Background: Nicotine-containing vaporized liquids—composed of propylene glycol, glycerin, water, flavorings, and the thickening agent vitamin E acetate—have been implicated in the development of EVALI. Under conditions of low liquid levels and overheating, these substances release toxic carbonyl compounds (e.g., formaldehyde, acetaldehyde, acrolein). In a 2019 national survey, 3.5% of adolescents aged 13–15 reported cigarette use, and 10% used e-cigarettes. Aim: To study the changes in the behavior, lung, and hippocampal structures of rats due to the effects of electronic cigarettes and their vapor. Materials and Methods: In this study, nineteen 14-day-old SHR rats were exposed to 1 g/mg/day of nicotine and dry hit vapor (control, nicotine and dry hit groups) for four weeks. Behavioral assessments (Open Field Test, Elevated Plus Maze, Conditioned Place Preference), bronchoalveolar lavage (BAL), and histological analysis of lung and hippocampal tissue were conducted. Results: The dry hit vapor group showed significantly reduced body weight (p=0.034), increased anxiety (p=0.006, p=0.025), and avoidance of the smoky chamber. BAL revealed elevated total cells, neutrophils, and macrophages (p=0.01, p=0.04) in both nicotine and dry hit groups. Lung tissue exhibited alveolar septal thickening, inflammation, and emphysema- like changes. Extensive neuronal death was observed in the hippocampus. Conclusion Anxiety-like behavior was observed in both the burn and control groups. Analysis of BAL in the dry hit group revealed inflammation predominantly characterized by macrophage infiltration. Histological examination of lung tissue from both experimental groups demonstrated a reduction in the number of alveoli, accompanied by acute inflammation and thickening of the interalveolar septa. In the hippocampal region, neuronal loss and a reduction in neuronal density were also observed.

The study is devoted to the morphological characteristics of the maturation of lung tissue structures in the fetal period. Fetal histology of the lungs presents the intrauterine development of lung tissue in four successive stages: pseudoglandular, canalicular, saccular and alveolar, each has specific morphological criteria. The following morphological features are predetermined: the development of alveolar epithelium, the ratio of mesenchyme towards the area in alveolar spaces, the degree of proliferation and location of vessels of the microcirculatory bed towards prealveolar partitions. During the fetal period the alveolar columnar epithelium is flattened and differentiates into alveolocytes type I lung histology with the demonstration of histological preparations of the lungs at different stages of intrauterine development. Keywords: fetal lungs, prealveolar structures, pseudoglandular stage, canalicular stage, alveolar stage, alveolar capillary membrane, immunohistochemical study. 16 and II, the area of the mesenchyme gradually decreases and by the birth of a full-term newborn kid it is present mainly in the thickness between the alveolar septa, microcirculation vessels, initially laying deep in the thickness of the mesenchymal tissue, gradually proliferate, approach the pre-alveolar epithelium, channeling it with the formation of alveolar capillary membranes. Air exchange in the lung tissue is mainly provided with two factors: the presence of second-order alveolocytes capable of producing surfactant, and a sufficient formation of alveolias well. This work summarizes the basics of fetal lung histology with the demonstration of histological preparations of the lungs at different stages of intrauterine development.

