Perineurioma (PN) is an uncommon benign tumor originating from the peripheral nerve sheath and composed solely of perineurial cells. Most PNs occur sporadically and are typically described as painless masses. This report presents an atypical case of extraneural or soft tissue PN (ESTP) in a 37-year-old Filipino female with a history of trauma. The patient presented with a 5-month history of a gradually enlarging nodule on her right thumb accompanied by localized dull pain. Physical examination revealed the presence of an ill-defined, slightly erythematous, firm, movable, and tender nodule. Histopathological analysis demonstrated characteristic features of ESTP, including spindled cells arranged in a whorled pattern. Immunohistochemical staining for epithelial membrane antigen was positive, while S-100 staining was negative, which confirmed the diagnosis. The nodule was successfully excised without any complication. There was no recurrence observed during the 4thmonth postexcision. This case highlights the importance of considering ESTP as a potential diagnosis for painful masses following trauma and suggests a possible association between ESTP and trauma. Surgical excision remains the preferred treatment option for ESTP, and recurrences are infrequent.

Human ; Female ; Adult: 25-44 Yrs Old ; Nerve Sheath Neoplasms

INTRODUCTION: Administration of parenteral medications may cause pain in infants. This study aimed to assess the efficacy of a nursery rhyme in increasing the comfort of infants after vaccination. METHODS: Infants who were brought to six barangay health centers for vaccination were recruited. Infants from three barangay health centers were randomly assigned to the experimental group, while infants from the other three were assigned to the control group. A Filipino nursery rhyme Tatlong Bibe was played to the experimental group. The comfort of each infant was then assessed by a pediatrician prior to, immediately after, and two minutes post-vaccination using the COMFORTB scale. Results were analyzed using independent t-tests. RESULTS: Prior to vaccination, the control and experimental groups had mean COMFORT-B scores of 12.46 and 12.74 (p = 0.634), respectively. The immediate post-vaccination mean COMFORT-B scores were 22.14 and 21.63 (p = 0.420), while the 2 minutes post-vaccination mean COMFORT-B scores were 16.40 and 16.49 (p = 0.927), respectively. There were no significant differences between groups for the three determinations. CONCLUSION Based on the study results, the nursery rhyme had no significant effect on the comfort of infants after vaccination.