Objective To systematically evaluate the effects of prone position ventilation on newborn with respiratory distress syndrome.Methods We searched databases including PubMed,EMBASE,Cochrane Library,Web of Science,CBM,CNKI,Wanfang and VIP.We included all randomized controlled trials and randomized crossover trials of neonatal respiratory distress syndrome.Studies were selected according to inclusion and exclusion criteria,extracting data and assessing quality.Then RevMan 5.3 software was used to analyze the data.Results Ten studies included seven randomized controlled trials and three randomized crossover trials,and 500 patients were included.The results of meta-analysis showed that in prone position ventilation group SaO2[MD=2.41,95％CI(0.87,3.95),P=0.002],PaO2[MD=5.20,95％CI(3.04,7.36),P＜0.001],Pa2//FiO2[MD=24.40,95％CI(8.35,40.44),P=0.003],the risk of pneumothorax [RR =0.10,95％ CI (0.01,0.76),P=0.03] and intracranial hemorrhage [RR =0.41,95％ CI (0.20,0.83),P=0.01]and duration of mechanical ventilation [MD=-23.22,95％CI(-38.30,-8.14),P=0.003] compared with supine positiongroup had significantly statistical difference;however there was no significant difference in ventilator-associated pneumonia[RR=0.72,95％CI(0.48,1.09),P=0.12] between two groups.Conclusion Prone position ventilation is effective to improve SaO2,PaO2 and PaO2/FiO2,shorten duration of mechanical ventilation and reduce the risk of pneumothorax and intracranial hemorrhage in newborn with respiratory distress syndrome.While it could not effectively reduce incidence of ventilator-associated pneumonia.Due to the limitations of the quality of studies included,multi-centered randomized controlled trials with large sample size are needed in the future to evaluate the effects of prone position ventilation on neonatal respiratory distress syndrome.

Objective To investigate changes of bone metabolism in rats with premature ovary failure (POF) and the effects of hyperbaric oxygenation (HBO) on bone metabolism.Methods Forty SPF Wistar rats were randomly divided into 4 groups:the blank control group,the model control group,the hormone replacement therapy (HRT) group and the HBO group,each consisiting of 10 animals.Except the blank control group,all the other groups were orally given triptegium wilfordii polyglycisidium (TWP) solution to establish premature ovary failure model.And then,rats in the HRT group were given orally estrogen and progestin.Rats in the HBO group were treated with HBO and the same dosage of normal saline.Rats in the control group and the model control group were given orally the same dosage of normal saline.Then,changes of serum bone alkaline phosphatase (BALP) and tartrate-resistant acid phospatase (TRACP) in different groups were observed accordingly.Results When compared with that of the blank control group,the level of BALP in the model control group[(245.24 ± 25.21) ng/L] was decreased significantly (P ＜ 0.01),while the level of TRACP[(3453.69 ± 413.82) pg/L] was increased markedly (P ＜ 0.01).BALP levels of the HRT group [(342.16 ± 18.68) ng/L] and the HBO group [(306.64 ± 22.96) ng/L] were all higher than those of the model control group,while TRACP levels[(1735.48 ± 94.56) and (1889.63 ± 70.81) pg/L] were all lower than those of the model control group [(3453.69 ± 413.82)pg/L],with statistical significance (P ＜ 0.01).Conclusions HBO could affect bone metabolism in rats with premature ovary failure,had enhancing effect on BALP in bone formation,and at the same time had certain suppressing effect on TRACP in its role of bone absorption.

Objective To investigate changes of bone metabolism in rats with premature ovary failure (POF) and the effects of hyperbaric oxygenation (HBO) on bone metabolism.Methods Forty SPF Wistar rats were randomly divided into 4 groups:the blank control group,the model control group,the hormone replacement therapy (HRT) group and the HBO group,each consisiting of 10 animals.Except the blank control group,all the other groups were orally given triptegium wilfordii polyglycisidium (TWP) solution to establish premature ovary failure model.And then,rats in the HRT group were given orally estrogen and progestin.Rats in the HBO group were treated with HBO and the same dosage of normal saline.Rats in the control group and the model control group were given orally the same dosage of normal saline.Then,changes of serum bone alkaline phosphatase (BALP) and tartrate-resistant acid phospatase (TRACP) in different groups were observed accordingly.Results When compared with that of the blank control group,the level of BALP in the model control group[(245.24 ± 25.21) ng/L] was decreased significantly (P ＜ 0.01),while the level of TRACP[(3453.69 ± 413.82) pg/L] was increased markedly (P ＜ 0.01).BALP levels of the HRT group [(342.16 ± 18.68) ng/L] and the HBO group [(306.64 ± 22.96) ng/L] were all higher than those of the model control group,while TRACP levels[(1735.48 ± 94.56) and (1889.63 ± 70.81) pg/L] were all lower than those of the model control group [(3453.69 ± 413.82)pg/L],with statistical significance (P ＜ 0.01).Conclusions HBO could affect bone metabolism in rats with premature ovary failure,had enhancing effect on BALP in bone formation,and at the same time had certain suppressing effect on TRACP in its role of bone absorption.