OBJECTIVE To explore the characteristics of the transient bilateral blindness caused by Iodixanol injection， analyze its occurrence mechanism， risk factors and treatment strategies， and provide references for the safe clinical use of Iodixanol injection. METHODS A retrospective analysis was conducted on the clinical data of a patient with bilateral vertebral artery stenosis who experienced transient bilateral blindness after receiving Iodixanol injection for interventional treatment. Based on this， combined with relevant literature from both domestic and international sources， a systematic analysis was carried out from aspects such as the correlation of adverse reactions， the mechanism of occurrence， risk factors， clinical characteristics， and treatment measures. RESULTS The patient received approximately 150 mL of Iodixanol injection during the operation. Blurred vision occurred 2 hours after the procedure， which gradually progressed to no light perception in both eyes， accompanied by headache， fever and transient renal dysfunction. According to the criteria for causality assessment of adverse drug reactions， the association between Iodixanol injection and transient bilateral blindness was assessed as “probable”. Combined with analysis of the present case and relevant literature， the underlying mechanisms were speculated to be related to blood-brain barrier disruption， immune reactions and microembolism. Risk factors included underlying cerebrovascular disease， renal insufficiency， high dose of contrast medium and atopic constitution. This adverse reaction was characterized by an acute onset， complex symptoms and obvious reversibility. After symptomatic treatments such as dehydration， anti-allergy therapy， fluid infusion and diuresis， as well as neurotrophic therapy， the patient’s vision recovered completely on the 5th day after surgery， and renal function also returned to the preoperative levels. CONCLUSIONS Transient bilateral blindness induced by Iodixanol injection is rare but clinically severe. At present， its exact pathogenesis has not been fully elucidated， and it involves a variety of risk factors. Before clinical administration， it is necessary to comprehensively evaluate the patient’s underlying diseases， renal function and allergy history； control the dosage of contrast medium during the operation； and closely monitor the patient’s condition after surgery. Once adverse reactions occur， timely intervention should be taken to improve the prognosis.

Objective To investigate the post-discharge exercise behavior and factors influencing moderate to vigorous intensity physical activity (MVPA) in patients undergoing lung surgery. Methods A total of 2874 patients from the large prospective, observational perioperative lung symptom study cohort (CN-PRO-Lung 3) in the Department of Thoracic Surgery at Sichuan Cancer Hospital between April 7, 2021, and January 31, 2024, were selected as the survey subjects. A survey was conducted using the Investigation of Exercise Behavior after Lung Surgery questionnaire and the International Physical Activity Questionnaire-Short Form (IPAQ-SF) among patients who underwent lung surgery. Binary logistic regression was used to analyze the factors influencing patients’ engagement in MVPA. Results A total of 702 patients were surveyed, including 252 males and 450 females, with an average age of (52.4±10.2) years. Patients with lung cancer accounted for 85.9%. Only 36.0% of the patients had regular exercise habits, while 42.3% did not engage in any physical activity. The three main barriers for postoperative exercise were physical discomfort (pain, coughing, shortness of breath, etc, 54.7%), lack of professional guidance (41.7%), and concerns about the surgical wound (28.9%). The proportions of patients engaging in vigorous, moderate, and low-intensity physical activity were 5.7%, 28.2%, and 66.1%, respectively. Multivariate analysis showed that patients with a personal annual income ≥50000 yuan (OR=1.52, 95%CI 1.01-2.29, P=0.044), high school education or above (OR=1.92, 95%CI 1.33-2.76, P<0.001), and lobectomy (OR=1.44, 95%CI 1.02-2.03, P=0.037) engaged in more MVPA. Conclusion Patients undergoing lung surgery have inadequate physical activity after discharge, particularly lacking in MVPA. Patients with higher income, higher educational levels, and lobectomy are more frequently engaged in MVPA. Measures such as symptom control, providing exercise guidance, and enhancing education on wound care may potentially improve the inadequate physical activity in lung surgery patients after discharge.

