Carbonic anhydrase IX (CAIX) is a transmembrane protein that is specifically overexpressed on the surface of hypoxic tumor cells. With the function of regulating the acidity of tumor cells both inside and outside, CAIX is closely related to tumor proliferation, invasion and metastasis. Therefore, CAIX is a promising target for tumor imaging and therapy. Herein, we summarized recent advances in CAIX-based tumor imaging, therapy and theranostics, and prospected future applications of using CAIX as an anti-tumor target.
Carbonic Anhydrase IX ; Carbonic Anhydrases/metabolism* ; Cell Line, Tumor

Objective:This study aims to understand the anxiety and depressive symptoms among the front-line medical staff against the COVID-19 and the related factors.Methods:130 front-line medical staff from Tianyou Hospital Affiliated to Wuhan University of science and technology were assessed by the Generalized Anxiety Disorder Scale (GAD-7), the Patient Health Questionnaires (PHQ-9) scale, and the simple self-designed questionnaire (including 8 factors related to anxiety and depressive symptoms). The prevalence of anxiety and depression of different participants according to demographic characteristics were compared with χ 2 test. The association between depression/anxiety and impact factors was analyzed using the Pearson correlation method. Results:48 people had anxiety and depressive symptoms, accounting for 36.9%（48/130） of the total sample. 41 people had anxiety symptoms, accounting for 31.8% (41/130) of the total sample. 36 people had depressive symptoms, accounting for 27.7% (36/130) of the total sample. Gender, age, marital status, education level, occupation, professional title, department, and duration of taking part in the fight against the COVID-19 had no correlation with the prevalence of anxiety. Gender, age, marital status, occupation, professional title, department, and duration of taking part in the fight against the COVID-19 had no correlation with the prevalence of depression, however education level had correlation with the prevalence of depression (χ2=5.220， P=0.034). Disease factor, work factor, time factor, and safety factor were all related to anxiety and depression. The proportion of management factors in the anxiety group was significantly higher than that in the group without anxiety (χ2=13.578， P<0.01). The proportion of other factors in the group without anxiety was significantly higher than that in the group with anxiety(χ2=6.229， P=0.012). The severity of anxiety and depression was positively correlated with disease factor, work factor, time factor, safety factor, and management factor, and negatively correlated with other factors ( r=-0.287， P<0.05). Conclusion:There were anxiety and depressive symptoms in front-line medical staff against COVID-19, which was significantly related to the characteristics of the COVID-19 epidemic. It is necessary to carry out psychological intervention for this population.

Objective:This study aims to understand the anxiety and depressive symptoms among the front-line medical staff against the COVID-19 and the related factors.Methods:130 front-line medical staff from Tianyou Hospital Affiliated to Wuhan University of science and technology were assessed by the Generalized Anxiety Disorder Scale (GAD-7), the Patient Health Questionnaires (PHQ-9) scale, and the simple self-designed questionnaire (including 8 factors related to anxiety and depressive symptoms). The prevalence of anxiety and depression of different participants according to demographic characteristics were compared with χ 2 test. The association between depression/anxiety and impact factors was analyzed using the Pearson correlation method. Results:48 people had anxiety and depressive symptoms, accounting for 36.9%（48/130） of the total sample. 41 people had anxiety symptoms, accounting for 31.8% (41/130) of the total sample. 36 people had depressive symptoms, accounting for 27.7% (36/130) of the total sample. Gender, age, marital status, education level, occupation, professional title, department, and duration of taking part in the fight against the COVID-19 had no correlation with the prevalence of anxiety. Gender, age, marital status, occupation, professional title, department, and duration of taking part in the fight against the COVID-19 had no correlation with the prevalence of depression, however education level had correlation with the prevalence of depression (χ2=5.220， P=0.034). Disease factor, work factor, time factor, and safety factor were all related to anxiety and depression. The proportion of management factors in the anxiety group was significantly higher than that in the group without anxiety (χ2=13.578， P<0.01). The proportion of other factors in the group without anxiety was significantly higher than that in the group with anxiety(χ2=6.229， P=0.012). The severity of anxiety and depression was positively correlated with disease factor, work factor, time factor, safety factor, and management factor, and negatively correlated with other factors ( r=-0.287， P<0.05). Conclusion:There were anxiety and depressive symptoms in front-line medical staff against COVID-19, which was significantly related to the characteristics of the COVID-19 epidemic. It is necessary to carry out psychological intervention for this population.

Tetrahydroisoquinoline alkaloids distributed widely in the nature and some have a broad application in clinic. More attention has been paid in recent years on this type of alkaloid, owing to the diverse range of biological activities exhibited by these alkaloids and the discovery of new functional mechanisms and molecular targets underlying these activities. This article summarized the recent advances in the biological activities and functional mechanism of tetrahydroisoquinoline, which included the activities such as antitumor, antibiotic, antivirus, anti-inflammatory, anticoagulation, bronchodilation, and the action on central nervous system, with the purpose of providing some ideas in the study of biological activity of this type of alkaloid and in the search for lead-compound and rational drug design.

Objective To investigate the effects of aerobic exercises on the pulmonary ventilation function and electrocardiac activity of simple obesity primary school students. Methods 30 simple obesity boy students were recruited for this study. All the subjects participated in a 12-week aerobic training program (40 min/day,4 days/week). Body composition,pulmonary function and electrocardiogram were tested at the beginning and the end of the training program. Results Decreases of fat mass and body fat ratios were found in response to the exercise stimulus (P<0.05). Free-fat mass(FFM) significantly increased. No statistically significant differences of waist hip ratio (WHR) were found. Among the pulmonary ventilation function indexes,MVV、FEV_1、V_(50)/Ht and PEFR increased significantly (P<0.05, P<0.01). Among the EEG indexes,QTd value and QTcd value decreased significantly (P<0.05,P<0.01). Conclusion Aerobic exercises could improve the pulmonary ventilation function of simple obesity primary school students,and had favorable regulations on electrocardiac activity.

Tetrahydroisoquinoline alkaloids distributed widely in the nature and some have a broad application in clinic. More attention has been paid in recent years on this type of alkaloid, owing to the diverse range of biological activities exhibited by these alkaloids and the discovery of new functional mechanisms and molecular targets underlying these activities. This article summarized the recent advances in the biological activities and functional mechanism of tetrahydroisoquinoline, which included the activities such as antitumor, antibiotic, antivirus, anti-inflammatory, anticoagulation, bronchodilation, and the action on central nervous system, with the purpose of providing some ideas in the study of biological activity of this type of alkaloid and in the search for lead-compound and rational drug design.