Objective: To develop a prediction model for mild cognitive impairment (MCI) risk among the elderly, so as to provide a tool for MCI early screening. Methods : From July 2022 to September 2024, a multi-stage stratified random cluster sampling method was used to recruit permanent residents aged ≥65 years from the Xinjiang Uygur Autonomous Region as study participants. Data on sociodemographic characteristics, nutritional status, body composition indices, bone mineral density, and handgrip strength were collected through questionnaires and physical examinations. Sarcopenia was defined based on appendicular skeletal muscle index and handgrip strength. MCI was assessed using the Mini-Mental State Examination, with adjustments for educational level. Participants were randomly divided into a training set and a validation set in a 7∶3 ratio. LASSO regression and multivariable logistic regression models were employed to screen for predictors and construct an MCI risk prediction model. The predictive performance of the model was evaluated using receiver operating characteristic (ROC) curve and decision curve analysis (DCA). Results: A total of 1 641 participants were surveyed, including 755 males (46.01%) and 886 females (53.99%). The majority of participants were aged 65-<75 years, comprising 1 154 individuals (70.32%). MCI was detected in 517 participants, corresponding to a detection rate of 31.51%. Resultsfrom LASSO regression and multivariate logistic regression analysis showed that residence (rural, OR = 2.323, 95% CI: 1.682-3.210), age (75-<85 years, OR = 1.405, 95% CI: 1.019-1.937; ≥85 years, OR = 3.655, 95% CI: 1.696-7.875), educational level (primary school, OR = 0.341, 95% CI: 0.247-0.472; junior high school, OR = 0.255, 95% CI: 0.160-0.408; high school, OR = 0.286, 95% CI: 0.154-0.531; bachelor's degree or above, OR = 0.120, 95% CI: 0.041-0.351), history of alcohol consumption (yes, OR = 3.216, 95% CI: 2.164-4.779), risk of malnutrition (yes, OR = 1.464, 95% CI: 1.064-2.014), sarcopenia (yes, OR = 3.197, 95% CI: 2.332-4.385), and waist-to-hip ratio (abnormal, OR = 1.540, 95% CI: 1.159-2.048) were identified as predictive factors for MCI among the elderly. In the training set, the area under the ROC curve, sensitivity, and specificity were 0.788, 0.719, and 0.712, respectively. In the validation set, the corresponding values were 0.784, 0.913, and 0.542, respectively. DCA demonstrated that the model provided a higher clinical net benefit for predicting MCI risk when the risk threshold probability ranged from 0.124 to 0.764. Conclusion The prediction model developed in this study demonstrates good discriminative ability and clinical utility, indicating its substantial value for predicting the MCI risk among the elderly.

Objective:To explore the mediating effect of social support and exercise self-efficacy on the intrinsic capacity of community-dwelling older adults and healthy aging, so to provide a basis for improving the healthy aging of community-dwelling older adults.Methods:From January to July 2022, cluster random sampling was used to select 1 303 community-dwelling older adults from Urumqi City as the research subject. The survey was conducted using the General Information Questionnaire, Healthy Aging Instrument, Intrinsic Capacity Questionnaire, Social Support Rating Scale, and Exercise Self Efficacy Scale for Aged People in Community. The conceptual model was used to explore the relationship among social support, exercise self-efficacy, intrinsic capacity, and healthy aging in community-dwelling older adults. A total of 1 303 questionnaires were distributed, and 1 042 valid questionnaires were collected, with an effective response rate of 80%.Results:Among 1 042 community-dwelling older adults, the scores of the Intrinsic Capacity Questionnaire, Healthy Aging Instrument, Social Support Rating Scale, and Exercise Self Efficacy Scale for Aged People in Community were [1.00 (0, 2.00) ] , [146.00 (133.75, 155.00) ] , [41.00 (36.00, 46.00) ] and [51.00 (39.00, 61.00) ] , respectively. The intrinsic capacity of community-dwelling older adults was negatively correlated with social support, exercise self-efficacy, and healthy aging ( r=-0.112, -0.121, -0.120, P<0.01) , and social support and exercise self-efficacy were positively correlated with healthy aging (r=0.129, 0.113, P<0.01) . Bootstrap mediating effect test showed that the mediating effect of social support and exercise self-efficacy between the intrinsic capacity of community-dwelling older adults and healthy aging was established, with a mediating effect value of -0.477, accounting for 24.75% of the total effect. The path effect value of intrinsic capacity→ social support→ healthy aging was -0.262, accounting for 54.93% of the mediating effect value. The path effect value of intrinsic capacity → exercise self-efficacy→ healthy aging was -0.214, accounting for 44.86% of the mediating effect value. Conclusions:In the community elderly population, social support and exercise self-efficacy can play a mediating role between intrinsic capacity and healthy aging. Community health care providers should pay attention to the internal capacity of the older adults, improve social support and exercise self-efficacy, and thus promote the realization of healthy aging of the older adults.