Abstract Epilepsy, a neurological disorder characterized by recurrent seizures, affects millions of people worldwide. Significant advancements in both diagnostic and therapeutic approaches have greatly improved outcomes, particularly for individuals with drug-resistant epilepsy. Modern neurostimulation techniques such as Responsive Neurostimulation (RNS), Deep Brain Stimulation (DBS), and Vagus Nerve Stimulation (VNS) have demonstrated effectiveness in reducing seizure frequency in these patients. Additionally, emerging technologies like gene therapy and optogenetics are being explored to better understand the underlying mechanisms of epilepsy and hold promise as future treatment modalities.Traditional imaging techniques often fail to detect subtle epileptogenic zones. However, the introduction of ultra high-field 7T MRI scanners represents a major breakthrough. These advanced scanners use eight transmitters to generate higher-resolution images, reducing signal dropout and enabling the identification of previously undetected lesions. In one study involving 31 patients, 58% had their treatment plans modified based on 7T MRI findings, highlighting its potential to inform surgical decision-making. In terms of pharmacological treatment, newer medications such as sultiame, cannabidiol (CBD), and non-pharmacological approaches like the ketogenic diet have emerged as additional therapeutic options for drug-resistant epilepsy. These developments contribute to more effective, personalized management strategies for epilepsy. In summary, the landscape of epilepsy diagnosis and treatment is rapidly evolving. Innovations in imaging and therapeutic interventions are offering new hope for patients with drug-resistant epilepsy. Ongoing research and clinical trials remain essential to further refine these approaches and improve patient outcomes.

: We report a case of a 1-day-old neonate presenting with classic clinical and radiologic features of sacral agenesis, a rare congenital disorder. Early identification and multidisciplinary management are critical to improving outcomes. Case Presentation : A full-term, 1-day-old infant was examined for multiple congenital deformities. Physical f indings included a large head, round eyes, and a shallow chest. The lower limbs were short, internally rotated, and stiff, with minimal mobility at the hip and knee joints. External rotation of the hips was not possible, and both feet were turned inward.
A CT scan of the lumbar spine (without contrast) revealed normal cervical and thoracic vertebrae. However, one thoracic vertebra showed an unclear structure. At the spine’s end, a 2.0 × 1.5 × 1.1 cm spindle shaped mass with a density of +14 to +27 HU was seen under the skin on the right. The pelvis appeared underdeveloped, with an incomplete oblique fracture of the upper right midshaft femur. Upright radiography confirmed underdeveloped pelvic bones. The medial malleolus and tibia appeared symmetrical bilaterally. Epidemiology: Sacral agenesis (caudal regression syndrome) is a rare congenital condition with an estimated incidence of 1 in 100,000 live births. It is more common in infants born to mothers with pregestational diabetes, although it can occur sporadically. Both genetic and environmental factors may contribute.[11] Discussion : Sacral agenesis results from abnormal development of the caudal mesoderm during early embryogenesis, leading to partial or complete absence of the sacrum and sometimes lumbar spine. The severity ranges from isolated sacral agenesis to complete lumbosacral agenesis with associated genitourinary, gastrointestinal, and limb deformities. [8-10].
The current case presented with classic signs: bilateral lower limb deformities, limited joint mobility, underdeveloped pelvis, and a spinal abnormality. The presence of a spindle-shaped subcutaneous mass may represent a lipoma or associated spinal dysraphism. The incomplete femoral fracture may be due to birth trauma in the context of fragile bones or abnormal limb positioning.
Early imaging helps confirm the diagnosis and evaluate associated anomalies. Management typically involves orthopedic, neurologic, and urologic interventions. Long-term care focuses on mobility, continence, and developmental support. [13,14]. Conclusion: This case emphasizes the importance of recognizing sacral agenesis at birth through clinical examination and radiological imaging. Although rare, early diagnosis is vital for implementing supportive care and planning multidisciplinary interventions. Close follow-up is essential to monitor motor development and prevent complications. Ethical Considerations (EHT) : Ethical approval was obtained from the institutional review board. Parental consent was secured for the publication of clinical data and images. All procedures followed ethical standards of clinical care and the Helsinki Declaration. Confidentiality of patient information has been maintained throughout the report. No invasive procedures beyond standard diagnostics were performed. Acknowledgments The authors thank the Neonatology and Radiology Departments of Regional Diagnostic Center of Umnugovi Province for their contributions to the diagnosis and imaging. We also appreciate the cooperation of the child’s family and the medical ethics committee for guidance and approval. Special acknowledgment to the Division of Pediatric Neonatologists for their early intervention planning and support.

