Objective To explore the correlation between serum iron levels and granulomatous lobular mastitis(GLM).Methods A total of 102 patients with GLM were admitted from May 2022 to May 2023.According to the disease course stage at the time of the patients' visit,they were divided into the mass stage group(29 cases),the abscess stage group(48 cases),and the remission stage group(25 cases).Compare the serum iron levels of patients with GLM at different stages.Spearman correlation analysis was used to analyze the correlation between serum iron levels and inflammatory indicators,and the changes in serum iron levels of patients before and after treatment remission were compared through follow-up.Results All the 102 GLM patients were female.The serum iron levels of patients in the abscess stage group,the mass stage group and the remission stage group were 12.8(10.20,17.50)μmol/L,12.8(10.20,17.50)μmol/L and 15.4(13.65,18.50)μmol/L,respectively.The abscess stage group was lower than the mass stage group and the remission stage group,and the difference was statistically significant(P＜0.001).The results of bivariate Spearman correlation analysis showed that the serum iron levels were moderately negatively correlated with white blood cell count,neutrophil count and the percentage of neutrophils(r=-0.336,P=0.001;r=-0.361,P=0.001;r=-0.334,P＜0.01),low intensity negative correlation with monocyte count(r=-0.214,P=0.031),moderately positively correlated with the percentage of lymphocytes,the levels of interleukin(IL)-2,IL-4,IL-10(r=0.328,P＜0.01;r=0.494,P=0.023;r=0.514,P=0.017;r=0.478,P=0.028).Serum iron levels in 45 GLM follow-up patients after treatment remission were higher than those before remission[(15.09±4.78)μmol/L vs.(10.64±4.47)μmol/L,P＜0.001].Conclusion Serum iron level is associated with disease severity,inflammatory markers such as immune cells and cytokines,and disease outcome of GLM.

Objective To explore the correlation between serum iron levels and granulomatous lobular mastitis(GLM).Methods A total of 102 patients with GLM were admitted from May 2022 to May 2023.According to the disease course stage at the time of the patients' visit,they were divided into the mass stage group(29 cases),the abscess stage group(48 cases),and the remission stage group(25 cases).Compare the serum iron levels of patients with GLM at different stages.Spearman correlation analysis was used to analyze the correlation between serum iron levels and inflammatory indicators,and the changes in serum iron levels of patients before and after treatment remission were compared through follow-up.Results All the 102 GLM patients were female.The serum iron levels of patients in the abscess stage group,the mass stage group and the remission stage group were 12.8(10.20,17.50)μmol/L,12.8(10.20,17.50)μmol/L and 15.4(13.65,18.50)μmol/L,respectively.The abscess stage group was lower than the mass stage group and the remission stage group,and the difference was statistically significant(P＜0.001).The results of bivariate Spearman correlation analysis showed that the serum iron levels were moderately negatively correlated with white blood cell count,neutrophil count and the percentage of neutrophils(r=-0.336,P=0.001;r=-0.361,P=0.001;r=-0.334,P＜0.01),low intensity negative correlation with monocyte count(r=-0.214,P=0.031),moderately positively correlated with the percentage of lymphocytes,the levels of interleukin(IL)-2,IL-4,IL-10(r=0.328,P＜0.01;r=0.494,P=0.023;r=0.514,P=0.017;r=0.478,P=0.028).Serum iron levels in 45 GLM follow-up patients after treatment remission were higher than those before remission[(15.09±4.78)μmol/L vs.(10.64±4.47)μmol/L,P＜0.001].Conclusion Serum iron level is associated with disease severity,inflammatory markers such as immune cells and cytokines,and disease outcome of GLM.

Objective To understand and assess the quality status of national drug sampling inspection in 2022 and the possible risks of drug quality.Methods With the aim of identifying issues and preventing risks,a sampling model of"dispersed sampling,centralized inspection,exploratory research,and comprehensive evaluation"was used to review the historical inspection data of national drug sampling.The overall quality and potential risks of national drug sampling in 2022 were analyzed,with a focus on identifying and examining the main quality problems and risks.Results The average pass rate of the sampling inspection in 2022 was 99.4% .The overall safety situation of China's post-marketing drug quality is stable and manageable,indicating that the drug quality is at a high level.Conclusions By carrying out exploratory studies related to drug safety,authenticity,and efficacy,national sampling plays an important role in comprehensively evaluating the quality status of drugs.It aids in improving the quality control level of drug varieties and industry standards,strengthening quality and safety supervision,combating illegal practices such as adulteration and falsification,and providing public warnings about drug safety.

