Objective: The scientific literature indicates that there is a correlation between spiritual well-being and stress. However, there is a paucity of knowledge about the interrelationships between these two factors within the context of a Christian community. The objective of this study was to determine the relationship between spiritual well-being and stress in a sample of Peruvian Christians. Methods: This was a cross-sectional and correlational study. The sample consisted of 250 members of a Christian community in southern Peru. The sample was selected by nonprobabilistic purposive sampling. The Spiritual Well-Being Scale (SWBS) and the Stress Scale (SS-7) were used. Results: Negative and statistically significant correlation were found between spiritual well-being religious well-being and existential well-being with stress (p<0.001). The multiple regression analysis showed that spiritual well-being and sex accounted for 27.8% of the variance in stress levels (adjusted R2=0.278). Spiritual well-being (β=-0.512, p<0.001) has a significant negative effect on stress, while being female (β=0.114, p=0.035) is associated with higher stress levels compared to being male. The moderation effect was not significant, indicating that spiritual well-being influences stress similarly across both sexes (b=-0.0303, standard error=0.0405, t=-0.7469, p=0.456). Conclusion These findings support the integration of spiritual well-being into interventions for mental health promotion and prevention with an emphasis on stress; and confirm that the spirituality component of Christians can play an important role in lowering stress levels.

Objective: The scientific literature indicates that there is a correlation between spiritual well-being and stress. However, there is a paucity of knowledge about the interrelationships between these two factors within the context of a Christian community. The objective of this study was to determine the relationship between spiritual well-being and stress in a sample of Peruvian Christians. Methods: This was a cross-sectional and correlational study. The sample consisted of 250 members of a Christian community in southern Peru. The sample was selected by nonprobabilistic purposive sampling. The Spiritual Well-Being Scale (SWBS) and the Stress Scale (SS-7) were used. Results: Negative and statistically significant correlation were found between spiritual well-being religious well-being and existential well-being with stress (p<0.001). The multiple regression analysis showed that spiritual well-being and sex accounted for 27.8% of the variance in stress levels (adjusted R2=0.278). Spiritual well-being (β=-0.512, p<0.001) has a significant negative effect on stress, while being female (β=0.114, p=0.035) is associated with higher stress levels compared to being male. The moderation effect was not significant, indicating that spiritual well-being influences stress similarly across both sexes (b=-0.0303, standard error=0.0405, t=-0.7469, p=0.456). Conclusion These findings support the integration of spiritual well-being into interventions for mental health promotion and prevention with an emphasis on stress; and confirm that the spirituality component of Christians can play an important role in lowering stress levels.

Objective: The scientific literature indicates that there is a correlation between spiritual well-being and stress. However, there is a paucity of knowledge about the interrelationships between these two factors within the context of a Christian community. The objective of this study was to determine the relationship between spiritual well-being and stress in a sample of Peruvian Christians. Methods: This was a cross-sectional and correlational study. The sample consisted of 250 members of a Christian community in southern Peru. The sample was selected by nonprobabilistic purposive sampling. The Spiritual Well-Being Scale (SWBS) and the Stress Scale (SS-7) were used. Results: Negative and statistically significant correlation were found between spiritual well-being religious well-being and existential well-being with stress (p<0.001). The multiple regression analysis showed that spiritual well-being and sex accounted for 27.8% of the variance in stress levels (adjusted R2=0.278). Spiritual well-being (β=-0.512, p<0.001) has a significant negative effect on stress, while being female (β=0.114, p=0.035) is associated with higher stress levels compared to being male. The moderation effect was not significant, indicating that spiritual well-being influences stress similarly across both sexes (b=-0.0303, standard error=0.0405, t=-0.7469, p=0.456). Conclusion These findings support the integration of spiritual well-being into interventions for mental health promotion and prevention with an emphasis on stress; and confirm that the spirituality component of Christians can play an important role in lowering stress levels.