Introduction: Scutellaria baicalensis Georgi, which is used in traditional medicine, has the ability to remove blood-drying heat. Chiazospermum erectum Bernh. has the ability to relieve typhoid fever and poison fever. Carthamus tinctorius L. has antiseptic, analgesic and anti-toxic properties. Saussurea amara L. has bactericidal, anti-infective, and anti-inflammatory properties. Researchers found that the Hepaclin-4 recipe has antioxidant, membrane-strengthening, liver-protective, necrosis-preventing, detoxification, and peroxidation product accumulation-reducing properties. Therefore, extracting the granular medicine form from the concentrated extract containing the Hepaclin-4 formulation is the basis of our research work. Goal: To obtain the granular medicine form from the concentrated extract containing ingredients of the Hepaclin-4 recipe. Materials and Methods: The research was carried out with the support of the Institute of Pharmaceutical Research and the University of Pharmaceutical Sciences. The raw materials for the Hepaclin-4 formula were extracted by remaceration with water, 40% ethanol, and 70% ethanol (1:10 ratio). Six types of granules were extracted from the concentrated extract using several excipients by the wet granulation method, and the pouring weight and flowability were determined. Results: The quality index of the concentrated extract of the Hepaclin-4 recipe complies with the standards outlined in the 11th Pharmacopoeia of the National Pharmacopoeia of Mongolia. In qualitative analysis of total flavonoid, spots were detected at the same level as standard quercetin (Rf=0.88) and rutin (Rf=0.4), indicating the presence of flavonoids. According to the results of the above research, lactose was found to be the suitable filler for extracting granules, and starch at 8% was identified as the appropriate binding agent from the concentrated extract of the Hepaclin-4 formula. Conclusion It was found suitable to select 8% lactose as a filler and starch as a binding agent from the concentrated extract of the Hepaclin-4 formula and obtain a granule drug form using the wet granulation method.

Introduction Gastric ulcer is one of the most common disorders considering the gastrointestinal tract, it affects 5% of the population around the world, so its prevention and management are considered very important challenges. Researchers have revealed several causes of gastric ulcer; these include an imbalance between aggressive and intrinsic defensive factors. Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. The aggressive factors include non-steroidal anti- inflammatory drugs(NSAID),alcohol, psychological stress and Helicobacter pylori infection, cytoprotective intrinsic factors include mucosal blood flow, bicarbonate, mucus, cell renewal, growth factors, NO and prostaglandins, NSAID-induced gastric damage is known to be the most common and dangerous side-effect of these drugs and accounts for 25% of gastric ulcer cases.
Indomethacin (INDO) is considered to be the most common NSAID known to induce experimental gastric ulcer and has been documented to have a higher potential to cause gastric injury than other commonly used NSAIDs.
Most of the drugs which are used for wound healing are imported in Mongolia. It is required to develop drug formulation and increase local productions used for the treatment of wound healing. For the purpose of solving the above problems, we aimed to prepare new drug formulation from Cacalia hastata L. for the treatment. of wound healing. Cacalia hastata L. is a medicinal plant, member of the family Asteraceae. Cacalia hastata L. is widely used for the Mongolian traditional medicine to treat wound healing, gastric ulcer, poisoning fever, liver fever, bile fever, oral cavity, and gynecological diseases

Introduction: Antimicrobial Resistance (AMR) has emerged as a significant public health and economic issue worldwide, affecting both developed and developing countries. Our research has been motivated by the increasing prevalence of carbapenem-resistant P. aeruginosa, A.baumannii, and K. pneumonia in recent years. Goal: To determine antibiotic susceptibility of the pathogens isolated from wound infection and to detect its multidrug resistance. Material and Method: Samples were collected from patients with wound infections. Pathogens were identified by using the traditional culture methods and the API system with serotypes determined phenotypically. Antibiotic susceptibility was assessed using the disk diffusion method and the MIC to analyse antibiotic resistance. Results: In the study, among 11,221 recorded cases of wound infections in 2023, bacterial pathogens were detected and identified at the species level in 10,339 cases (92.1%).
