Objective To explore the theory of the drug property and resource characteristics contained in the classic clinical work of traditional Chinese medicine Treatise on the Spleen and Stomach,providing references for the clinical use of medicines.Methods Chinese herbal medicines recorded in the prescriptions of Treatise on the Spleen and Stomach were collected and to establish a corresponding database.The theory of drug property recorded was analyzed,and resource characteristics were analyzed by methods of modern Chinese medicinal resource science.Results A total of 63 prescriptions of Treatise on the Spleen and Stomach were collected,involving 105 Chinese medicines.High frequency Chinese medicine include 16 kinds of drugs such as Gancao,Renshen and Chenpi et al.The warm-natured Chinese medicine were the most common used,accounting for 46.67％,the spicy Chinese medicine accountting for 39.74％,mainly belong to the spleen meridian,accounting for 53.53％,toxic Chinese medicine were used less.Conclusion More than 94％of Chinese medicine contained Treatise on the Spleen and Stomach are still in clinical use,and the application of reinforcing drugs,relieving drugs and Qi-regulating drugs is of great significance to clinical guidance.

Objective To explore the theory of the drug property and resource characteristics contained in the classic clinical work of traditional Chinese medicine Treatise on the Spleen and Stomach,providing references for the clinical use of medicines.Methods Chinese herbal medicines recorded in the prescriptions of Treatise on the Spleen and Stomach were collected and to establish a corresponding database.The theory of drug property recorded was analyzed,and resource characteristics were analyzed by methods of modern Chinese medicinal resource science.Results A total of 63 prescriptions of Treatise on the Spleen and Stomach were collected,involving 105 Chinese medicines.High frequency Chinese medicine include 16 kinds of drugs such as Gancao,Renshen and Chenpi et al.The warm-natured Chinese medicine were the most common used,accounting for 46.67％,the spicy Chinese medicine accountting for 39.74％,mainly belong to the spleen meridian,accounting for 53.53％,toxic Chinese medicine were used less.Conclusion More than 94％of Chinese medicine contained Treatise on the Spleen and Stomach are still in clinical use,and the application of reinforcing drugs,relieving drugs and Qi-regulating drugs is of great significance to clinical guidance.

Objective To explore the core theories and medication characteristics of traditional Chinese medicine in the treatment of Sj?gren syndrome(SS).Methods Search for relevant literatures on the treatment of SS with traditional Chinese medicine published in CNKI,Wanfang Data Knowledge Service Platform,VIP,and SinoMed from the establishment of the database to September 30,2022,screen the prescriptions for the treatment of SS with traditional Chinese medicine and conduct data mining.Results A total of 137 prescriptions were finally selected,involving 186 Chinese medicines.Among them,yin-nourishing medicines,interior heat-clearing medicines and qi-tonifying medicines were used most frequently,and Maidong,Shengdihuang,Baishao ranked among the top 3 in terms of usage frequency.The four qi of Chinese medicines were mainly based on the cold,and the five flavors were based on the sweet flavors.The channel tropism were based on lung meridian and liver meridian.Entropy clustering analysis finally obtained four new prescriptions.Conclusion The treatment of SS is based on nourishing yin for moistening dryness,invigorating spleen and replenishing qi,removing toxicity substance and resolving macula,and dredging channels.At the same time,it emphasizes the application of concepts such as sour and sweet transform into yin,body fluids and blood share the same source,and seeking yin from yang.

Objective To explore the core theories and medication characteristics of traditional Chinese medicine in the treatment of Sj?gren syndrome(SS).Methods Search for relevant literatures on the treatment of SS with traditional Chinese medicine published in CNKI,Wanfang Data Knowledge Service Platform,VIP,and SinoMed from the establishment of the database to September 30,2022,screen the prescriptions for the treatment of SS with traditional Chinese medicine and conduct data mining.Results A total of 137 prescriptions were finally selected,involving 186 Chinese medicines.Among them,yin-nourishing medicines,interior heat-clearing medicines and qi-tonifying medicines were used most frequently,and Maidong,Shengdihuang,Baishao ranked among the top 3 in terms of usage frequency.The four qi of Chinese medicines were mainly based on the cold,and the five flavors were based on the sweet flavors.The channel tropism were based on lung meridian and liver meridian.Entropy clustering analysis finally obtained four new prescriptions.Conclusion The treatment of SS is based on nourishing yin for moistening dryness,invigorating spleen and replenishing qi,removing toxicity substance and resolving macula,and dredging channels.At the same time,it emphasizes the application of concepts such as sour and sweet transform into yin,body fluids and blood share the same source,and seeking yin from yang.

