OBJECTIVE To optimize the drying methods of Compound Scutellaria baicalensis extract powder. METHODS Compound S. baicalensis extract powder was prepared by atmospheric pressure drying， decompression drying and spray drying respectively， and high-performance liquid chromatography （HPLC） fingerprint of the extract powder was established. The physical fingerprint of the extract powder was established by 13 secondary indexes， such as particle size， particle size distribution and bulk density. HPLC fingerprints and physical fingerprints of 3 kinds of extract powders were compared by similarity evaluation method； through the conversion of the secondary indexes， five primary indexes of homogeneity， stacking， compressibility， fluidity and stability were calculated， and the physical properties of 3 kinds of extract powder were evaluated. The compressibility parameters of 3 kinds of extract powder such as index of parameter （IP）， index of parametric profile （IPP） and index of good compression （IGC） were calculated by the secondary index to evaluate the compression formability of the powder. RESULTS The similarity means of HPLC fingerprint of the extract powder obtained by atmospheric pressure drying， decompression drying and spray drying were 0.74， 0.90 and 0.94， respectively， and the similarity means of physical fingerprint were 0.74， 0.83 and 0.92， respectively. The overall similarity of spray drying extract powder was higher. The results of physical fingerprint analysis showed that the physical properties of the extract powder obtained by different drying methods were different. The 3 kinds of extract powder showed poor stability but good stacking. The homogenity and compressibility of extract powder by spray drying and decompression drying were better than those by atmospheric pressure drying， but the fluidity was worse than that by atmospheric pressure drying. The results of further compression formability analysis showed that the IP of spray drying extract powder was 0.54， IPP was 5.23， IGG was 5.03， and the spray drying extract powder could be directly pressed after adding a small amount of lubricant. CONCLUSIONS There are differences in HPLC and physical fingerprints of Compound S. baicalensis extract powder obtained by different drying methods. The spray drying extract powder possesses better Δ 基金项目 四川省公益性科研院所基本科研项目 （No.2022- 4-720） overall quality， which is more suitable for the drying of ＊第一作者副主任药师。研究方向：临床药学、药事管理、药物研 Compound S. baicalensis extract powder. 究。E-mail：hyptotti@163.com

OBJECTIVETo investigate the efficacy and safety of nebulizing glucocorticoid combined with olfactory training in the treatment of postviral olfactory dysfunction.METHODSPatients with postviral olfactory dysfunction were recruited in this study. All patients underwent T&T olfactory testing, sinonasal computer tomgraphy scanning, as well as magnetic resonance scanning of the olfactory pathway. Nebulizing glucocorticoid (pulmicort repulse) was inhaled once daily at the starting dose of 2 mg tapered to 1 mg after two weeks combined with olfactory training for 4 weeks. T&T olfactory testing were repeated after 4-week treatment.RESULTS Twenty four patients received teatment, with a mean age of 54 years old(range 37 to 81 years old), a mean olfactory dysfunction course of 2.20 months(range, 0.25-9 months). Of whom, 21 were anosmia, 3 were hyposmia. After teatment, complete recovery were achieved in 4 patients(16.7%), obvious improvement in 9 (37.5%), improvement in 5 (20.8%), no improvement in 6 (25.0%). No side effect and untoward effect were found.CONCLUSIONThe primmary outcomes suggest the efficacy and safety of nebulizing glucocorticoid combined with olfactory training in the treatment of postviral olfactory dysfunction.

Glucocorticoids ; therapeutic use ; Humans ; Olfaction Disorders ; drug therapy ; Smell