Objective: The scientific literature indicates that there is a correlation between spiritual well-being and stress. However, there is a paucity of knowledge about the interrelationships between these two factors within the context of a Christian community. The objective of this study was to determine the relationship between spiritual well-being and stress in a sample of Peruvian Christians. Methods: This was a cross-sectional and correlational study. The sample consisted of 250 members of a Christian community in southern Peru. The sample was selected by nonprobabilistic purposive sampling. The Spiritual Well-Being Scale (SWBS) and the Stress Scale (SS-7) were used. Results: Negative and statistically significant correlation were found between spiritual well-being religious well-being and existential well-being with stress (p<0.001). The multiple regression analysis showed that spiritual well-being and sex accounted for 27.8% of the variance in stress levels (adjusted R2=0.278). Spiritual well-being (β=-0.512, p<0.001) has a significant negative effect on stress, while being female (β=0.114, p=0.035) is associated with higher stress levels compared to being male. The moderation effect was not significant, indicating that spiritual well-being influences stress similarly across both sexes (b=-0.0303, standard error=0.0405, t=-0.7469, p=0.456). Conclusion These findings support the integration of spiritual well-being into interventions for mental health promotion and prevention with an emphasis on stress; and confirm that the spirituality component of Christians can play an important role in lowering stress levels.

Objective: The scientific literature indicates that there is a correlation between spiritual well-being and stress. However, there is a paucity of knowledge about the interrelationships between these two factors within the context of a Christian community. The objective of this study was to determine the relationship between spiritual well-being and stress in a sample of Peruvian Christians. Methods: This was a cross-sectional and correlational study. The sample consisted of 250 members of a Christian community in southern Peru. The sample was selected by nonprobabilistic purposive sampling. The Spiritual Well-Being Scale (SWBS) and the Stress Scale (SS-7) were used. Results: Negative and statistically significant correlation were found between spiritual well-being religious well-being and existential well-being with stress (p<0.001). The multiple regression analysis showed that spiritual well-being and sex accounted for 27.8% of the variance in stress levels (adjusted R2=0.278). Spiritual well-being (β=-0.512, p<0.001) has a significant negative effect on stress, while being female (β=0.114, p=0.035) is associated with higher stress levels compared to being male. The moderation effect was not significant, indicating that spiritual well-being influences stress similarly across both sexes (b=-0.0303, standard error=0.0405, t=-0.7469, p=0.456). Conclusion These findings support the integration of spiritual well-being into interventions for mental health promotion and prevention with an emphasis on stress; and confirm that the spirituality component of Christians can play an important role in lowering stress levels.

Cancers have high morbidity and mortality rates worldwide. Current anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of carcinogenesis. Autophagy is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis, exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant cells. Therefore, drugs aimed at autophagy can function as antitumor agents. Flavonoids are a class of polyphenolic secondary metabolites commonly found in plants and, consequently, consumed in diets. In this review, the systematic search strategy was used, which included the search for descriptors "flavonoids" AND "mTOR pathway" AND "cancer" AND "autophagy", in the electronic databases of PubMed, Cochrane Library, Web of Science and Scopus, from January 2011 to January 2021. The current literature demonstrates that flavonoids have anticarcinogenic properties, including inhibition of cell proliferation, induction of apoptosis, autophagy, necrosis, cell cycle arrest, senescence, impaired cell migration, invasion, tumor angiogenesis and reduced resistance to multiple drugs in tumor cells. We demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition. (Registration No. CRD42021243071 at PROSPERO).
Humans ; Flavonoids/pharmacology* ; Neoplasms ; Antineoplastic Agents/pharmacology* ; Signal Transduction ; Apoptosis ; Cell Proliferation ; Carcinogenesis ; Cell Line, Tumor

