Objective:To evaluate the correlation of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with the activity of pediatric Crohn′s disease (CD) , and to study the efficacy of NLR and PLR independently and combinedly in predicting active period of pediatric CD.Methods:A total of 43 children with CD (145 clinical records) admitted to Gastroenterology Department of Children′s Hospital of Nanjing Medical University from June 2017 to March 2020 were analyzed retrospectively. According to pediatric Crohn′s disease activity index, the clinical records were divided into inactive group (94 cases) , mild active group (29 cases) , moderate to severe active group (22 cases) . General information of the children and NLR and PLR results of each group on the second day after admission were collected.Results:The levels of NLR and PLR in mild active group and moderate to severe group were higher than those in inactive group [NLR: 2.96 (2.25, 4.12) vs. 1.10 (0.77, 1.92) , 3.25 (2.50, 5.53) vs. 1.10 (0.77, 1.92) ; PLR: 194.97 (143.30, 238.64) vs. 101.83 (81.75, 147.40) , 198.85 (166.95, 244.95) vs. 101.83 (81.75, 147.40) , P<0.001], but there was no significant difference between mild active group and moderate to severe active group. There were a strong positive correlation between NLR and PLR with CD activity ( rs = 0.622, P<0.001; rs = 0.582, P<0.001, respectively) . The cut-off values of NLR and PLR for predicting CD activity were 1.64 and 136.88, and the AUC was 0.877 and 0.855, respectively. The corresponding sensitivity and specificity were 96.08%, 71.28% and 84.31%, 74.47%, respectively. When NLR was combined with PLR, AUC was 0.891, sensitivity was 86.27%, and specificity was 78.72%. Conclusions:NLR and PLR can be used to distinguish the active and inactive periods of pediatric CD. The combination of NLR and PLR can be used to diagnose the active period of pediatric CD with higher AUC, sensitivity and specificity.

Objective:To evaluate the correlation of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with the activity of pediatric Crohn′s disease (CD) , and to study the efficacy of NLR and PLR independently and combinedly in predicting active period of pediatric CD.Methods:A total of 43 children with CD (145 clinical records) admitted to Gastroenterology Department of Children′s Hospital of Nanjing Medical University from June 2017 to March 2020 were analyzed retrospectively. According to pediatric Crohn′s disease activity index, the clinical records were divided into inactive group (94 cases) , mild active group (29 cases) , moderate to severe active group (22 cases) . General information of the children and NLR and PLR results of each group on the second day after admission were collected.Results:The levels of NLR and PLR in mild active group and moderate to severe group were higher than those in inactive group [NLR: 2.96 (2.25, 4.12) vs. 1.10 (0.77, 1.92) , 3.25 (2.50, 5.53) vs. 1.10 (0.77, 1.92) ; PLR: 194.97 (143.30, 238.64) vs. 101.83 (81.75, 147.40) , 198.85 (166.95, 244.95) vs. 101.83 (81.75, 147.40) , P<0.001], but there was no significant difference between mild active group and moderate to severe active group. There were a strong positive correlation between NLR and PLR with CD activity ( rs = 0.622, P<0.001; rs = 0.582, P<0.001, respectively) . The cut-off values of NLR and PLR for predicting CD activity were 1.64 and 136.88, and the AUC was 0.877 and 0.855, respectively. The corresponding sensitivity and specificity were 96.08%, 71.28% and 84.31%, 74.47%, respectively. When NLR was combined with PLR, AUC was 0.891, sensitivity was 86.27%, and specificity was 78.72%. Conclusions:NLR and PLR can be used to distinguish the active and inactive periods of pediatric CD. The combination of NLR and PLR can be used to diagnose the active period of pediatric CD with higher AUC, sensitivity and specificity.

OBJECTIVE:To observe clinical efficacy and safety of milrinone in the treatment of persistent pulmonary hyperten-sion of newborn. METHODS:52 newborns with persistent pulmonary hypertension were divided into control group and observa-tion group according to random number table,with 26 cases in each group. The control group were given mechanical ventilation and intravenous prostaglandin therapy. Observation group was treated with Milrinone injection at loading dose of 50 μg/kg,10 min intravenous injection,maintenance dose of 0.75 μg/(kg·min). Both groups received treatment for 48 h. Clinical efficacies of 2 groups were compared as well as SpO2,PaO2,OI,PAP,PAMP and SV before and after treatment. The occurrence of ADR was compared between 2 groups. RESULTS:Total effective rate of observation group was 92.31%,which was significantly higher than 80.77% of control group,with statistical significance (P<0.05). Before treatment,there was no statistical significance in SpO2,PaO2,OI,PAP,PAMP and SV levels between 2 groups(P>0.05). After treatment,above indexes of 2 groups were im-proved significantly;SpO2,PaO2,OI and SV levels of observation group were significantly higher than those of control group, while PAP and PAMP levels were significantly lower than those of control group,with statistical significance(P<0.05). No obvi-ous ADR was found in 2 groups. CONCLUSIONS:Milrinone shows significant therapeutic efficacy in the treatment of persistent pulmonary hypertension of newborn,and can significantly improve persistent pulmonary hypertension and increased oxygen con-tent of blood with good safety.