Objective To study the feasibility and rehabilitation outcomes of one -stage cochlear implantation (CI) in profound deaf children with secretory otitis media (SOM ) .Methods A total of 11 profound deaf children with soal receired one -soage unilateral cochlear implantation with a follow -up period from 13~60 months .In-flamed mucosa in the mastoid as well as exudates were removed radical1y at the time of implantation for adequate drainage of the middle ear .After the sugery ,the patients were followed up and the hearing and rehabilitating out-comes were eveluated .Results All 11 patients were successfully operated with 8 cases in the right ear and 3 cases in the left ear .Among them ,7 cases were nucleus 24 CA ,1 case losa clarion AB 90 K ,2 cases were medel combi 40+and 1 case was pulsar .All patients were successfully operated .No infectious complications occurred .No recurrence of secretory otitis media was observed .After initial stimulation and post regular fitting ,the status of the implant-able devices were all stable .All the implantees had satisfied hearing and entered normal kindergartens or schools . Conclusion Profound deaf pediatric patients with SOM are not an absolute contraindication for CI .With sufticient pre-operation preparontion ,proper trentment and nursing .Cochlear implantation should be condnote as early as possible better rehabilitation performance .

OBJECTIVE: To evaluate the etiology and management of delayed epistaxis after endoscopic surgery. METHOD: To retrospectively analyze the clinical data of 11 cases for epistaxis after nasal endoscopic surgery. To compare their precipitating factors, their surgical approach, time and site of bleeding and management in order to find the intrinsic rules. RESULT: The precipitating factors, bleeding sites and treatments varied among patients. CONCLUSION Delayed epistaxis after endoscopic surgery can not be neglected. There may be some precipitating factors. The surgical approach may be related to the bleeding site. It is better to treat the epistaxis using the endoscope to explore the bleeding site and to give corresponding intervention.
Adult ; Endoscopy ; adverse effects ; Epistaxis ; etiology ; therapy ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications ; etiology ; therapy ; Retrospective Studies ; Young Adult

OBJECTIVE: To describe a modified lateral pharyngoplasty with partial transsection of levator veli palatine muscle in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and report the primary outcomes. METHOD: Retrospective review was performed in sixty patients with OSAHS. All the patients underwent modified surgical procedures, including partial transsection of levator veli palatine muscle and high soft palatoplasty. RESULT: The patients with a reduction of the AHI at least 50% were 6 (6/60, 10%). The patients with a reduction of the AHI at least 50% and a postoperative AHI < 20 were 44 (44/60, 73.3%). The patients with a postoperative AHI < 5 were 10 (10/60, 16.7%). Postoperative complications were postoperative bleeding in two cases (3.3%) and short-term velopharyngeal insufficiency in 10 cases (16.7%). CONCLUSION Lateral pharyngoplasty with partial transsection of levator veli palatine muscle provides a safe and effective procedure for selected OSAHS patients with oropharyngeal collapse as the main site.
Adult ; Apnea ; surgery ; Female ; Humans ; Male ; Middle Aged ; Oral Surgical Procedures ; methods ; Palate, Soft ; surgery ; Pharynx ; surgery ; Retrospective Studies ; Sleep Apnea, Obstructive ; surgery ; Treatment Outcome

Objective To study the effect of thermo-radiotherapy on multidrug resistance (MDR) and levels of intracellular adriamycin (ADM) in tongue squamous cell carcinoma cell line Tca 8113 and its MDR cell line Tca 8113/CBDEA. Methods Samples of the two cell lines were treated with thermo-radiotherapy (42℃ for 0.5 h and 2 Gy of radiation). Four and 24 hours later, the expression of the MDR relative proteins P-glycoprotein (P-gp),multidrug resistance associate protein 1 (MRP1) and glutathione s-tranferase-π (GST-π) were detected using immu-nohistochemistry. Intracellular ADM concentrations were measured using an HTS 7000 Plus bioassay reader. Re-sults No change in the expression of P-gp was observed in the Tca 8113/CBDEA and Tca 8113 cell lines after 4 or 24 hours. Expression of MRP1 was not significantly altered in the Tca 8113/CBDEA cell line, but there was a signifi-cant drop in the Tca 8113 cell line 24 hours post-thermo-radiotherapy. Expression of GST-π was not altered in either the Tca 8113/CBDEA or the Tca 8113 cell line at 4 hours post-thermo-radiotherapy, but there was a significant de-crease at 24 hours. At both 4 and 24 hours, drug tolerance had decreased and intracellular drug concentration had in-creased significantly in both cell lines. Conclusions Thermo-radiotherapy can enhance the effects of chemotherapy and suppress the expression of MDR factors induced by radiation. The combination of hyperthermia and radiotherapy does not induce MDR.

