Vascular aging refers to the progressive decline in functional and structural integrity of blood vessels under physiological and pathological conditions, serving as the pathophysiological basis for systemic organ aging and age-related vascular diseases.With the acceleration of global population aging, vascular aging has emerged as a critical determinant of cardiovascular health.Its mechanisms involve cascade interactions among endothelial dysfunction, phenotypic switching of vascular smooth muscle cells, and extracellular matrix remodeling, with chronic inflammation and oxidative stress playing pivotal roles.Clinically, noninvasive quantification of vascular function and structure has been achieved through pulse wave velocity, flow-mediated dilation, and imaging modalities(ultrasound, CT/MRI), yet challenges persist regarding insufficient specificity of biomarkers and standardization of multimodal assessments.Among intervention strategies, conventional pharmacological agents(e.g., ACE inhibitors, statins) and lifestyle modifications(caloric restriction, exercise) delay vascular aging via multi-target regulatory mechanisms, while emerging therapies such as senolytics and stem cell-based therapies demonstrate promising therapeutic potential.Future research should prioritize the integration of interdisciplinary approaches to advance the clinical translation of the Chinese expert consensus on clinical assessment and intervention of vascular aging(2024 edition).

Vascular aging (VA) is a common etiology of various chronic diseases and represents a major public health concern. Intermittent hypoxia (IH) associated with obstructive sleep apnea-hypopnea syndrome (OSAHS) is a primary pathological and physiological driver of OSAHS-induced systemic complications. A substantial proportion of OSAHS patients, estimated to be between 40% and 80%, have comorbidities such as hypertension, heart failure, coronary artery disease, pulmonary hypertension, atrial fibrillation, aneurysm, and stroke, all of which are closely associated with VA. This review examines the molecular and cellular features common to both OSAHS and VA, highlighting decreased melatonin secretion, impaired autophagy, increased apoptosis, increased inflammation and pyroptosis, increased oxidative stress, accelerated telomere shortening, accelerated stem cell depletion, metabolic disorders, imbalanced protein homeostasis, epigenetic alterations, and dysregulated neurohormonal signaling. The accumulation and combination of these features may underlie the pathophysiological link between OSAHS and VA, but the exact mechanisms by which OSAHS affects VA may require further investigation. Taken together, these findings suggest that OSAHS may serve as a novel risk factor for VA and related vascular disorders, and that targeting these features may offer therapeutic potential to mitigate the vascular risks associated with OSAHS.
Humans ; Sleep Apnea, Obstructive/pathology* ; Aging/physiology* ; Oxidative Stress/physiology* ; Animals

With the deepening of the aging population, China's healthcare resources and social security systems are facing increasingly significant challenges.Concurrently, the field of geriatric medicine is experiencing vigorous development, with the Chinese Medical Association playing a pivotal role in the discipline construction of geriatrics.This article will systematically outline the current development landscape, core achievements, existing challenges, and future directions of geriatric medicine in China.

With the continuous deepening of population aging in China, the development of geriatric medicine discipline holds significant strategic importance in achieving the transformation toward a "health-centered" medical model.Focusing on the practical challenges in the development of geriatric medicine, this article proposes the "Eight Major Centers" initiative as a key mechanism to construct a new service system in the field.These centers cover vascular aging management, health management, emergency and critical care, nutrition support, comprehensive assessment, organ rehabilitation, perioperative management, and perioperative management and care services for the elderly, aiming to shift from single-disease treatment toward comprehensive health management.Furthermore, the article also puts forward the pathways to promote the high-quality development of the discipline, providing references for building a geriatric medicine discipline system with Chinese characteristics.

With the deepening of the aging population, China's healthcare resources and social security systems are facing increasingly significant challenges.Concurrently, the field of geriatric medicine is experiencing vigorous development, with the Chinese Medical Association playing a pivotal role in the discipline construction of geriatrics.This article will systematically outline the current development landscape, core achievements, existing challenges, and future directions of geriatric medicine in China.

With the continuous deepening of population aging in China, the development of geriatric medicine discipline holds significant strategic importance in achieving the transformation toward a "health-centered" medical model.Focusing on the practical challenges in the development of geriatric medicine, this article proposes the "Eight Major Centers" initiative as a key mechanism to construct a new service system in the field.These centers cover vascular aging management, health management, emergency and critical care, nutrition support, comprehensive assessment, organ rehabilitation, perioperative management, and perioperative management and care services for the elderly, aiming to shift from single-disease treatment toward comprehensive health management.Furthermore, the article also puts forward the pathways to promote the high-quality development of the discipline, providing references for building a geriatric medicine discipline system with Chinese characteristics.

