Systemic lupus erythematosus （SLE） may lead to secondary gynecological and obstetric disorders such as decreased ovarian reserve function， menstrual abnormalities， and adverse pregnancy outcomes. Based on "bi （痹） of both body and viscera" theory， this paper proposed that the core mechanism of SLE secondary gynecological and obstetric diseases lies in the mutual transformation between "body bi" and "viscera bi"， which together affect the uterus. Physiologically， uterus forms an internal-external network with the body and viscera through the meridians and blood vessels. Pathologically， when the healthy qi is deficient， nourishment of the body and viscera is impaired； when toxins and stasis accumulate， pathogenic factors disturb the uterus through the chong （冲） and ren （任） meri-dians. The resulting obstruction in the uterus can， in turn， manifest externally and aggravate damage to the body and viscera. Therefore， the pathogenesis of SLE secondary gynecological and obstetric diseases follows a dynamic trajectory of "body bi first， body bi affecting viscera， and then bi of both body and viscera". In treatment， the principle of harmonizing and balancing the healthy qi is emphasized. The main approach is to regulate the viscera， stabilize the body， and nourish the uterus， with the coordination of nourishing the viscera through the body， thereby achieving simultaneous treatment of both body and viscera. This highlights the guiding significance of the "bi of both body and viscera" theory in preventing and treating SLE secondary gynecological and obstetric diseases.

OBJECTIVE： To study analgesic and anti-inflammatory effects of sophocarpine （SC） on inflammatory pain model mice and related COX-2/PGE2 signaling pathway. METHODS： （1）Analgesic experiment. Totally 50 mice were randomly divided into blank control group （normal saline）， positive control group （aspirin， 100 mg/kg） and SC high-dose， medium-dose and low-dose groups （40， 20， 10 mg/kg）， with 10 mice in each group. They were given relevant medicine once a day intragastrically for consecutive 5 d. 2 h after last medication， mice in each group was given glacial acetic acid solution intraperitoneal injection； writhing times of mice within 15 minutes were recorded. Other 50 mice were collected； they were grouped and given medicine as above. The response pain threshold （Tr） of mice was determined by intelligent hot plate instrument 15， 30， 60， 120 min after last administration. （2）Anti-inflammatory and mechanism experiment. Other 60 mice were randomly divided into blank control group （normal saline）， model control group （normal saline）， positive control group （aspirin， 100 mg/kg）， SC high-dose， medium-dose and low-dose groups （40， 20， 10 mg/kg）， with 10 mice in each group； they were given relevant medicine intragastrically， once a day， for consecutive 5 d. 60 min after last medication， except for blank control group， other groups were given 1％ carrageenan to induce inflammation. 1， 3， 5 h after inducing inflammation， the degree of paw swelling were determined in each group. Other 30 mice were randomly divided into blank control group （normal saline）， model control group （normal saline）， SC group （40 mg/kg）， with 10 mice in each group； they were given relevant medicine intragastrically once a day， for consecutive 5 d. 60 min after last medication， except for blank control group， other groups were given 1％ carrageenan to induce inflammation in other groups. 5 h later， the levels of SOD， MDA， GSH-Px and T-AOC in paw swelling tissue of mice were determined by biochemical method. The level of PGE2 in paw swelling tissue was determined by ELISA. The mRNA and protein expressions of COX-1 and COX-2 in paw swelling tissue of mice were detected by RT-PCR and Western blot method. RESULTS： In analgesic experiment， compared with blank control group， writhing times of mice were decreased significantly in administration groups （P＜0.05 or P＜0.01）， Tr were increased significantly 30， 60， 120 min after last medication （P＜0.05 or P＜0.01）. In anti-inflammatory and mechanism experiment， compared with blank control group， the degree of paw swelling were increased significantly in model control group 1， 3， 5 h after inducing inflammation （P＜0.01）； the levels of SOD， GSH-Px and T-AOC in paw swelling tissue were decreased significantly （P＜0.01）； the levels of MDA and PGE2 were increased significantly （P＜0.01）， and mRNA and protein expressions of COX-2 were increased significantly （P＜0.01）. Compared with model control group， the degree of paw swelling were decreased significantly in positive control group， SC high-dose and low-dose groups 3 and 5 h after inducing inflammation （P＜0.05 or P＜0.01）. The levels of SOD， GSH-Px and T-AOC in paw swelling tissue were increased significantly in SC group （P＜0.05 or P＜0.01）， while the levels of MDA and PGE2 were decreased significantly （P＜0.01） as well as mRNA and protein expressions of COX-2 were decreased significantly （P＜0.05）. There was no statistical significance in other indexes （P＞0.05）. CONCLUSIONS： SC possesses good anti-inflammatory and analgesic effects， and its mechanism may be related to anti-oxidative stress and inhibition of COX-2/PGE2 signaling pathway.

Objective To evaluate the intervention effect of Yi?Han bilingual health education of schistosomiasis control. Methods Baimiao Village in Daqing Town,Xichang City,where Yi Nationality inhabited,was chosen as a pilot to carry out Yi?Han bilingual health education of schistosomiasis control from 2012 to 2015. The villagers and students in the pilot area were in?vestigated by questionnaires before and after the intervention to understand their awareness and correct behavior status on schis?tosomiasis control. Results After the intervention of Yi?Han bilingual health education of schistosomiasis control for 3 years, the awareness rate and the correct rate of behavior on schistosomiasis control of the villagers in the pilot area improved from 45.79%and 51.12%in 2012 to 97.80%and 98.78%in 2015. As for the students,the two rates mentioned above improved from 64.16%and 60.83%in 2012 to 100%and 98.89%in 2015 respectively,and all the differences between the rates before and af?ter the intervention were statistically significant( all P<0.01). Conclusion The intervention of Yi?Han bilingual health educa?tion of schistosomiasis control can obviously improve the knowledge awareness rates and the correct rates of behavior of the resi?dents and students in the gathering area of Yi Nationality.

Objective To understand the impact of Qionghai Lake wetland ecological protection construction on the preva?lence of schistosomiasis,so as to provide the evidence for formulating the strategies for schistosomiasis control and prevention. Methods A retrospective survey of the construction of Qionghai Lake wetland was performed,and eleven villages around the wetland were surveyed for schistosomiasis endemic situation. The influence of the wetland project on the schistosomiasis preva?lence and Oncomelania hupensis snail status were investigated. Results Before the construction of Qionghai Lake wetland,the snail elimination and extended chemotherapy for residents was performed. After the project was finished,the roads and ditches were hardened. From 2009 to 2014,the schistosome infection rate of residents declined from 0.37% to 0. No schistosome infect?ed snails were found and in recent 2 years,no snails were found. No mice were infected in the sentinel tests. Conclusions The construction of Qionghai Lake wetland effectively eliminates snails,and interrupts the transmission of schistosomiasis. Howev?er,the environment of the wetland is more suitable for snail breeding,and therefore,the surveillance still should be strength?ened.