Objective: To investigate the detection rates of overweight and obesity among employed workers in Shaoxing City, Zhejiang Province, so as to provide a basis for formulating weight management intervention strategies for occupational population. Methods: Physical examination data of employed workers aged 18-59 years in 2024, including demographic information, height and weight were collected through the health management platform of the physical examination information systems of 20 designated physical examination hospitals in Shaoxing City. Overweight and obesity were determined according to the Criteria of Weight for Adults, and the detection rates of overweight and obesity were calculated and standardized using the data from the Sixth National Population Census in 2010. The gender- and age-specific detection rates of overweight and obesity among employed workers were analyzed. Results: A total of 201 066 employed workers were included, with a mean age of (40.90±11.60) years. There were 107 682 males (53.56%) and 93 384 females (46.44%). A total of 64 224 cases of overweight were detected, with a detection rate of 31.94% and a standardized detection rate of 30.19%. A total of 22 727 cases of obesity were detected, with a detection rate of 11.30% and a standardized detection rate of 11.47%. The standardized detection rates of overweight and obesity were higher in males than in females (38.46% vs. 20.21%, 6.13% vs. 5.80%). The detection rate of overweight increased with age (P<0.05), with the higher rate observed in the group aged 55-59 years (38.27%). The detection rates of overweight among both males and females increased with age (both P<0.05). The detection rate of obesity first increased and then decreased with age, with the higher rates in the groups aged 30-<35 years (12.37%) and 35-<40 years (12.33%). The detection rate of obesity among males first increased and then decreased with age, with the higher rates observed in the groups aged 30-<35 years (17.96%) and 35-<40 years (17.99%). The detection rate of obesity among females first decreased and then increased with age, with the higher rates observed in the group aged 55-59 years (7.77%). Conclusions The detection rates of overweight and obesity were higher in male employed workers than those in female in Shaoxing City. The detection rate of overweight increased with age, while the detection rate of obesity showed an inverted U-shaped trend. Males aged 30-<40 years and females aged 55-59 years should be prioritized for obesity prevention and control.

Objective: To investigate the current status and influencing factors of falls among the elderly in Shaoxing City, Zhejiang Province, so as to provide evidence for developing fall prevention and intervention strategies for the elderly. Methods: From April 2023 to October 2025, residents aged ≥60 years in Shaoxing City were selected as study participants using multi-stage stratified random cluster sampling. Data on demographic characteristics, lifestyle behaviors, chronic diseases, body mass index (BMI), and falls in the past 1 year were collected through questionnaires and physical examinations.The Chinese version of the Frail Scale and the EuroQoL five-dimensions three-levels questionnaire were used to assess frailty status and health related quality of life, respectively. The incidence of falls among the elderly was analyse. A multivariable logistic regression model was used to analyze the influencing factors of falls. Results: A total of 4 095 participants were surveyed. The mean age of participants was (71.17±6.89) years. There were 1 773 males (43.30%) and 2 322 females (56.70%). Falls were identified in 465 participants, with an incidence of 11.36%. Multivariable logistic regression analysis showed that unmarried/divorced/widowed (OR=1.263, 95%CI: 1.003-1.590), daily sedentary time ≥6 hours (OR=1.349, 95%CI: 1.050-1.733), pre-frailty (OR=2.316, 95%CI: 1.872-2.864) and frailty (OR=4.268, 95%CI: 2.577-7.068) had a higher risk of falls; junior high school or above education level (junior high school, OR=0.669, 95%CI: 0.484-0.926; high school and above, OR=0.413, 95%CI: 0.189-0.901), annual household income of 20 000-<100 000 yuan (20 000-<50 000 yuan, OR=0.699, 95%CI: 0.535-0.911; 50 000-<100 000 yuan, OR=0.669, 95%CI: 0.476-0.940), and higher health related quality of life (OR=0.076, 95%CI: 0.036-0.160) had a lower risk of falls. Conclusions The incidence of falls among the elderly in Shaoxing City was 11.36%. Falls were possibly associated with marital status, educational level, annual household income, daily sedentary time, frailty status and health related quality of life.

Objective:To explore the correlation between fasting plasma glucose (FPG) trajectory and new-onset chronic kidney disease (CKD) in elderly population (≥65 years old) in Nanjing.Methods:The study cohort was composed of 14 763 subjects who met the inclusion criteria in the population in elderly health examination in Nanjing. Based on the FPG levels detected in health examination from 2018 to 2021 (logarithm was used for normal distribution), three different FPG trajectory groups were determined using the SAS Proc Traj program, i.e. low-stable group, medium-stable group, and high-stable group. The incidence of CKD in 2022 was analyzed, and log-rank test was performed to compare the differences of cumulative incidence of new-onset CKD among different trajectory groups. Cox proportional hazards regression model was used to analyze the correlation between different FPG trajectories and new-onset CKD.Results:The mean follow-up time was (416.09±81.96) days. The follow-up time of the 500 th day was selected to analyze the cumulative incidence rate of CKD in different FPG trajectory groups, and the cumulative incidence rate of CKD in the low-stable group, the medium-stable group, and the high-stable group of FPG increased with elevated trajectory, which was 15.3%, 21.8%, and 29.3%, respectively (log-rank test χ2=151.16, P<0.001). Cox proportional hazards regression model analysis showed that compared with the low-stable group, the medium-stable group and the high-stable group were all at risk for new-onset CKD. After adjusting for multiple confounding factors, the analysis by Cox proportional hazards regression model 4 indicated that the risk for CKD in medium-stable and high-stable groups were still 1.676 (95% CI: 1.462-1.921) times and 2.007 (95% CI: 1.562-2.579) times higher than that in low-stable group. Conclusions:Elevated FPG change trajectory level is a risk factor for new-onset CKD, and persistently high level of FPG increase the risk for CKD. FPG should be monitored in elderly population by follow up, and individualized prevention and control measures for CKD should be developed for different trajectory groups.

