Objective : To investigate the high-risk human papillomavirus ( HR-HPV) infection and its relationship with vaginal infectious diseases among women and to provide a basis for the prevention and control of cervical canc- er among women in this region． Methods: Uterine exfoliative cells and vaginal secretions were collected from women aged 25－64 years in the resident population ( ≥6 months of residence) who participated in cervical cancer screening and human papillomavirus typing and vaginal microecology tests were performed to compare the status of HPV infections in different age groups．The study subjects were divided into HR-HPV-positive and HR-HPV-nega- tive groups according to whether HR-HPV infection was detected or not，and multifactorial Logistic regression anal- ysis was used to explore the relationship between HR-HPV and vaginal infectious diseases． Results : The HR-HPV infection rate of women in this study was 10. 43% ，and the HR-HPV infection rate of each age group was 14. 34% from 25 to 34 years old，10. 16% from 35 to 44 years old，8. 70% from 45 to 54 years old，and 11. 89% from 55 to 64 years old，and there were differences in the infection rate of HR-HPV among different age groups ( P < 0. 05) ．Among HR-HPV，HPV52，HPV16，HPV58，HPV51，HPV68 were the most common，with 76. 69% of sin- gle infections，18. 02% of dual infections，4. 46% of triple infections，and 0. 83% of quadruple infections．HR- HPV single infections and multiple infections were prevalent in the age group of 25－34 years old and 55－64 years old．HR-HPV mono-infection and multi-infection rates were statistically different between age groups ( P＜0. 05) ． The infection rates of bacterial vaginosis ( BV) and trichomoniasis vaginitis ( TV) were higher in HR-HPV-positive patients ( P ＜0. 05) ． Logistic regression analysis showed that the infection rates of BV ( OR = 1. 560，95% CI: 1. 195－2. 035 ) ，TV ( OR = 2. 208，95% CI: 1. 221 －3. 993 ) were risk factors for HR-HPV infection ( P < 0. 05) ． Conclusion In the screened population of the Fourth Division of Xinjiang Production and Construction Corps，HR-HPV mono-infection is the most prevalent type．Women aged 25－34 and 55－64 years old show higher rates of HR-HPV infection．The most common HR-HPV genotypes，in descending order，are 52，16，58，51，and 68．BV and TV are the two major risk factors closely associated with HR-HPV infection．

Objective:To investigate the control situation of drinking water-type endemic fluorosis (hereinafter referred to as drinking water fluorosis) in Xinjiang Production and Construction Corps (hereinafter referred to as the Corps), identify weak links in prevention and control, and provide reference for precise prevention and control of drinking water fluorosis in the Corps.Methods:Monitoring data of drinking water fluorosis areas in the Corps from January to December 2022 were collected from the Corps Center for Disease Control and Prevention, the level of fluoride in drinking water and the prevalence of dental fluorosis in children aged 8 - 12 were analyzed retrospectively.Results:In 2022, the qualified rate of water fluoride in the disease affected TuanChang of the Corps was 100.00% (62/62), and the qualified rate of water fluoride in the disease affected company was 99.44% (705/709). The prevalence of dental fluorosis in children aged 8 - 12 in the disease affected TuanChang was 3.38% (1 412/41 714), and there was no statistically significant difference in the prevalence of dental fluorosis among different age groups (χ 2 = 6.07, P = 0.194). The prevalence of dental fluorosis in children aged 8 - 12 in the TuanChang where the company with water fluoride exceeding standard was located (6.00%, 106/1 768) was higher than that in the TuanChang where the company with qualified water fluoride was located (3.27%, 1 306/39 946, χ 2 = 38.47, P < 0.001). Conclusion:In 2022, the drinking water fluorosis in the Corps has reached the control standard, but attention still should be paid to the water improvement situation and maintenance of water improvement projects in some water fluoride exceeding standard companies, in order to prevent sustained dental fluorosis damage to children in the affected areas, and consolidate the achievements of prevention and control.