Objective The present study was to investigate the feasibility of use of high resolution magnetic reso?nance vessel wall imaging(HR-VWI)in evaluation of intracranial aneurysms. Methods We prospectively collected data from patients who had intracranial aneurysms and received HR-VWI scan before surgical treatment or conservative treatment. Aneurysms were divided into ruptured group (n=12) and unruptured group (n=88). Aneurysm site, size, neck, aspect ratio(AR), daughter sac and aneurysmal wall enhancement scale were analyzed in both groups. Univariate and multivariate Logistic regression were performed to evaluate the risk factors of aneurysm rupture. Subgroup analysis was also performed to study symptomatic and asymptomatic unruptured aneurysms. Results Aneurysm size(t=2.187,P=0.031),AR(t=3.164,P=0.002),incidence of daughter sac(P=0.012) and aneurysmal wall enhancement scale(P<0.001)were higher in ruptured aneurysm group. Multivariate Logistic regression showed that aneurysmal wall enhance?ment scale was the only independent risk factor of ruptured aneurysms(P=0.002). Subgroup analysis showed aneurysm wall enhancement scale(P<0.001) and AR(t=3.939,P<0.001) were higher in symptomatic unruptured aneurysms. Conclusion Aneurysm wall enhancement on HR-VWI is more frequently seen in ruptured aneurysms and symptomatic unruptured aneurysms. Histological study is needed for better understanding of the mechanism of aneurysm wall enhance?ment.

Objective To analyze the clinical features of pediatric sepsis with initial symptoms of autoimmune hemolytic anemia(AIHA) and acute renal failure.Methods Ten cases of pediatric sepsis with initial symptoms of AIHA and acute renal failure were selected from January 2000 to January 2014 in Department of Nephrology,Beijing Children's Hospital Affiliated to Capital University of Medical Science.The clinical data were retrospectively analyzed and long-time follow-up was taken.Results There were 8 boys and 2 girls of the 10 cases.The ages ranged from 8 months to 12.8 years.There were 8 children less than 6 years old having a prevalence of 80％.There were sudden dark urine and progressive anemia in all the cases,jaundice in 9 cases,abdominal pain and vomiting in 6 cases.Urine volume decreased in 7 cases and anuria in 3 cases.Four cases showed disorder of consciousness and 2 developed shock.Respiratory failure and disseminated intravascular coagulation happened in 1 case respectively.In terms of pathogens,2 cases were infected by mycoplasma and 1 case was infected by hemolytic streptococcus.The rest of the pathogen was unknown.The Coomb's test was 3 +-4 + positive.Serum urea nitrogen and creatinine gradually increased.High level total serum bilirubin and unconjugated bilirubin were shown in 8 cases and low level complement in 7 cases.Bone marrow films showed hyperplasia in all the cases.Renal biopsy was taken in 3 cases and no microthrombus was found.Corticosteroid was used in all 10 cases for 6 months.Blood purification was taken in 8 cases.Respiratory support was used in 4 cases.Nine recovered and 1 case gave up treatment.Further follow-up was taken for 2.2-8.1 years.Eight cases had normal urine and blood routine test and renal function.Relapse happened in 1 girl 1 year later.One case lost follow-up.Conclusions Once sudden hemoglobinuria,anemia and progressively decreased urine output occur in sepsis cases,the clinicians should consider AIHA and acute renal failure.Based on active infection control,the early use of steroids and blood purification treatment can improve the prognosis.