For identification results showed that A. baummannii were detected from 138 cases (1.3%), 216 cases (2.08%) of Ps. aeruginosa, 5 cases (0.04%) of B. cepacia, 1,383 cases (13.4%) of Enterobacteriaceae, 205 cases (2.0%) of Enterococcus spp., 8,329 cases (80.5%) of Staphylococcus spp., and 63 cases (0.6%) of Streptococcus spp.
Antibiotic susceptibility of these bacteria was assessed and determined multidrug resistance. We found the followings: For A. baumannii were resistant with MDR in 68 cases (49.3%), MRSA in 4,243 cases (51.1%), MDRSta. aureus in 1,805 cases (29.4%), VRE in 34 cases (16.5%), ESBL in 4.6%, KPC in 26 cases (11.1%), FRNF in 24 cases (11.6%), and CRPA in 13 cases (6.3%). Conclusion
1. Of all wound infections reported in 2023 in 92.1% there were detected pathogenic bacteria, of which S.aureus were in 80.5% and E. coli was in 13.4%
2. 60.7% of the pathogenic bacteria detected in wound infections were multidrug-resistant, with MRSA accounting for 51.1% and MDR A.baumannii accounting for 49.3%, indicating high antimicrobial resistance(AMR).

Introduction: Pharmacist and customer satisfaction is unique to other industries because it has a significant impact on patient outcomes and the quality of primary health care. In the framework of health sector reforms, improving the ethics and attitudes of medical professionals, the quality of care, internal environment and safety has become a priority issue for the development of the organization.
According to statistical data, in 2020, there are 2343 second-class pharmacies in Mongolia, 1254 in Ulaanbaatar, and 1249 pharmacies in Ulaanbaatar in 2021. As of 2020, there are 2639 pharmacists and 2009 drug directors working in the country, and in 2021, there are 2913 pharmacists and 2010 drug directors. Compared to the previous year, the number of pharmacists has increased by 0.8%, and the number of drug directors has increased by 13% has indicators. According to the above statistics, it is appropriate to study the satisfaction of specialists and clients in line with the increasing number of pharmacies and specialists.
As of the 1st quarter of 2023, pharmaceutical experts who play an important role in the quality and availability of pharmacy services and social economic development in the world (Pakistan, America, Canada. Great Britain, Spain, South Africa, etc.) Because it is important to study the satisfaction of pharmacists and the satisfaction of pharmacy users, we are conducting regular satisfaction surveys. Purpose and objectives: The purpose of the research is to evaluate the satisfaction of customers and pharmacists in the pharmacy of Ulaanbaatar. For this purpose, the following objectives were proposed. It includes:
1. Survey of pharmaceutical experts and pharmacy users determine the sample size
2. To evaluate the satisfaction of pharmacy users through a questionnaire
3. To evaluate the satisfaction of pharmacists by questionnaire
4. Compare the level of satisfaction by age group and perform statistical processing Materials and methods: A survey of pharmacy customers and pharmacist satisfaction was conducted using a Cross-sectional studies model. The Survey system calculator was used to calculate the sample size based on the representativeness of the sample to be studied. The survey was conducted between the 4th quarter of 2022 and the 2nd quarter of 2023. and the satisfaction of customers and pharmacists was obtained by random sampling by the UB City Hospitals and Health Deparments, and data was collected using 2 types of questionnaires to be evaluated on a 5-point Likert scale using the SERVQUAL model. The results were processed using Microsoft Excel and SPSS 23.0 software. The reliability of the survey questionnaire was calculated using the Cronbach alpha coefficient. Results: A total of 758 people participated in our study, and satisfaction was determined by including n=369 pharmacists and n=389 customers, respectively. A breakdown of the results:
369 pharmacists participated in the survey, and according to the total number of questions, 48.0% n=177 are satisfied, 37.7% n=139 are very satisfied. Considering the satisfied age group of pharmaceutical specialists, n=101 specialists in the age group of 26-35 years are the most satisfied.
