Objective:To evaluate the prognostic value of lymph node ratio (LNR) combined with alpha-fetoprotein (AFP), carbohydrate antigen 199 (CA199) and carbohydrate antigen 724 (CA724) in patients undergoing surgical treatment for cervical cancer.Methods:A total of 118 patients with cervical cancer were treated in Yiwu Central Hospital from Jan.2018 to Aug. 2021. Patients with recurrence, metastasis and death during follow-up were included in the poor prognosis group, and vice versa in the good prognosis group. Clinical data, laboratory indicators and LNR, AFP, CA199 and CA724 levels of the subjects were collected. Lasso-Logistic regression analysis was used to screen independent risk factors affecting postoperative poor prognosis of the study subjects, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of LNR combined with AFP, CA199 and CA724 in evaluating postoperative poor prognosis of patients.Results:During the follow-up period, 15 out of 118 patients were lost to follow-up (12.71%, 15/118). Among the remaining 103 patients, 28 patients died, 12 patients had metastasis, and 7 patients had relapse, and the prognosis was 45.63% (47/103). Compared with the good prognosis group, the poor prognosis group had higher clinical stage (stage III), tumor size (> 4.0 cm), differentiation degree (low differentiation), proportion of lymph node metastasis and LNR, AFP, CA199, CA724 levels ( P<0.05). Clinical stage (stage III), differentiation degree (low differentiation), LNR, AFP, CA199, CA724 were independent risk factors for poor prognosis of patients with cervical cancer after surgery ( P<0.05). ROC curve results showed that the area under ROC curve (AUC), 95% CI and specificity of LNR combined with AFP, CA199 and CA724 in evaluating postoperative poor prognosis of cervical cancer patients were 0.904, 0.840-0.969 and 94.60%, respectively, higher than the prediction value of the above indexes alone ( P<0.001) . Conclusion:Abnormal levels of LNR, AFP, CA199 and CA724 are independent risk factors for postoperative poor prognosis in patients with cervical cancer, and the combined detection of these indicators has a higher value in predicting postoperative poor prognosis in patients with cervical cancer.

Objective:To evaluate the prognostic value of lymph node ratio (LNR) combined with alpha-fetoprotein (AFP), carbohydrate antigen 199 (CA199) and carbohydrate antigen 724 (CA724) in patients undergoing surgical treatment for cervical cancer.Methods:A total of 118 patients with cervical cancer were treated in Yiwu Central Hospital from Jan.2018 to Aug. 2021. Patients with recurrence, metastasis and death during follow-up were included in the poor prognosis group, and vice versa in the good prognosis group. Clinical data, laboratory indicators and LNR, AFP, CA199 and CA724 levels of the subjects were collected. Lasso-Logistic regression analysis was used to screen independent risk factors affecting postoperative poor prognosis of the study subjects, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of LNR combined with AFP, CA199 and CA724 in evaluating postoperative poor prognosis of patients.Results:During the follow-up period, 15 out of 118 patients were lost to follow-up (12.71%, 15/118). Among the remaining 103 patients, 28 patients died, 12 patients had metastasis, and 7 patients had relapse, and the prognosis was 45.63% (47/103). Compared with the good prognosis group, the poor prognosis group had higher clinical stage (stage III), tumor size (> 4.0 cm), differentiation degree (low differentiation), proportion of lymph node metastasis and LNR, AFP, CA199, CA724 levels ( P<0.05). Clinical stage (stage III), differentiation degree (low differentiation), LNR, AFP, CA199, CA724 were independent risk factors for poor prognosis of patients with cervical cancer after surgery ( P<0.05). ROC curve results showed that the area under ROC curve (AUC), 95% CI and specificity of LNR combined with AFP, CA199 and CA724 in evaluating postoperative poor prognosis of cervical cancer patients were 0.904, 0.840-0.969 and 94.60%, respectively, higher than the prediction value of the above indexes alone ( P<0.001) . Conclusion:Abnormal levels of LNR, AFP, CA199 and CA724 are independent risk factors for postoperative poor prognosis in patients with cervical cancer, and the combined detection of these indicators has a higher value in predicting postoperative poor prognosis in patients with cervical cancer.

Betacoronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Single-Cell Analysis

Objective To evaluate the safety and effect of embryo aspiration and fetal cardiac activity area injection of transvaginal pregnancy multi -fetal reduction for women with early pregnancy.Methods Retrospective a-nalysis of 120 cases with transvaginal early pregnancy multi -fetal reduction was conducted.The pregnancy outcome of the two ways was analyzed and evaluated.Results Among 120 cases,55 cases were treated with fetal cardiac activity area injection,65 cases were treated with embryo aspiration.Fetal cardiac activity area injection group:gestational age (48.7 ±9.1)d,postoperative infection abortion rate:12.7% (7 cases),rate of premature babies:5.5% (3 cases). Embryo aspiration group:gestational age (46.9 ±4.2)d,postoperative infection abortion rate:6.2% (4 cases),rate of premature babies:3.1% (2 cases),the difference between postoperative infection abortion rate was statistically sig-nificant (P =0.02).Virgiria Apgar score (P =0.41),neonatal weight(P =0.70),fetal malformation rate (P =0.24),neonatal move to NICU rate (P =0.83),the differences were not statistically significant.Conclusion During the early stage embryo aspiration is a safe method for the multi -fetus reduction,the pregnancy outcome is better than fetal cardiac activity area injection.