【Objective】 To investigate the willingness of whole blood donors to donate apheresis platelets and analyze its influencing factors. 【Methods】 A total of 400 whole blood donors from Kunshan Blood Station and Leshan Blood Station from January to May, 2023 were surveyed by random sampling, and their willingness to donate apheresis platelets were analyzed by univariate analysis and binary logistic regression analysis. 【Results】 A total of 386 valid questionnaires were collected, with a recovery rate of 96.5%. Among the 386 whole blood donors, 177 were willing to donate apheresis platelets, accounting for 45.9%. Univariate analysis showed that gender, age, education level, blood donation times, average blood donation volume, adverse reactions to blood donation, understanding of platelets, and family members' attitude towards blood donation were the main factors affecting the willingness of whole blood donors to donate platelets, and binary logistic regression analysis showed that gender, age, blood donation times, average blood donation volume, understanding of platelets and family members' attitude towards blood donation were the main factors. 【Conclusion】 Targeted recruitment of whole blood donors should be conducted to recruit more apheresis platelet donors, so as to meet clinical demand of apheresis platelets.

Objective To evaluate the therapeutic effect of chemotherapeutic drugs on pancreatic carcinoma based on patient-derived xenograft(PDX)models,and to screen an individualized treatment strategy. Methods Fresh human pancreatic carcinoma tissues were subcutaneously transplanted into nude mice to establish PDX models which could be stab-ly passaged. The traceability of PDX models was determined by STR analysis. The PDX models were treated with three dif-ferent clinical chemotherapeutic drugs oxaliplatin, gemcitabine and irinotecan, respectively, and the tumor volumes were measured at different times. The therapeutic effect of those drugs was assessed by TGD mathematical model and plasma CA19-9 test. Results The traceability of patient-derived xenograft samples was up to 99.99%. Compared with the con-trol group,the treatment with irinotecan and gemcitabine inhibited tumor growth significantly(P=0.001), and gemcit-abine had even better result. The minimum toxic effect in the mice was induced by irinotecan treatment,followed by gem-citabine treatment. Conclusions Pancreatic carcinoma PDX models are successfully established and can be stably pas-saged. Gemcitabine shows the most inhibitory effect on tumor growth based on TGD mathematical model assessment, and deserves to be recommended as the preferred drug for individual treatment of pancreatic carcinoma.

Hematopoietic stem cell transplantation has a good clinical effect on the treatment of hematologic malignancies, but during the treatment, it will bring relevant negative psychology to the patient' s psychology and body. This paper analyzed the psychological obstacles often emerging during the treatment of hematopoietic stem cell transplantation, as well as the family members' negative psychological emotion caused by the long-term psychological pressure and economic pressure, and further analyzed the reasons for the psychological problems in the patients and the corresponding nursing methods, and the causes of the psychological disorders of the patients' families and the corresponding nursing methods. In addition, health education was adopted for patients and their family members, and through the methods of doctor-patient communication, disease education, behavior training and so on, this paper found that after the implementation of health education for patients and their family members, the postoperative recovery rate of transplanted patients was obviously improved, and their psychological problems were also obviously alleviated and eliminated. It was proved that health education had a good therapeutic effect on the psychological problems of hematopoietic stem cell transplantation patients and their family member, and was worthy of promotion in clinical practice.

Objective: To observe the parameters of the results of suppression head impulse paradigm (SHIMP) in healthy adults, and to provide reference for evaluating vestibular oculomotor reflex function in patients with peripheral vertigo. Methods: Fifty healthy adults, 22 males and 28 females, aged from 23-65 years, with an average age of (38.5±11.6) years, were recruited from January to March 2018. Parameters provided by the video head pulse software included the gains, the latency and the peak velocity of saccades, and comparison was made with head impulse paradigm (HIMP). Results: All subjects were elicited anti-compensatory saccades in SHIMP. The normal values of left and right gains were 1.02 and 1.10 in HIMP, and 0.93 and 1.01 in SHIMP respectively. The left and right saccades latency were (201.1± 50.8)ms and (187.0± 42.9)ms, and the peak saccadic velocity were (302.7±58.5)°/s and (291.5±46.5)°/s in SHIMP; there were small but significant difference between two sides about gains in HIMP and SHIMP, as well as latency in SHIMP(P<0.05); there were small but significant difference between HIMP and SHIMP about gains in ipsilateral(P<0.01); there were no significant difference between two sides about peak saccadic velocity in SHIMP(P>0.05). Conclusions SHIMP can be used for the examination of vestibular oculomotor reflex function in adult population. It is easy to be operated and is convenient for clinical application. Combined with head pulse test, the function of the semicircular canal can be evaluated together.