52.85% n=195 satisfied. 25.20% n=93 Very satisfied, 20.87% n=77 Moderately satisfied, 0.54% n=2 Not at all satisfied, 0.54% n=2 He replied that he did not know. According to the results of the survey, pharmaceutical professionals are highly satisfied.
On the other hand, 389 customers participated in the satisfaction survey of pharmacy users, and according to the total results of the group questions, 67.4% n=262 customers were moderately satisfied with the organization's care and service culture and intimate environment outside the organization is satisfied. Looking at the satisfaction of pharmacy customers by age group, n=121 customers under 25 years of age have moderate satisfaction is satisfied.
49.61% n=193 not satisfied at all, 35.22% n=137 Moderately satisfied with the pharmacy services from the surveyed customers, degree, 9.55% n=37 Very satisfied, 5.66% n=22 answered that they do not know. Therefore, it shows the need to consider the quality of care. Conclusion 369 experts were included in the survey to evaluate the satisfaction of customers and pharmacists with the pharmacy, and 2 groups of evaluations were used in the survey. The reliability of the 22 questionnaires, calculated by Cronbach's alpha coefficient, is good between 0.9 a≥0.846. The majority of pharmaceutical professionals (n=316) surveyed are satisfied with their profession and workplace.
However, the reliability of the questionnaire used in the research to evaluate the satisfaction of customers in the pharmacy, when calculated by Cronbach's alpha coefficient, is acceptable between 0,8 a≥0.777. The n=262 customers surveyed are moderately satisfied with pharmacy services.
Depending on the age group of the people involved in the research, the location where they work and serve, the relationship attitude, understanding, and workload satisfaction level are different.

Background: Retinal pathologic features are associated with inflammatory processes and endothelial dysfunction, leading to circulatory abnormalities and reduced vascular reactivity. Both retinopathy and nephropathy involve thickening of basement membrane and muscular layers and increased leakage. These pathologic and hemodynamic abnormalities may occur throughout the body and their effects on the retinal vasculature may be useful indicators of cumulative microvascular damage from hypertension, inflammation, diabetes mellitus, and other processes. Type 2 MPGN is an uncommon renal condition associated with electron dense deposits in the lamina densa of the glomerular basement membrane with C3 found in the capillary loops and mesangium. The deposits in the basement membrane can lead to a breakdown of the blood-retinal barrier by interfering with the RPE layer, and type 2 MPGN has been described in association with central serous retinopathy. Purpose: To assess the retinal findings in end stage of Chronic kidney disease (CKD) and diabetic renal failure Methods: Data of diabetic renal failure (n=20, mean age 56.8±11.6), and end stage of CKD(n=83, mean age 48.2± 11.6) were cross-sectional analyzed. Nonmydriatic fundus photographs of the disc and macula in both eyes were obtained in all the subjects. The photographs were assessed by ophthalmologist using the standard protocols. The following parameters were recorded: BCVA, IOP, BP GFR, serum Creatinine, ophthalmic and fundus examination. Results: Greater severity of retinopathy was associated with DM. The presence of vascular abnormalities usually associated with Diabetes Mellitus ( DM) and was not associated with lower estimated glomerular filtration rate. All of patients with DM (n=20, 100%) ,they have Diabetic retinopathy. We found sight direct relationship between retinal posterior pole deposit with CKD patients. Some of patients who have end stage of CKD, (n=18, 11%) they have retinal deposit on their posterior pole. Conclusion Our findings show ,In participants with end stage of CKD, there was no significant severe retinopathy. In summary, our study demonstrates that DM, is one of the leading cause of irreversible vision loss. Every patients with DM need the ophthalmic follow up examination in every six months.