Objective To explore the application effect of comprehensive nursing in the postoperative nursing of patients with urinary calculi. Methods Totally 56 patients treated with ureteroscopy lithotomy in Tengzhou Central Peopl′s Hospital during December 2015 to May 2016 wererandomly selected and divided into the control group ( 26) and the intervention group ( 30) . Comprehensive nursing interventions were carried out in the intervention group, while the control group adopted routine postoperative nursing care. Pain scores one day, two days and three days after intervention and the scores of self-rating anxiety scaleone day, three days and five days after intervention were assessed and compared between two groups. Results The SAS score of patients at different time(in 1-day, 3-days and 5-days after operation)was significantly different (F=11.383,P<0.05);there were significant difference in the SAS score between two groups (F=4.981,P<0.05); and there was interaction between the assessment before and after and the interventions(F=8.402,P<0.05). There was no significant difference in the pain score of patients one day and two days after operation (P>0.05). The pain score of patients in the observation group three days after operation was lower than that in the control group ( P<0.05).Conclusions Comprehensive nursing can obviously relieve patient′s postoperative pain and anxiety.

In this paper,non-funded projects peer review feedbacks of Tianjin University of Traditional Chinese Medicine 2013 National Science Foundation of China was analyzed,feedbacks by passed and non-passed peer meeting review of the Department of Medical Science were classified separately,from the aspects of research program research content,innovation,the preliminary work and others aspects were statistically analyzed,finally contrary to results put forward a number of methods to improve the scientific management

Objective To assess the indications,effect and complications of plasma exchange(PE) application in children.Methods A total of 93 patients treated with PE were enrolled,and the clinical mani-festations before and after treatment were analyzed retrospectively.Results Ninety-three cases of children received PE treatment 2 to 1 1 times,an average of 5.5 times,53 cases with combination blood purification treatment.In 93 patients,there were 36 cases with hemolytic uremic syndrome,among them,22 cases (61.1 %)were healed,14 cases(38.9%)remained hematuria,and proteinuria and 5 of them(13.9%)with injured renal function.There were 9 cases with Guillain-Barre'syndrome and 8 of them got improved.Six in 8 cases with anti-N-methyl-D-aspartate receptorencephalitis got better after treatment.All of the 3 cases with myasthenia gravis got recovery.There were 4 cases with acute disseminated encephalomyelitis and 4 cases with chronic inflammatory demyelinating polyneuropathy respectively.The treatment effect rate was all 3 /4. Four in 9 patients with poisonous mushroom poisoning also got improved.The adverse reactions were ob-served in 12 cases(12.9%),including allergic in 9 cases and hypotension in 3 patients.No serious adverse reactions were found during treatment.Conclusion PE is an safe and effective blood purification method, with less adverse reaction,for treatment of the atypical hemolytic uremic syndrome and some serious nervous system diseases,such as myasthenia gravis,Guillain-Barre syndrome,etc.

Objective To analyze the clinical characteristics,prognosis and the risk factors in 48 children with lupus nephritis combined with renal insufficiency.Methods The clinical data from 48 pediatric lupus nephritis with renal insufficiency from January 2000 to January 2013 were retrospectively analyzed.Results Forty-eight cases showed renal insufficiency among 168 children with lupus nephritis,and the incidence rate was 28.6％.The age ranged from 5.8 to 16.2 years.The male to female ratio was 1.0 ∶ 2.2.Among 48 children,43 cases had hematuria,41 cases had heavy proteinuria,25 cases had anaemia and 23 cases had persistent hypertension.Totally 20 cases underwent renal biopsy,and among them,15 cases(75.0％) were diagnosed as diffuse proliferative lupus nephritis(class Ⅳ).The histological activity index was ≥7 in 13 cases and the histological chronicity index was ≥4 in 3 cases.Corticosteroid and/or cytotoxic drugs were used in all of 48 cases.Thirty-five cases had normal urine and renal function,5 cases had stable renal function with persistent proteinuria,4 cases developed into chronic renal failure and 4 cases died.Persistent hypertension (x2 =4.274,P =0.039),the time of starting therapy (x2 =28.830,P =0.000),and histologic chronicity index(P =0.008 8 by Fisher's exact probability test)were the prognostic factors.Conclusions Among pediatric lupus nephritis with renal insufficiency,class Ⅳ (diffuse proliferative lupus nephritis) is the most frequent finding.Persistent hypertension,the time of starting therapy,and histologic chronicity index are the prognostic factors.The outcomes of lupus nephritis with insufficiency can be improved by adequate and appropriate treatment.