Abstract: Objective　To investigate the treatment outcomes of patients with pulmonary tuberculosis (PTB) in Xinjiang Production and Construction Corps and to explore the risk factors affecting these outcomes, so as to provide a scientific basis for the prevention and treatment of pulmonary tuberculosis in the corps region. Methods　TB patients registered in the Corps from 2016 to 2022 were selected, and the basic demographic and clinical data of the research objects were collected by retrospective method. Log-rank test was used for univariate analysis and the Cox multivariate regression model was used to analyze the influencing factors of treatment outcomes of patients with pulmonary tuberculosis. Results　From 2016 to 2022, a total of 8 838 TB patients were registered in the TB Management Information System of Xinjiang Production and Construction Corps, of which 495 cases were untreated, 43 cases had changed diagnoses, 301 cases had no treatment outcomes, 6 cases were diagnosed as extrapulmonary tuberculosis, 11 cases were diagnosed as tracheobronchial tuberculosis, and finally 7 982 TB patients were included in the study. Of the 7 982 patients, 7 578 (94.94%) were treated successfully, while 404 (5.06%) had adverse outcomes (including 32 cases of failure, 13 cases of TB death, 173 cases of non-TB death, 12 cases lost to follow-up, 94 cases of adverse reactions, 10 cases transferred to multi-drug resistance treatment, and 70 other cases). Multivariate Cox regression analysis showed that the >30 to 60-year-old and >60-year-old age groups (OR=1.565, P=0.009; OR=2.960, P<0.001), belonging to ethnic minorities (OR=1.526, P<0.001), being a patients with diabetes mellitus (OR=1.696, P=0.002), current address being in other areas of the province or patients from other provinces (OR=1.419, P=0.004; OR=1.624, P=0.001), receiving retreatment (OR=1.910, P<0.001), and absence of primary care management (OR=1.351, P=0.003) were the risk factors for unsuccessful treatment outcomes in the corps' pulmonary tuberculosis patients. Conclusions　The treatment success rate of pulmonary tuberculosis patients in the Corps region is relatively high, but there is still a need to strengthen the treatment and management of the elderly, ethnic minorities, diabetes patients, non-local floating population, retreatment patients and patients who did not receive primary management.

Objective:To understand the iodine content of edible salt in residents of Xinjiang Production and Construction Corps (referred to as Corps), and provide scientific evidence for prevention and treatment of iodine deficiency disorders.Methods:According to the requirements of the "National Iodine Deficiency Disorders Surveillance Program" form 2015 to 2019, in accordance with the principle of random sampling, one regiment from each of the five directions of east, west, south, north and center in the Corps was selected, and four companies were selected from each regiment. Edible salt samples from the homes of 15 residents in each company were collected, and salt iodine content was quantitatively tested and the test results were analyzed.Results:From 2015 to 2019, 21 028 household salt samples were collected, qualified iodized salt were 20 204, non-qualified iodized salt were 712, non-iodized salt were 112, iodized salt coverage rate was 99.47% (20 916/21 028), iodized salt qualified rate was 96.60% (20 204/20 916), qualified iodized salt consumption rate was 96.08% (20 204/21 028). The average salt iodine content was (27.72 ± 4.81) mg/kg. From 2015 to 2019, the iodized salt coverage rates in the whole Corps were all > 95%, and the iodized salt qualified rates and the qualified iodized salt consumption rate were all > 90%. Among the 14 divisions of the Corps, iodized salt coverage rates were all > 95%, except for the 12th and 14th divisions, where the iodized salt qualified rates and qualified iodized salt consumption rates were < 90%, all other divisions were > 90%.Conclusions:Iodized salt coverage rate, iodized salt qualified rate and qualified iodized salt consumption rate have all reached the national standard for eliminating iodine deficiency disorders from 2015 to 2019, however, non-iodized salt exists in some areas, and the qualified iodized salt consumption rate is low. We should strengthen monitoring of iodized salt in key areas and promote health education, consolidate and maintain achievements in eliminating iodine deficiency disorders.

Objective To analyze the impact of reduction of iodine content in iodine salt on iodine nutrition level among children and pregnant women in Xinjiang Production and Construction Corps (hereinafter referred to as the Corps).Methods In 2011 (before adjusting),the population proportional probability sampling (PPS) method was used to select 30 round fields in the Corps,one primary school was selected in each round field,and 40 children aged 8-10 years old (half males and half females) were taken from each primary school,to collect salt samples from their homes,salt iodine level was determined and thyroid examination was performed;among those 40 children,12 children (half males and half females) were selected,and urine samples were collected to test urine iodine level;at the same time,10 pregnant women were selected from the school location,and their urine samples were collected to test urine iodine level.In 2015 (after adjusting),in 14 divisions of the Corps,one round field was selected in each division from each of five directions of east,west,south,north and middle.Four company teams were selected in each round field,and 15 salt samples of households were collected in each company team,salt iodine was detected.One team primary school was selected in each round field,40 children aged 8-10 years old (half males and half females) were taken from each primary school,urine samples were collected to detect urine iodine level,and thyroid examination was performed;20 pregnant women were taken from each round field,and urine samples were collected to detect urine iodine level.A comparative analysis of iodine nutritional status in children and pregnant women in 2011 and 2015 was conducted.Goiter was examined by B-ultrasonography;salt iodine was detected by direct titration;urine iodine was detected by arsenic cerium catalytic spectrophotometry (WS/T 107-2006).Results A total of 1 195 and 4 215 salt samples were collected in 2011 and 2015,the medians of salt iodine were 32.3 and 28.2 mg/kg,respectively;the goiter rates of children were 3.4％ (42/1 220) and 1.0％ (26/2 552),respectively,both were below national standards (5.0％);the medians of urine iodine of children were 235.3 and 217.9 μg/L,respectively,both were more than the appropriate level;the medians of urine iodine of pregnant women were 183.0 and 157.7 μg/L,respectively,both were at appropriate level.Conclusion The reduction of salt iodization has no significant effect on iodine nutritional status in children and pregnant women,the iodine nutrition levels of children and pregnant women are good.