Objective:To explore the potential categories and characteristics of social alienation among family caregivers of patients with dementia, and to analyze the related influencing factors, providing reference for healthcare professionals to develop targeted intervention programs and improve the quality of care.Methods:A cross-sectional survey method was used to conveniently select family caregivers of dementia patients who were hospitalized or attended outpatient clinics at Tianyou Hospital Affiliated to Wuhan University of Science and Technology and the Central Theater General Hospital from December 2023 to July 2024 as survey objects. The general demographic information questionnaire, General Alienation Scale, Role Overload Scale, Adaptation, Partnership, Growth, Affection and Resolve, Type D Personality Scale-14, and Barthel Index were conducted for investigation. Latent profile analysis was used to explore potential categories of social alienation among family caregivers of people with dementia, and influential factors were explored through Logistic regression.Results:A total of 226 questionnaires were distributed and 220 valid questionnaires were collected, including 67 males and 153 females, with an age of (61.39 ± 9.42) years. The potential categories of social alienation of family caregivers of patients with dementia were categorized into low social alienation-low skepticism group (111 cases, 50.5%) and high social alienation-meaninglessness group (109cases, 49.5%). Patients′ age, self-care ability, dementia type, caregiver′s literacy, place of residence, occupational status, perceived health status, Length of care, per capita monthly family income, type D personality, role overload, and family caring were statistically different in the potential profile of social alienation ( t = 2.04, -16.48, 15.53; χ2 values were 3.84 - 109.23, all P< 0.05). Logistic regression analysis showed that the caregiver′s length of caregiving years (>5 years), role overload, family caring, type D personality (no), patient′s dementia type (mixed dementia), and self-care ability (mild dependence) were influential factors in the category of social alienation of family caregivers of patients with dementia ( OR values were 0.000 - 70.970, all P<0.05). Conclusions:There is group heterogeneity in the social alienation of family caregivers of patients with dementia, and healthcare professionals should focus on the differences in the type of disease, self-care ability, and years of caregiving experience of caregivers, and formulate personalized and precise interventions from caregiver personality traits, role overload, and family care to reduce the level of their social alienation.

Objective:To visualize and analyze the scientific achievements of psychological distress of family caregivers for patients with dementia based on Web of Science, to clarify the current research status, hotspots, and frontiers in this field.Methods:The literature on psychological distress of family caregivers for patients with dementia collected in the core collection of Web of Science from 2005 to 2024 were retrieved. VOSviewer, CiteSpace, BICOMB, gCLUTO were used to analyze the annual number of publications, countries, institutions, authors, journals and keywords.Results:A total of 794 articles were included, and the overall number of articles was on the rise. A total of 41 countries published articles. United States had the largest number (251 articles) and the closest cooperation with other countries. The institution with the largest number of publications was from United Kingdom (42 articles), the authors with the largest output were from United States and Spain (both 12 articles), and the journal with the largest number of publications was Aging & Mental Health (53 articles). Five clusters: psychological distress performance; mental and behavioral symptoms associated with dementia patients; a systematic review of family care for dementia patients; the relationship between psychological distress and care burden, quality of life, mental health; the influence of psychological distress on family caregivers of dementia patients were obtained by keyword clustering analysis. The most prominent keyword was "individual", "acceptance and commitment therapy" and "reliability" were emerging burst keywords. Conclusions:United States and United Kingdom are in a leading position in the field, and the research in China lacks international cooperation. Psychological distress performance and the relationship between psychological distress and care burden, quality of life, mental health are the current research hotspots. Acceptance and commitment therapy reliability research and personalized interventions are research trends.

Objective:To explore the potential categories and characteristics of social alienation among family caregivers of patients with dementia, and to analyze the related influencing factors, providing reference for healthcare professionals to develop targeted intervention programs and improve the quality of care.Methods:A cross-sectional survey method was used to conveniently select family caregivers of dementia patients who were hospitalized or attended outpatient clinics at Tianyou Hospital Affiliated to Wuhan University of Science and Technology and the Central Theater General Hospital from December 2023 to July 2024 as survey objects. The general demographic information questionnaire, General Alienation Scale, Role Overload Scale, Adaptation, Partnership, Growth, Affection and Resolve, Type D Personality Scale-14, and Barthel Index were conducted for investigation. Latent profile analysis was used to explore potential categories of social alienation among family caregivers of people with dementia, and influential factors were explored through Logistic regression.Results:A total of 226 questionnaires were distributed and 220 valid questionnaires were collected, including 67 males and 153 females, with an age of (61.39 ± 9.42) years. The potential categories of social alienation of family caregivers of patients with dementia were categorized into low social alienation-low skepticism group (111 cases, 50.5%) and high social alienation-meaninglessness group (109cases, 49.5%). Patients′ age, self-care ability, dementia type, caregiver′s literacy, place of residence, occupational status, perceived health status, Length of care, per capita monthly family income, type D personality, role overload, and family caring were statistically different in the potential profile of social alienation ( t = 2.04, -16.48, 15.53; χ2 values were 3.84 - 109.23, all P< 0.05). Logistic regression analysis showed that the caregiver′s length of caregiving years (>5 years), role overload, family caring, type D personality (no), patient′s dementia type (mixed dementia), and self-care ability (mild dependence) were influential factors in the category of social alienation of family caregivers of patients with dementia ( OR values were 0.000 - 70.970, all P<0.05). Conclusions:There is group heterogeneity in the social alienation of family caregivers of patients with dementia, and healthcare professionals should focus on the differences in the type of disease, self-care ability, and years of caregiving experience of caregivers, and formulate personalized and precise interventions from caregiver personality traits, role overload, and family care to reduce the level of their social alienation.