Vascular aging refers to the progressive decline in functional and structural integrity of blood vessels under physiological and pathological conditions, serving as the pathophysiological basis for systemic organ aging and age-related vascular diseases.With the acceleration of global population aging, vascular aging has emerged as a critical determinant of cardiovascular health.Its mechanisms involve cascade interactions among endothelial dysfunction, phenotypic switching of vascular smooth muscle cells, and extracellular matrix remodeling, with chronic inflammation and oxidative stress playing pivotal roles.Clinically, noninvasive quantification of vascular function and structure has been achieved through pulse wave velocity, flow-mediated dilation, and imaging modalities(ultrasound, CT/MRI), yet challenges persist regarding insufficient specificity of biomarkers and standardization of multimodal assessments.Among intervention strategies, conventional pharmacological agents(e.g., ACE inhibitors, statins) and lifestyle modifications(caloric restriction, exercise) delay vascular aging via multi-target regulatory mechanisms, while emerging therapies such as senolytics and stem cell-based therapies demonstrate promising therapeutic potential.Future research should prioritize the integration of interdisciplinary approaches to advance the clinical translation of the Chinese expert consensus on clinical assessment and intervention of vascular aging(2024 edition).

Integration of sports and medicine focuses on using exercise to prevent chronic diseases and enhance physical health.Frailty, a common syndrome in the elderly, has significant impacts on various aspects of their well-being.China currently lacks clear and unified recommendations for physical and health integration interventions for frailty.This consensus aims to gather the latest evidence and clinical experiences, both domestically and internationally, to minimize functional impairments in the elderly, slow down frailty progression, and improve quality of life through integrated strategies.Ultimately, the goal is to ensure the health and well-being of the elderly population.

Objective:To investigate the role of 24-dehydrocholesterol reductase(DHCR24)in doxorubicin-induced senescence-related dysfunction of vascular endothelial cells.Methods:Human umbilical vein endothelial cells(HUVECs)were induced with 0.05 μM doxorubicin for 48 h to establish a stress-triggered premature senescence model.The lentiviral transfection method was employed to achieve DHCR24 overexpression in HUVECs.Cell senescence was evaluated by β-galactosidase staining and Western blot to detect the expression of the senescence-related molecules cyclin-dependent kinase inhibitor 1A(P21)and nicotinamide adenine dinucleotide dependent histone deacetylase 1(SIRT1).Western blot was performed to detect DHCR24 and endothelial nitric oxide synthase(eNOS)expression during endothelial senescence.DAF-FM DA(an NO fluorescent probe)was used to detect intracellular NO production.Results:In the stress-triggered premature senescence model of HUVECs induced by doxorubicin, the expression of the senescence marker P21 was up-regulated( t=19.44, P<0.01), SIRT1 was down-regulated( t=10.10, P<0.01, and the expression of DHCR24 was down-regulated( t=5.946, P<0.01), compared with the control group.Meanwhile, eNOS and NO expression was inhibited( t=11.26, P<0.01; t=10.83, P<0.01).After DHCR24 overexpression, compared with the control stimulation group, the overexpression stimulation group showed that DHCR24( F=72.10, P<0.01)was up-regulated.DHCR24 overexpression alleviated the doxorubicin-induced decrease in eNOS and NO( F=5.797, P<0.05; F=45.12, P<0.01), compared with the control group. Conclusions:DHCR24 may mitigate doxorubicin-induced senescence-related vascular endothelial dysfunction by modulating the eNOS/NO signaling pathway.

Integration of sports and medicine focuses on using exercise to prevent chronic diseases and enhance physical health.Frailty, a common syndrome in the elderly, has significant impacts on various aspects of their well-being.China currently lacks clear and unified recommendations for physical and health integration interventions for frailty.This consensus aims to gather the latest evidence and clinical experiences, both domestically and internationally, to minimize functional impairments in the elderly, slow down frailty progression, and improve quality of life through integrated strategies.Ultimately, the goal is to ensure the health and well-being of the elderly population.