Objective To analyze epidemiological characteristics of brucellosis in Xinjiang Production and Construction Corps and to provide evidences for control and prevention of the disease.Methods Retrospective study method was used to collect the epidemic characteristics of cases and serological surveillance of brucellosis data in Xinjiang Production and Construction Corps from 2013 to 2017,the time,region,population distribution characteristics and laboratory test results of the disease were analyzed.Results In 2013-2017,the Xinjiang Production and Construction Corps reported a total of 3 287 cases of brucellosis,with an average annual incidence of 24.02/100 000,and no death case was reported.During the period,the incidence was 21.11/100 000,29.73/100 000,26.68/100 000,20.10/100 000 and 19.23/100 000,which showed a decline trend in general (linear x2 =23.67,P ＜ 0.01).The largest cumulative numbers of reported cases of the Corps were in five divisions,they were the Eighth Division with 599 cases,the Sixth Division with 470 cases,the Fourth Division with 366 cases,the Tenth Division with 320 cases and the Ninth Division with 313 cases,and they accounted for 62.91％ (2 068/3 287) of the total number of cases in the whole Corps.Brucellosis occurred in each month of the year,the number of cases reported from March to August accounted for 72.59％ (2 386/3 287),the peak incidence occurred in May and June,showing obvious seasonal fluctuation.Of all reported cases,74.78％ (2 458/3 287) were men,and 25.22％ (829/3 287) were women,38.97％ (1 281/3 287) were at the ages of 40-49 years,farmer was the highest occupation which accounted for 47.52％ (1 562/3 287).Totally 24 120 blood samples were collected from high-risk occupation during the period and 457 samples were positive for Brucella antibody,with an average positive rate of 1.89％,of the positive cases,52.30％ (239/457) had symptoms of brucellosis.Conclusions On the whole,the epidemic of brucellosis in Xinjiang Production and Construction Corps is declining year by year.But as the epidemic slowly expands,all departments should strengthen joint prevention and control measures,control and eliminate the source of infection.At the same time,we should strengthen the propaganda,education and behavior intervention for high-risk occupational groups.

Objective To understand the current situation of iodine deficiency disorders of Xinjiang Production and Construction Corps,in order to provide evidence for establishing prevention and control strategies.Methods According to their sub-area positions of east,west,south,north and center,5 units were extracted in each division via the random sampling method,4 companies were sampled in each chosen unit,15 households were selected in each chosen company to detect salt iodine content in 2015;and 1 elementary school was sampled in each chosen unit,40 students aged 8-10 were selected to collect their urine samples in each school to test urinary iodine and determine the goiter.Twenty pregnant women were randomly selected in each unit to test urinary iodine.Salt iodine was tested using direct titration,urinary iodine was determined using arsenic osmium catalytic spectrophotometry,thyroid was examinated using B-ultrasound.Results Totally 3 915 edible salt samples were monitored.The mean of salt iodine was (27.8 ± 5.5) mg/kg,with 99.1％ (3 880/3 915) iodized salt coverage rate,93.2％ (3 617/3 880) iodized salt qualified rate and 92.4％ (3 617/3 915) qualified iodized salt consumption rate.The goiter rate was 1.0％ (26/2 552) and the median of urinary iodine was 217.9 μg/L of 2 552 children aged 8-10,urinary iodine of southern region and northern region was 212.1 and 222.1 μg/L,respectively.The median of urinary iodine of 1 233 pregnant women was 157.7 μg/L.Conclusion The iodine nutrition level of key groups have already reached the national standard for eliminating iodine deficiency disorders,we should pay more attention to lower level urinary iodine of pregnant women.

