a significantly higher rate compared to the benign liver tumor [ RR=2.31, 95% CI: 1.83-2.93, P<0.0001], whereas no significant difference was found between the ICC and HCC groups ( RR=0.83, 95% CI: 0.57-1.22, P=0.340). GP73 for ICC diagnosis yielded an area under the ROC curve of 0.87, with a sensitivity of 73% and specificity of 75%. Conclusion:GP73 demonstrates potential utility in ICC diagnosis, but its clinical application may be confounded by concurrent conditions such as liver cirrhosis, which should be identified in clinical practice.

ObjectiveTo find out whether there is any difference in the monitoring results of mosq-ovitraps placed in different orientations in multi-storey residential areas, so as to provide a scientific basis for routine and emergency monitoring of Aedes albopictus with mosq-ovitraps in residential areas. MethodsFrom July 6th to October 26th 2023, one mosquito ovitrap was set up in each of the 4 orientations of east, south, west and north around the buildings in a multi-storey residential area in Jinhui Town, Fengxian District, Shanghai. Data was collected and recorded 72 hours after placement. The chi-square test was used to compare the mosquito ovitrap indices (MOIs) of two independent samples, and the Kruskal⁃Wallis H test was used to compare the MOIs of multiple independent samples. ResultsAfter 16 weeks of surveillance, 997 mosquito ovitraps were recovered, of which 211 were positive, with the mosquito ovitrap index (MOI) of 21.16% and the Aedes albopictus density index of 1.03 mosquitoes·ovitrap^-1. The MOIs were higher in September (24.22%) and October (23.96%), and the MOIs in the west, south and north within the two months were all above 20.00%. From July to October, the MOIs in the east, west, south and north were 20.70%, 22.20%, 25.50% and 16.20%, respectively, and the difference in MOIs among the 4 orientations was not statistically significant (χ²=6.647, P=0.084). Stratified analysis by month showed that in August, the south side of the multi-storey residential areas had the highest MOI (31.30%), the north side had the lowest MOI (1.30%), and there was a statistically significant difference in MOI in the east, west, south and north (χ²=25.986, P<0.001). In October, the MOI in the west was the highest (33.30%) and the MOI in the east was the lowest (6.30%), the difference in MOIs of the 4 orientations was statistically significant (χ²=12.007, P=0.007). The MOIs in the south side of the building in the outskirts of the residential area from the 1st week in July to the 4th week in October was lower (19.20%) than that in the south side of the inner building (31.70%), and the difference in MOI was statistically significant (χ²=5.118, P=0.024). ConclusionThe study of MOI in different orientations in a multi-storey residential area is a preliminary exploration based on field work, and the results show that there is a difference in MOIs in different orientations during the peak breeding period of mosquitoes. Further indicators such as temperature, humidity and wind speed in different orientations can be collected to explore the influencing factors of MOIs.

This article reports a rare case of thrombotic microangiopathy (TMA) with renal involvement complicated by allogeneic hematopoietic stem cell transplantation (allo-HSCT). The patient appeared increased serum creatinine 20 d after allo-HSCT, and gradually appeared hypertension, oliguria and edema. Despite discontinuing suspected medications, serum creatinine level did not decrease. Treatment with basiliximab and mycophenolate mofetil was initiated to prevent rejection, leading to gradual normalization of urine output and serum creatinine level. However, after stopping mycophenolate mofetil, the patient experienced recurrent increased blood pressure and decreased pulse oximetry, responding well to prednisone but recurring upon cessation, with gradually increased serum creatinine level. Renal pathology indicated that chronic TMA after allo-HSCT caused renal injury, primarily affecting the glomeruli. The renal function achieved long-term stability through low-dose prednisone and symptomatic treatment. By reviewing relevant literature, we discussed the clinical manifestations, laboratory tests, pathological features and treatment strategies of TMA with renal involvement complicated by allo-HSCT.

This paper presents a rare case of renal amyloidosis complicated with primary minimal change disease. The patient initially presented with edema and proteinuria, accompanied by IgG-λ monoclonal immunoglobulinemia, leading to a diagnosis of primary systemic immunoglobulin light chain amyloidosis with renal involvement. Following treatment, the patient achieved both hematologic and renal remission. However, a renal relapse occurred two years later, presenting as nephrotic syndrome without hematologic disease recurrence. A repeat renal biopsy revealed no obvious change in amyloid deposition, but demonstrated markedly enlarged effacement of podocyte foot processes. Based on these findings, a secondary diagnosis of primary minimal change disease was established. The patient exhibited a rapid response to immunosuppressive therapy, achieving sustained long-term remission. This case underscores the importance of remaining vigilant to etiological changes in the treatment of renal diseases and highlights the role of repeated renal biopsy in refining the diagnosis and guiding treatment.