Objective: This study aims to determine the prevalence of overweight and obesity and associated early life factors among children aged 2 to 6 years in a community in Guangzhou. Methods: A stratified cluster sampling was used to select 922 children from one community in Guangzhou in 2018. The survey included a questionnaire survey and physical examination. Logistic regression analyses were performed to examine the relationship of early-life factors and obesity. Results: The prevalence of overweight and obesity was 13.4% in 922 children(16.1% in boys and 10.1% in girls). The sex difference in prevalence of overweight and obesity was statistically significant(Z=2.69, P<0.05). Overweight and obesity was found significantly higher in children with large for gestational age, caesarean section, artificial feeding within 6 months, maternal pre-pregnancy overweight and obesity, maternal excessive weight gain(P<0.01). Large for gestational age (OR=2.62, 95%CI=1.42-4.82), caesarean section(OR=1.59, 95%CI=1.08-2.36), artificial feeding within 6 months(OR=2.00, 95%CI=1.19-3.37), maternal pre-pregnancy overweight or obesity(OR=1.97, 95%CI=1.08-3.58), and excessive gestational weight gain (OR=2.07, 95%CI=1.26-3.39) was positively associated with childhood overweight obesity(P<0.05). Maternal pre-pregnancy underweight was negatively associated with childhood overweight obesity(OR=0.51, 95%CI=0.29-0.88, P<0.05). Conclusion Early-life risk factors are positively associated with the risk of overweight and obesity in later childhood, including large gestational age, caesarean section, artificial feeding within 6 months, maternal pre-pregnancy overweight and excessive gestational weight gain, while maternal pre-pregnancy underweight associates with low risk of child overweight and obesity. These findings suggest that early intervention to these modifiable risk factors could make a significant contribution to childhood obesity prevention.

Objective To compare the changes of BNP and IL-1βin patients with chronic heart failure combined with chro-nic periodontitis before and after periodontal intervention treatment and investigate the improve effect of periodontal intervention treat-ment on the prognosis of chronic heart failure.Methods 38 patients with chronic heart failure combined with chronic periodontitis were divided into the intervention group (n=20) and the control group (n=18).The intervention group was given periodontal inter-vention and the control group was only given oral hygiene education .The baseline and changes of bleeding index , periodontal attach-ment loss and BNP, IL-1βof the two groups were recorded respectively.Results After periodontal treatment, the bleeding index, periodontal attachment loss and the baseline in the intervention group were significantly differenct compared with the control group (p<0.05).The changes of BNP and IL-1βindex in the intervention group were also significantly different from those of the control group (p<0.05).Conclusion The oral hygiene and periodontal health status of the patients could be improved by periodontal inter-vention.It can also improve the prognosis of patients with periodontitis combined with chronic heart failure .In conclusion, the perio-dontal intervention treatment plays a positive role in the treatment of chronic heart failure disease .

ObjectiveTo explore the convenient and effective therapeutic methods for acute lumbar strain on the basis of classification and mechanism of acute lumbar strain.MethodsAcute lumbar strain was classified into post-lumbar joint disturbance type, post-lumbar joint embedded type, muscular strangulated type, muscular strain, sacroiliac joint malposition and mixed type.The repulsion reposition, orthodromic allocation, repulsion ilium and moving leg combioned with high electric frequence were chosen according to the patients' age and somatic condition.ResultsAfter 1-3 times curing, the symptom and appearance of the patients were obviously improved, even more recovery. In these 100 cases,52 patients were cured,39 patients were obviously improved, 9 patients were better than before, the rate of obvious effect was 91%.ConclusionsManipulation combined with high electrical frequence is a convenient, safe and effective method for acute lumbar strain.