Giant condyloma acuminatum (also known as Buschke-Lowenstein tumor) is a rare disease, for which the treatment of choice is still controversial. In the case described in this report, we used a combination of electrocautery and a surgical scalpel to resect a huge genital wart, followed by long-term local treatment with podophyllin. This procedure was relatively fast, easy to perform, involved minimal bleeding, and did not result in any complications. Moreover, combination therapy enabled us to avoid deep resection of the lesion and consequently, sexual function was preserved completely.
Buschke-Lowenstein Tumor* ; Condylomata Acuminata ; Electrocoagulation* ; Hemorrhage ; Podophyllin* ; Rare Diseases ; Warts

Anus Neoplasms ; diagnosis ; etiology ; surgery ; Buschke-Lowenstein Tumor ; Carcinoma, Verrucous ; diagnosis ; etiology ; surgery ; Condylomata Acuminata ; etiology ; pathology ; surgery ; Human papillomavirus 16 ; Human papillomavirus 18 ; Humans ; Male ; Middle Aged ; Papillomavirus Infections ; complications ; Penile Neoplasms ; etiology ; pathology ; surgery ; Time Factors

Verrucous carcinoma is a slowly-growing, well-differentiated, low grade squamous cell carcinoma with little tendency to metastasize. There have been several case reports of this tumor but its occurrence at a young age is extremely rare. Herein we report a case of verrucous carcinoma arising on the anogenitalia of a young woman with pancytopenia.
Buschke-Lowenstein Tumor ; Carcinoma, Squamous Cell ; Carcinoma, Verrucous* ; Female ; Humans ; Pancytopenia

Buschke-Lowenstein tumor is a rare disease in the category of designated as verrucous carcinoma characterized by its invasive downward penetration of underlying tissues in the perineum and perianal regions. Viruses, unclean sanitation and cytotoxic immune reaction have been proposed as the etiology of the tumor. However, among all the causes, recent studies have emphasized on the associaton of the tumor and human papilloma virus (HPV). Expecially, HPV also has been discovered in several cutaneous and anogenital lesions of solid organ transplant recipients. We herein report a case of Buschke-Lowenstein tumor in a renal transplant recipient with HPV 6 and 16 coinfection proved by HPV genotyping of DNA extracted from the biopsy specimen of the tumor.
Biopsy ; Buschke-Lowenstein Tumor* ; Carcinoma, Verrucous ; Coinfection ; DNA ; Human papillomavirus 6 ; Humans ; Papilloma ; Perineum ; Rare Diseases ; Sanitation ; Transplantation* ; Transplants

Buschke-Lowenstein (B-L) tumor occurs in penis associated with human papillomavirus (HPV). It appears as a exophytic cauliflower-like mass that may be foul smelling and sometimes ulcerated. B-L tumor is predominantly associated with HPV 6, 11 and rarely 16, 18. Because HPV 6, 11 are usually isolated from benign lesions, it has been hypothesized that other cofactors such as immunosuppression, poor hygiene, lack of circumcision, and chronic irritation may be involved. In addition, genomic alternation or subtle amino-acid changes in the HPV 6 E7 protein may play a role in enhancing oncogenic properties of the low-risk virus, HPV 6. We present a case of B-L tumor with squamous cell carcinoma that showed HPV 6 positive and altered p53.
Buschke-Lowenstein Tumor* ; Carcinoma, Squamous Cell* ; Circumcision, Male ; Female ; Human papillomavirus 6 ; Humans ; Hygiene ; Immunosuppression ; Male ; Penis ; Smell ; Ulcer