OBJECTIVE: To explore the feasibility, option of surgical method and surgery opportunity of local flap reconstruction in nasal defects due to severe infection after rhinoplasty. METHOD: The clinical datum of eleven patients, who had 15 cases of local flap reconstruction due to severe infection after rhinoplasty, were analyzed retrospectively. The lesions included defects of nasal dorsum, nasal tip and anterior-nare-vestibular fistula. Areas of defects ranged from 1.5 cm x 1.2 cm to 2.0 cm x 2.5 cm and fistula diameters fell between 0.6 cm and 0.9 cm. Based on the principal of nasal aesthetic sub-unit, nasal defects were restored with local flaps, such as nasal dorsum flaps, rhomboid flaps and nasal columella-tip flaps. The early changes and the maintenances of nasal contour after reconstruction were observed. RESULT: All 15 reconstructions were carried out 2 weeks after control of infection, and stage-I recovery was achieved in all the cases. In the follow-up periods from 4 to 27 months, all the flaps survived. only 2 cases had distortion of nasal tips, however, they were recovered with subcutaneous injection restoration; the other cases received satisfactory nasal contour where the flaps matched well with the neighbor skin in color, texture and extent of actinic dermatitis. CONCLUSION Based on the principal of nasal aesthetic sub-unit, the individualized early local flap reconstruction would have good effect on nasal function and aesthetics, which will restore self-confidence of the patients as soon as possible.
Adult ; Female ; Humans ; Infection ; complications ; Male ; Postoperative Complications ; surgery ; Reconstructive Surgical Procedures ; methods ; Rhinoplasty ; adverse effects ; Skin Transplantation ; Surgical Flaps ; Young Adult

OBJECTIVE To explore the feasibility, surgical method, surgical effect and postoperative complications of stage-I functional reconstruction of traumatic deviated nose deformityaccompanied with chronic rhino-sinusitis.METHODS 37 patients with traumatic deviated nose deformity accompanied with chronic rhino-sinusitis were selected in this study.Methods of stage-I reconstruction included endoscopic nasal septoplasty, functional endoscopic sinsus surgery(FESS), turbinectomy, rhinoplasty and so on.The patients were followed up for one month after operation.The shape of the nose was observed and the nasal bias was measured also.At 3 months after operation, the therapeutic effect about the chronic nasosinusitis was estimated by endoscopic check and patients' subjective symptom.The data obtained preoperatively and postoperatively were treated with statistical methods.RESULTS 37 patients with traumatic deviated nose deformity were selected in this study.The postoperative bias was 2.04 ?0.97 mm and preoperative bias was(6.64?2.21) mm.A t-test revealed the significant difference between pre-and postoperative bias(t=6.374, P

The relapse after orthognathic surgery was frequently reported in recent years. But up to now researches concerning bio-mechanic mechanism of relapse are rare. The purpose of this study, by imitating the operation on monkeys, was to examine the biomechanical properties and histological characteristics after operation in order to investigate the mechanism of the relapse after orthognathic surgery. 20 rhesus monkeys divided into two groups were subjected to bilateral sagittal split and oblique osteotomy, respectively. The broken strength, stress and strain of the operated sites were examined with the use of biomechanical methods, and the healing scab was observed using histological method and SEM at 3, 6, 12, 24 weeks after operation. The results obtained demonstrated that bone healing and biomechanical properties reached certain level after 6 to 12 weeks' recovery in both operation groups; the biomechanical properties and histological characteristics recovered faster in sagittal split group than in oblique osteotomy group. Histological examination also demonstrated similar results. From the data above it is suggested that the higher relapse rate in sagittal split may more closely related to the mechanical effect different from the scab healing, although 8 weeks' fixation may meet the requirement of clinical treatment, accessory fixation method should be adopted after the removal of inter-maxilla fixation.
Animals ; Biomechanical Phenomena ; Bone Regeneration ; Female ; Fracture Healing ; Macaca mulatta ; Male ; Mandible ; pathology ; surgery ; Osteotomy ; methods ; Recurrence