1.Physicochemical Characterization and Biocompatibility of Bioactive Glass/Polycaprolactone Scaffold for Alveolar Bone Regeneration
Ain Nurfatehah Arupudin ; Ahmad Hazim Norafizal ; Farha Ariffin ; Siti Noor Fazliah Mohd Noor ; Nurul Aida Ngah
Archives of Orofacial Sciences 2025;20(2):111-124
Physicochemical Characterization and Biocompatibility of Bioactive Glass/Polycaprolactone Scaffold for Alveolar Bone Regeneration
In bone tissue engineering, scaffold-based approaches offer great potential for regenerating damaged
or lost bone tissue. Composite scaffolds have gained popularity because they combine the beneficial
properties of two or more materials, providing promising biomimetic properties for tissue regeneration.
In our study, combining the biocompatibility of bioactive glass with the mechanical qualities of
polycaprolactone provides tailored properties and scaffold architecture conducive to alveolar bone
regeneration. This study aims to develop a bone substitute using bioactive glass/polycaprolactone
(BG/PCL) composites and to evaluate its biocompatibility for potential applications in alveolar bone
regeneration. BG/PCL scaffolds were fabricated using a solvent-casting method at three different weight percentages (wt.%) ratios (10:90, 20:80, and 30:70). The scaffolds were characterised using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and methyl tetrazolium (MTT) (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) Assay to evaluate their physical, chemical, and biocompatibility properties. Among the three BG:PCL composite ratios tested (10:90, 20:80, and 30:70), the 10:90 ratio demonstrated the most favourable properties. SEM analysis of this composition revealed optimal surface roughness and well-distributed interconnected pores, which are conducive to cell attachment, enhanced cellular infiltration, and efficient nutrient diffusion. FTIR spectra displayed characteristic absorption bands corresponding to the functional groups of BG and PCL components while the biocompatibility test confirmed the viability and proliferation of periodontal ligament (PDL) fibroblast cells when cultured with the scaffolds. This study demonstrates that the developed BG/PCL composite, especially at the 10:90 ratio, possesses suitable properties and biocompatibility, highlighting its potential for use in alveolar bone regeneration.
2.Managing Recurrent Traumatic Gingival Ulceration Secondary to Aberrant Frenal Attachment with Modified Kazanjian Vestibuloplasty: A Case Report
Nur Zety Mohd Noh ; Nurul Qamar Salehuddin ; Farha Ariffin
Annals of Dentistry 2024;31(No.1):31-35
Managing Recurrent Traumatic Gingival Ulceration Secondary to Aberrant Frenal Attachment with Modified Kazanjian Vestibuloplasty: A Case Report
The current study described tooth 45 buccal high frenum attachment of a 56-year-old male patient associated with shallow vestibule adjacent to the edentulous ridge of missing tooth 46 management. The patient reported recurring traumatic ulcers on teeth 44 and 45 buccal gingiva due to frequent toothbrush slippage. The patient also requested an implant for missing tooth 46. A modified Kazanjian vestibuloplasty was performed before replacing the missing tooth. Subsequently, the patient was reviewed at one and two weeks, one month, and monthly for up to six months. The patient did not report traumatic ulcer development within the surgery site and improved plaque control. Consequently, performing mucogingival surgery in cases of inadequate keratinised tissue width, decreased vestibular depth, and high muscle pull is recommended. The procedure facilitates plaque control, reduces or halts gingival recession, and enhances comfort during tooth brushing.
3.Poly-Ether-Ether-Ketone (PEEK) Removable Partial Dentures: A Scoping Review
Nor Faharina Abdul Hamid ; Rohana Ahmad ; Rohana Ahmad ; Farha Ariffin ; Solehudin Shuib
Archives of Orofacial Sciences 2024;19(2):57-78
Poly-Ether-Ether-Ketone (PEEK) Removable Partial Dentures: A Scoping Review
This scoping review aims to comprehensively assess the existing evidence from both clinical and in
vitro studies concerning removable partial dentures (RPD) made from poly-ether-ether-ketone (PEEK)
to identify current research gaps and enhance the understanding of PEEK’s viability as a material
for RPD. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
extension for scoping reviews was applied. A search was made using PubMed, Web of Science,
Elsevier’s Scopus, ProQuest and Springer Link databases for articles in the English language up
to November 2023, focusing on case reports, clinical, and in vitro studies. A total of 33 studies were
included in the analysis, which consisted of 4 case reports, 6 clinical studies, and 23 in vitro studies.
Clinical studies predominantly examined patient satisfaction post-PEEK RPD insertion, framework
accuracy, dimensional changes in residual ridges, and fungal/bacterial adhesion to PEEK. In vitro studies emphasized retentive force clasps (12 studies), accuracy and fitness (5 studies), material staining effects (3 studies), and diverse surface treatments (3 studies). The current body of evidence reveals a scarcity of clinical studies investigating PEEK as an RPD framework. In vitro studies primarily focused on assessing material retentive forces, with limited attention given to accuracy, surface treatment, and staining of denture base materials. Future research should address these gaps, exploring aspects such as adhesion and biofilm formation (e.g. Candida albicans) on RPD surfaces. Rigorous, well-designed clinical trials and expanded in vitro investigations are essential to establish PEEK RPD as definitive prostheses for partially edentulous patients.
4.Bibliometric Analysis of Removable Partial Denture-related Research in Dentistry
Nor Faharina Abdul Hamid ; Farha Ariffin ; Rohana Ahmad
Archives of Orofacial Sciences 2023;18(no.2):103-124
The objective of this study was to characterise articles published in removable partial denture (RPD)
research from 1948 to 2022 to identify the most influential journals, publications, authors, and core
research areas using bibliometric analysis. The Scopus database was used to retrieve publications with titles containing the truncated search term (“removable partial denture*” OR “removable prostho*”). Data analysis and visualisation were done using Microsoft Excel, Biblioshiny software and VOSviewer. A total of 2,484 articles were analyses from 1948 till 2022, representing an annual growth rate of 4.9%. The Journal of Prosthodontic Research demonstrated the highest average normal citation rate, with productive authors with highest citations being from Japan. From 1948 to 1999, most in-vitro and clinical research focused on the basic concept of RPD using cobalt-chromium as a framework before shifting to titanium in 2000. RPD research after 2012 focuses on new technology and non-metalbased frameworks as an alternative to metal-based frameworks. Wakabayashi and Fueki were the most prominent researchers, according to a three-field plot analysis, with the Journal of Prosthetic Dentistry, Journal of Oral Rehabilitation, and Journal of Prosthodontic Research among the authors’ preferred journals. “CAD/CAM” and “3D printing” were identified as emerging themes in year 2020 to 2022, while “selective laser melting” was the trending keyword in 2017 to 2019. Research on “oral health and quality of life” has been identified as core research area in RPD-related research. RPD research on digital dentistry and new framework materials is anticipated to increase in the future with the incorporation of research on quality of life.
5.Inflammation of the Gums
Intan Suhana Munira Mat Azmi ; Farha Ariffin ; Hassan Basri Mukhali
Malaysian Family Physician 2020;15(1):71-73
An 18-year-old woman presented to the clinic with painless bleeding of her gums upon brushing her
teeth. The bleeding stopped spontaneously, and there was no other bleeding tendency. On further
questioning, the patient had irregular menses and was taking the oral contraceptive pills (OCP)
Diane-35ED® to regulate her menses. She had been on this medication for four months. She was not
on any other medication and had no chronic illness.


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