Objective:To evaluate the diagnostic accuracy and clinical applicability of the Simple Five item Scoring Scale for Sarcopenia (SARC-F) by systematic review and Meta-analysis.Methods:PubMed, The Cochrane Library, Wed of science, EMBASE, MEDLINE, Ovid, China HowNet database, China biomedical data, VIP database and Wanfang database were searched by computer, and all the researches related to SARC-F questionnaire's diagnosis of sarcopenia from the establishment of the database to March 1, 2020 were collected. Two researchers independently selected literature, extracted data, and evaluated the bias risk of the study. Revman 5.3 software, Stata16.0software were used to comprehensively evaluate the diagnostic value of SARC-F questionnaire for sarcopenia.Results:A total of 13 studies involving 8 860 patients were included. The results of meta-analysis showed that the sensitivity and specificity of the diagnostic criteria established by the European Working Group of Sarcopenia, the Asian Working Group for Sarcopenia and the International Working Group for Sarcopenia were used as the gold standard. The area under the receiver operating characteristic curve was 0.71, 0.69 and 0.67 respectively, and the Q-index was 0.659 3, 0.650 9 and 0.631 6.Conclusion:SARC-F questionnaire has a certain value in the screening and diagnosis of sarcopenia. In the future research, it is suggested to add the simple measurement of muscle quality on the basis of this scale to improve the accuracy of the questionnaire screening

Objective:To investigate the effect of early integrated Chinese and western medicine cluster intervention strategy on the prevention of intensive care unit acquired weakness(ICUAW).Methods:A total of 70 patients admitted to the ICU were divided into the intervention group and the control group by random digits table method with 35 cases each. The control group was given limb pressure treatment and limb rehabilitation exercise according to ICU nursing routine, and the intervention group was given early integrated Chinese and western medicine cluster intervention based on the control group, after intervention, the incidence of ICUAW, muscle strength, Barthel index score, mechanical ventilation time, length of stay in ICU and total length of stay between the two groups were compared.Results:The Medical Research Council score of the intervention group and control group were respectively (53.23±5.94) and (43.94±12.58), the Barthel index score were (79.57±7.80) and (66.14±19.25), the incidence of ICUAW were 17%(6/35) and 46%(16/35), the mechanical ventilation time were (162.26±72.27) and (254.06±126.22) h, the length of stay in ICU were (12.20±4.98) and (15.57±6.04) d, the total length of stay were (18.83±6.76) and (23.09±7.88) d, and the differences were statistically significant ( t values were -3.82-3.69, χ2 value was 6.63, P<0.05 or 0.01) . Conclusions:Early integrated Chinese and western medicine cluster intervention strategycan reduce the incidence of ICUAW, improve the muscle strength and daily life activities of patients, shorten the mechanical ventilation time, ICU length of stay and total length of stay in critically ill patients.