Objective:To visualize and analyze the scientific achievements of psychological distress of family caregivers for patients with dementia based on Web of Science, to clarify the current research status, hotspots, and frontiers in this field.Methods:The literature on psychological distress of family caregivers for patients with dementia collected in the core collection of Web of Science from 2005 to 2024 were retrieved. VOSviewer, CiteSpace, BICOMB, gCLUTO were used to analyze the annual number of publications, countries, institutions, authors, journals and keywords.Results:A total of 794 articles were included, and the overall number of articles was on the rise. A total of 41 countries published articles. United States had the largest number (251 articles) and the closest cooperation with other countries. The institution with the largest number of publications was from United Kingdom (42 articles), the authors with the largest output were from United States and Spain (both 12 articles), and the journal with the largest number of publications was Aging & Mental Health (53 articles). Five clusters: psychological distress performance; mental and behavioral symptoms associated with dementia patients; a systematic review of family care for dementia patients; the relationship between psychological distress and care burden, quality of life, mental health; the influence of psychological distress on family caregivers of dementia patients were obtained by keyword clustering analysis. The most prominent keyword was "individual", "acceptance and commitment therapy" and "reliability" were emerging burst keywords. Conclusions:United States and United Kingdom are in a leading position in the field, and the research in China lacks international cooperation. Psychological distress performance and the relationship between psychological distress and care burden, quality of life, mental health are the current research hotspots. Acceptance and commitment therapy reliability research and personalized interventions are research trends.

This report summarises the experience of nursing care for a patient with compression of the inferior vena cava caused by a huge liver abscess of fusobacterium necrophorum infection.The nursing measures included the care of blood shunting,care of pus liquefaction and drainage,management of fluid therapy and continuous renal replacement therapy,as well as observation and nursing of the drug therapy.With meticulous in treatment and care,the patient recovered and discharged from the hospital after a 19-day hospital stay.

The innate immune sensor NLRP3 inflammasome overactivation is involved in the pathogenesis of ulcerative colitis. PGAM5 is a mitochondrial phosphatase involved in NLRP3 inflammasome activation in macrophages. However, the role of PGAM5 in ulcerative colitis and the mechanisms underlying PGAM5 regulating NLRP3 activity remain unknown. Here, we show that PGAM5 deficiency ameliorates dextran sodium sulfate (DSS)-induced colitis in mice via suppressing NLRP3 inflammasome activation. By combining APEX2-based proximity labeling focused on PGAM5 with quantitative proteomics, we identify NEK7 as the new binding partner of PGAM5 to promote NLRP3 inflammasome assembly and activation in a PGAM5 phosphatase activity-independent manner upon inflammasome induction. Interfering with PGAM5-NEK7 interaction by punicalagin inhibits the activation of the NLRP3 inflammasome in macrophages and ameliorates DSS-induced colitis in mice. Altogether, our data demonstrate the PGAM5-NEK7 interaction in macrophages for NLRP3 inflammasome activation and further provide a promising therapeutic strategy for ulcerative colitis by blocking the PGAM5-NEK7 interaction.

The neonatal mammalian heart has a remarkable regenerative capacity, while the adult heart has difficulty to regenerate. A metabolic reprogramming from glycolysis to fatty acid oxidation occurs along with the loss of cardiomyocyte proliferative capacity shortly after birth. In this study, we sought to determine if and how metabolic reprogramming regulates cardiomyocyte proliferation. Reversing metabolic reprogramming by carnitine palmitoyltransferase 1 (CPT1) inhibition, using cardiac-specific Cpt1a and Cpt1b knockout mice promoted cardiomyocyte proliferation and improved cardiac function post-myocardial infarction. The inhibition of CPT1 is of pharmacological significance because those protective effects were replicated by etomoxir, a CPT1 inhibitor. CPT1 inhibition, by decreasing poly(ADP-ribose) polymerase 1 expression, reduced ADP-ribosylation of dual-specificity phosphatase 1 in cardiomyocytes, leading to decreased p38 MAPK phosphorylation, and stimulation of cardiomyocyte proliferation. Our present study indicates that reversing metabolic reprogramming is an effective strategy to stimulate adult cardiomyocyte proliferation. CPT1 is a potential therapeutic target for promoting heart regeneration and myocardial infarction treatment.