Objective: To analyze the phylogenetic characteristics of enterovirus 71 (EV71) in Xinjiang Production and Construction Corps from 2011 to 2016, providing pathogenic information for prevention and control of hand-foot-mouth disease (HFMD). Methods: The EV71 positive strains were conducted for reverse transcription polymerase chain reactions (RT-PCR) amplification on entire VP1 coding region and sequencing was then performed and finally phylogcnetic tree was constructed among these strains and representative strains from GenBank using MEGA6.06. Results: The homology of nucleotide and amino acid of the 37 EV71 strains were 87.3%-100.0% and 93.1%-100.0%, and belonged to EV71 C4a subgenotype, of 7 relatively independent small branches. Of the epidemic strains, compared with the representative strains, mutation occurred on 28 amino acid sites, the variation (Serine to Threonine, Alanine to Serine) happened on the 283 and 293 amino acid site in 9 strains. Conclusions The 37 EV71 strains in Xinjiang Production and Construction Corps from 2011 to 2016 belonged to EV71 C4a subgenotype, mutation occurred on 28 amino acid sites, and there is a common variation on the 283 and 293 amino acid site in 9 strains.

Objective To assess the status of knowledge,attitude and behaviors on brucellosis among key population of Xinjiang Production and Construction Corps,so as to provide a basis for specially carrying out health education and behavioral intervention.Methods According to the geographical distribution in Xinjiang,using the method of multistage stratified sampling to select farm households,herdsman,veterinary,and meat processing personnel over 9 years old from eight divisions (South Xinjiang:1,2 division and Northern Xinjiang 6,7,8,9,10 division) and so on as the research object from March 2013 to December 2015.Adopt self-designed questionnaire to carry out a face to face and household investigation.Results Totally 11 098 brucellosis key persons of eight divisions were investigated,and the total awareness rate was 83.61％ (92 794/110 980),with the First Division (75.78％,10 769/14 210) and the Sixth Division (66.45％,10 154/15 280) lower than the total awareness rate (x2 =52.8,288.1,all P＜ 0.01).The knowledge of brucellosis increased with the education level of the participants (x2 linear =6 245.3,P ＜ 0.01).There were significant differences in the knowledge of brucellosis among different nationalities (x2 =6 912.8,P＜ 0.01),and the Uygur (56.73％,3 909/6 890) and Hui (57.93％,2 850/4 920) were obviously lower than that in the Han (87.27％,78 932/90450).The awareness of different age groups was different (x2 =407.1,P ＜ 0.01),the ＞ 60 age group (74.63％,3 515/4 710) was the lowest.Different occupations were also different (x2 =675.5,P ＜ 0.01),and the farm households (81227％,4 4228/54 420) were lower,the veterinary was the highest (94.86％,2 438/2 570).Conclusions The brucellosis awareness rate of Xinjiang Corps region has reached the level of the epidemic areas,but ethnic minorities,the elderly and occupational population are still relatively low.We should take further measures to strengthen health education so as to improve the protection consciousness of local residents.

Objective To evaluate the effectiveness of control and prevention of iodine deficiency disorders(IDD) in Xinjiang Production and Construction Corps. Methods According to the national requirement and the situation of Xinjiang Production and Construction Corps, thirty sampling units were selected by the“probability proportionate to size” method; one school was chosen in each sampling unit; forty children (half male half female) aged 8 - 10 years old were chosen in each school. Family salt samples were collected to detect salt iodine content, and the goiter was determined. Twelve children(half male half female) from the 40 children were selected; urine samples were collected to detect urinary iodine content. Twenty fifth-grade children in each school and five housewives around each school were selected, and the survey of health education knowledge was conducted. Salt iodine was measured using direct titration (GB/T 13025.7-1999);the volume of thyroid was detected by ultrasound ( WS 276-2007 ); urinary iodine was measured by arsenic Ce catalytic spectrophotometry method (WS/T 107-2006). Results A total of 1 195 household salt samples were tested. The mean of salt iodine was (30.91 ± 6.99)mg/kg;the coverage rate of iodized salt was 97.49%(1 165/ 1 195);the qualified rate of iodized salt was 98.54%(1 148/1 165); and the consumption rate of qualified iodized salt was 96.07%(1 148/1 195). Twelve hundred and twenty children aged 8-10 years old were examined;forty-two goiters were examined;and goiter rate was 3.44%. Four hundred and seven urine samples were tested, the median of urinary iodine was 235.31 μg/L;< 50 μg/L accounted for 1.47%(6/407); and 50 - < 100 μg/L accounted for 6.63%(27/407). The awareness rates of IDD health education knowledge of the fifth-grade students and housewives were 84.39%(1 519/1 800) and 84.44%(380/450), respectively. Conclusion The level of IDD control and prevention in Xinjiang Production and Construction Corps has been up to the national standard of eliminating IDD.