Objective To explore the clinical value of nodal metastatic characteristics in predicting the distant metastasis of papillary thyroid carcinoma (PTC).Methods A total of 1 408 PTC patients who met the inclusion criteria and received initial thyroidectomy at our department from January 2006 to December 2011 were enrolled in this study.Results After a median follow-up time of 7.8 years,distant metastases developed in 46 patients.Patients with lateral neck lymph node metastasis ≥7,individual size of lateral neck lymph node metastasis ≥ 1.15 cm and the total number of cervical lymph node metastasis ≥9 were prone to higher risk of distant metastasis;the high risk group had a lower 10-year distant metastasisfree survival (78.7％ vs.98％,x2 =122.941,P ＜0.01) and a shorter distant metastasis-free survival time (99.2 M vs.122.5 M,x2 =122.941,P ＜ 0.01).Conclusions Lateral lymph node metastasis is an independent risk factor for distant metastasis in PTC patients.

Objective To investigate the therapeutic effect of early stage minimally invasive laparoscopic retroperitoneal approach of catheter drainage on early inflammatory response of severe acute pancreatitis ( SAP ) . Methods 37 SAP patients with peritoneal effusion were divided into the observation group (19 cases with early laparoscopic retroperitoneal approach of catheter drainage )and normal treatment group(18 cases with conventional drainage)using a random number table.All patients were given conventional therapy , such as fasting, gastroin-testinal decompression , anti-infection, fluid resuitation and using gastric acid and trypsin inhibitors .In addition to conventional therapy , the observation group received the early laparoscopic retroperitoneal approach of catheter drainage.The inflammatory indexes responding to acute inflammation such as TNF-α,IL-6,IL-8, IL-10 and C-re-active protein(CRP)were detected before and after treatment .Meanwhile, the date of resume diet, APACHEⅡscores and duration of systemic inflammatory response ( SIRS) , incidence of multiple organ dysfunction syndrome ( MODS) and the mortality were observed .Results The acute inflammatory response occurred in both groups . The plasma levels of TNF-a,IL-6,IL-8,IL-10 and CRP in the two groups decreased obviously after 3-day treat-ment.However, the plasma levels of inflammatory mediators in the normal treatment group increased while those early laparoscopic retroperitoneal approach of catheter drainage group kept decreasing after 7-day treatment .There was a significant difference between the two groups (P<0.01).Time for resuming to diets and duration of SIRS in the observation group were less than those in the normal treatment group ( P<0.01 ) , APACHEⅡscore were significantly less than those in normal treatment group also (P<0.01).The rates of MODS, overall postoperative complication rate and mortality were significantly lower in the observation group (P<0.05).Conclusions Early laparoscopic retroperitoneal approach of catheter drainage can effectively improve the prognosis in patients with SAP and decrease the production of inflammatory mediators .Early laparoscopic retroperitoneal approach of cathe-ter drainage is simple , feasible and micro-invasive with encouraging outcomes , therefore it is an effective and safe treatment option for patients with SAP .

Objective To investigate the feasibility and clinical value of the road drainage after early mini-mally invasive treatment of severe acute pancreatitis (severe acute pancreatitis,SAP).Methods A retrospective analysis were used to investigate the clinical data of 37 patients with SAP in March 2011 to March 2011 after conven-tional treatment and early minimally invasive approach drainage treatment.Drainage of early after minimally invasive approach group were treated by laparoscopic retroperitoneal approach surgery in the early onset,and were removed of necrotic tissue and catheter drainage of the retroperitoneal clearance.Then postoperative double pipe for irrigation and the negative pressure drainage were applied.Two groups of postoperative complications,mortality,medical expenses, length of hospital stay,etc.were compared.Results Early minimally invasive drainage of into the road after acute physiology and chronic health evaluation (APACHE Ⅱ)was superior to the conventional treatment group (P =0.00).The overall incidence of complications and mortality of multiple organ dysfunction syndrome (multiple out-raged dysfunction syndrome,MODS),was superior to the conventional treatment group,and the differences were statis-tically significant (P =0.023,P =0.033,P =0.046).Early into the road drainage of hospitalization expenses after minimally invasive were reduced ((19.74 ±2.22)than (36.15 ±1.92)ten thousand yuan,t =23.989,P =0.000),hospitalization time were shorter (4.76 ±0.64)weeks than (6.03 ±0.73)weeks,t =5.635,P =0.000). Conclusion Early minimally invasive retroperitoneal approach of drainage treatment of SAP can reduce the incidence of complications and mortality,reduce hospitalization expenses,shorten hospitalization time,and has the clinical feasi-bility and application value.