Description: Asymptomatic bacteriuria is defined as the presence of 1x105 or more bacteria per milliliter of urine, although there are no signs of UTI [1]. Asymptomatic bacteriuria is quite common and occurs in 1-5% of healthy women before menopause. The incidence of asymptomatic bacteriuria increases in the elderly (men and women) to 4-19%. Asymptomatic bacteriuria is observed in 0.7% -27% of patients with diabetes mellitus, in 2-10% of pregnant women and in 23-89% of patients with spinal cord injury. Asymptomatic bacteriuria is rarely observed in young men and always requires differential diagnosis with chronic bacterial prostatitis[2].
Among the elderly, those in institutionalized settings such as long-term care facilities and hospitals have a higher prevalence of asymptomatic bacteriuria than those living in the community. Therefore, interest in asymptomatic bacteriuria has shifted from the general population to these groups of individuals. The prevalence varies from 2% to 10% in pregnancy and from 15% to 50% in the elderly in long-term care facilities.[3,4]
This study was undertaken to determine the prevalence of people asymptomatic bacteriuria in among hospitalized people. Purpose: Investigate cases of asymptomatic bacteriuria among hospitalized individuals and determine antibiotic susceptibility by type of pathogen detected in urine. Materials and methods: This cross-sectional study in the “I” Hospital of UB city, Mongolia. We conducted into the study 133 patients. After obtaining informed consent, a midstream clean-catch urine sample was collected in the same 24 hour time window and was evaluated for urinalysis using a dipstick test and routine culture. A positive urine culture was defined as a single urine sample with microbal growth of >10⁵ colony- forming units of a single organism. We use 5-10% Blood agar, UTI agar, Mackkong agar and Chroma agar for a bacterial growth. Then we did antibiotic susceptibility of the determined pathogen. Result: The average age of the respondents was 55.9±14.6, the youngest was 17 years old and the oldest was 91 years old (CI 95% 53.4-58.5). By age group, 4.5% (n = 6) of people aged 20-30, 21.1% (n = 28) of people aged 31-45, 37.5% (n = 50) of people aged 46-60, and people over 61 years of age 36.8% (n = 49) respectively.Of the respondents, more than 56 or 54.9% (n = 73) were elderly, of which 63.9% (n = 85) were women and 36.1% (n = 48) were men.
A total of 36 (27.1%) leukocytes were detected, and 25 (34.2%) more (P-0.05) were detected in people over 56 years of age. The protein detected in 24 (18.0%) people, all over 56 years of age and more defined in men (P-0.01).
80.5% (n = 107) of those surveyed were diagnosed with the pathogens, and 54.9% were elderly (P-0.031). 82.4% of women and 77.1% of men were diagnosed with urinary pathogens.
Streptococcus 26%, E.coli 19%, Saprophyticus 13%, Enterococcus 11% and Staphylococcus 11% were detected in the analysis, and Streptococcus and E.coli (19%) accounted for a slightly higher rate of infection.
A total of 13 types of pathogens were identified, of which 53.4% were susceptible, 21.7% were moderately sensitive, and 24.9% were non-susceptible. Discussion: According to a study conducted by researchers at the University of Taiwan, the prevalence of asymptomatic UTI-s in the general population is 57.8%. E.Coli was also the most common bacterium in the urine [6].
In our study, there are many cases of E. coli.
Study in the United States found that the prevalence of asymptomatic bacteriuria among inpatients was 8.5%, all of them women. The most common pathogens in this study are Enterococcus bacteria. This study found that 1 in 10 people admitted to the hospital may have asymptomatic bacteriuria. [1] Conclusion
1. Asymptomatic bacteriuria in 80.5% of those surveyed 54.9% were detected in people over 56 years of age.
2. Antibiotic susceptibility of the tested pathogens was determined as 53.4% sensitive, 21.7% moderately sensitive and 24.9% insensitive.