Objective: To evaluate the antinociceptive activity of perillyl acetate in mice and in silico simulations. Methods: The vehicle, perillyl acetate (100, 150 and/or 200 mg/kg, i.p.), diazepam (2 mg/kg, i.p.) or morphine (6 mg/kg, i.p.) was administered to mice, respectively. Rotarod test, acetic acid-induced abdominal writhing, formalin-induced nociception, hot plate test, and tail-flick test were performed. Opioid receptors-involvement in perillyl acetate antinociceptive effect was also investigated. Results: Perillyl acetate did not affect the motor coordination of mice. However, it reduced the number of acetic acid-induced abdominal twitches and licking times in the formalin test. There was an increase of latency time in the tail-flick test of 30 and 60 minutes. Pretreatment with naloxone reversed the antinociceptive effect of perillyl acetate (200 mg/kg). In silico analysis demonstrated that perillyl acetate could bind to μ-opioid receptors. Conclusions: Perillyl acetate has antinociceptive effect at the spinal level in animal nociception models, without affecting the locomotor integrity and possibly through μ-opioid receptors. In silico studies have suggested that perillyl acetate can act as a μ-opioid receptor agonist.

Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been reported that the HTLV-1 proteins (specifically TAX and HBZ) can modulate FOXp3, resulting in an immune imbalance that can favor the progression of HAM/TSP. This review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 mRNAs and/or viral proteins (TAX and HBZ) with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP development. This systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. The search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject descriptors. After screening, six articles were included in this review. The studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP, which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy donors. This systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development.

BACKGROUND: The prevalence of flap necrosis after palatoplasty in patients with cleft palate. The prevalence of mucoperiosteal flap necrosis after palatoplasty remains unknown, and this complication is rare. This event is highly undesirable for both the patient and the surgeon. We present here a new scale to evaluate the degree of hypoplasia of the palate and identify patients with cleft palate at high risk for the development of this complication. METHODS: In this case series, a 20-year retrospective analysis (1994–2014) identified patients from our records (medical records and screening day registries) with nonsyndromic cleft palate who underwent operations at 3 centers. All of these patients underwent operations using 2-flap palatoplasty and also underwent a physical examination with photographs and documentation of the presence of palatal flap necrosis after primary palatoplasty. RESULTS: Palatal flap necrosis was observed in 4 cases out of 1,174 palatoplasties performed at these centers. The observed prevalence of palatal flap necrosis in these groups was 0.34%. CONCLUSIONS: The prevalence of flap necrosis can be reduced by careful preoperative planning, and prevention is possible. The scale proposed here may help to prevent this complication; however, further studies are necessary to validate its utility.
Cleft Palate* ; Craniofacial Abnormalities ; Humans ; Mass Screening ; Necrosis* ; Palate ; Physical Examination ; Prevalence ; Retrospective Studies

PURPOSE: The aim of this study was to determine whether two methods of documentation, print and electronic forms, for the assessment of patient-reported outcomes (PRO) in complete denture wearers provide comparable results. The study also quantified the time needed for filling the forms by each method. MATERIALS AND METHODS: Thirty participants enrolled in a university clinic answered two forms (a questionnaire for denture satisfaction and OHIP-EDENT). They provided answers with two application methods in a random order, with a one-month interval between them: (1) electronic forms on a tablet computer; and (2) print forms. The methods were compared in terms of mean results, correlation/agreement, internal consistency, and spent time. RESULTS: Mean results for both methods were similar for each denture satisfaction item (100-mm VAS) and OHIP-EDENT summary score. Both questionnaires presented good internal consistency regardless of the application method (Cronbach's α=0.86 or higher). Correlation and agreement between the methods regarding specific items was at least moderate for the majority of cases. Mean time for the electronic and print forms were 9.2 and 8.5 minutes, respectively (paired t test, P=.06, non-significant). CONCLUSION: The electronic method is comparable to print forms for the assessment of important PRO of prosthetic treatment for edentulism, considering the results and time needed. Findings suggest the viability of replacing print forms with a tablet for applying the tested inventories in clinical trials.
Computers, Handheld* ; Denture, Complete ; Dentures ; Equipment and Supplies ; Humans ; Methods ; Patient Satisfaction ; Quality of Life ; Treatment Outcome