This article reviews the diagnosis, therapeutic approaches, and subsequent care for a patient with a complex, long-standing history of encapsulating peritoneal sclerosis (EPS). A 40-year-old male, who had been on peritoneal dialysis (PD) for 11 years, encountered refractory peritonitis, leading to the removal of PD catheter and the subsequent diagnosis of EPS. The patient was transitioned to hemodialysis (HD) and prescribed tamoxifen to mitigate peritoneal fibrosis. After 4 months on HD, the patient underwent a kidney transplant, but acute rejection episode caused the transplanted kidney to fail 3 months postoperatively, necessitating a return to HD. Over the past 7 years, the patient has been repeatedly hospitalized due to recurrent bowel obstructions and infected abdominal fluid accumulation. A multidisciplinary approach, including anti-infective therapy, gastrointestinal intervention, nutritional support, and psychological care, has been instrumental in managing symptoms, and sustaining life. This case underscores the importance of recognizing EPS in long-term PD patients with peritonitis. While discontinuing PD, switching to HD, or receiving kidney transplantation do not halt the progression of EPS, optimized comprehensive management can extend the patient's survival.

This article reports a rare case of thrombotic microangiopathy (TMA) with renal involvement complicated by allogeneic hematopoietic stem cell transplantation (allo-HSCT). The patient appeared increased serum creatinine 20 d after allo-HSCT, and gradually appeared hypertension, oliguria and edema. Despite discontinuing suspected medications, serum creatinine level did not decrease. Treatment with basiliximab and mycophenolate mofetil was initiated to prevent rejection, leading to gradual normalization of urine output and serum creatinine level. However, after stopping mycophenolate mofetil, the patient experienced recurrent increased blood pressure and decreased pulse oximetry, responding well to prednisone but recurring upon cessation, with gradually increased serum creatinine level. Renal pathology indicated that chronic TMA after allo-HSCT caused renal injury, primarily affecting the glomeruli. The renal function achieved long-term stability through low-dose prednisone and symptomatic treatment. By reviewing relevant literature, we discussed the clinical manifestations, laboratory tests, pathological features and treatment strategies of TMA with renal involvement complicated by allo-HSCT.

This paper presents a rare case of renal amyloidosis complicated with primary minimal change disease. The patient initially presented with edema and proteinuria, accompanied by IgG-λ monoclonal immunoglobulinemia, leading to a diagnosis of primary systemic immunoglobulin light chain amyloidosis with renal involvement. Following treatment, the patient achieved both hematologic and renal remission. However, a renal relapse occurred two years later, presenting as nephrotic syndrome without hematologic disease recurrence. A repeat renal biopsy revealed no obvious change in amyloid deposition, but demonstrated markedly enlarged effacement of podocyte foot processes. Based on these findings, a secondary diagnosis of primary minimal change disease was established. The patient exhibited a rapid response to immunosuppressive therapy, achieving sustained long-term remission. This case underscores the importance of remaining vigilant to etiological changes in the treatment of renal diseases and highlights the role of repeated renal biopsy in refining the diagnosis and guiding treatment.

This article reviews the diagnosis, therapeutic approaches, and subsequent care for a patient with a complex, long-standing history of encapsulating peritoneal sclerosis (EPS). A 40-year-old male, who had been on peritoneal dialysis (PD) for 11 years, encountered refractory peritonitis, leading to the removal of PD catheter and the subsequent diagnosis of EPS. The patient was transitioned to hemodialysis (HD) and prescribed tamoxifen to mitigate peritoneal fibrosis. After 4 months on HD, the patient underwent a kidney transplant, but acute rejection episode caused the transplanted kidney to fail 3 months postoperatively, necessitating a return to HD. Over the past 7 years, the patient has been repeatedly hospitalized due to recurrent bowel obstructions and infected abdominal fluid accumulation. A multidisciplinary approach, including anti-infective therapy, gastrointestinal intervention, nutritional support, and psychological care, has been instrumental in managing symptoms, and sustaining life. This case underscores the importance of recognizing EPS in long-term PD patients with peritonitis. While discontinuing PD, switching to HD, or receiving kidney transplantation do not halt the progression of EPS, optimized comprehensive management can extend the patient's survival.

ObjectiveTo explore the relationship between smoking behavior and related factors among the adult residents in Fengxian District,so as to provide an evidence for carrying out tobacco control and other health promotion work. MethodsA multi-stage stratified cluster random sampling method was used to select 2 272 community residents aged between 15 and 69 yeas to carry out the questionnaire survey. ResultsIn 2020, the smoking rate of adult residents in Fengxian District was 23.50%. Smoking behavior was statistically correlated with age, gender, household registration, chronic disease, occupation and educational level. Smoking behavior was inversely correlated with educational level. Smoking rate of male residents was significantly higher than that of female residents, smoking rate of residents with chronic diseases was significantly higher than that of those without suffering from chronic diseases, and smoking rate of permanent registered residents was significantly higher than that of those non-locals. The highest smoking prevalence was among retired and freelancers, followed by staff of government agencies and public institutes, while the lowest was among students, followed by intellectuals. Multivariate logistic regression analysis showed that gender, age and education level were the main factors affecting the smoking prevalence level. ConclusionThe general　smoking rate of adult residents in Fengxian District was higher than the average level in Shanghai but lower than the national level. Male residents aged ≥25 years and with lower education level are the key invention targets for tobacco control.