1.Reduced phosphorylated Foxp3 levels in Crimean Congo haemorrhagic fever
Gazi, U. ; Baykam, N. ; Karasartova, D. ; Tosun, O. ; Akdogan, O. ; Yapar, D. ; Sensoz, S. ; Celikbas, A.K. ; Semra-Gureser, A. ; Taylan-Ozkan, A.
Tropical Biomedicine 2022;39(No.4):587-591
Crimean-Congo haemorrhagic fever (CCHF) is a severe human infection which can lead to fatal
consequences. Acute CCHF patients were previously shown to exhibit frequencies of regulatory T-cell
(Treg) but lower Treg-mediated suppressive activities than the healthy counterparts. This study aims
is to investigate the phosphorylation levels of Foxp3 protein (master regulator of Treg cells) in CCHF
patients. Blood samples collected from 18 CCHF patients and nine healthy volunteers were used to
isolate peripheral blood mononuclear cells (PBMCs). Total and phosphorylated Foxp3 expression levels
in the isolated PBMC samples were monitored by western blot and quantified using ImageJ software.
Total Foxp3 expression levels in CCHF patients displayed decreasing trend, but not significantly. In
contrast, significantly lower expression levels of phosphorylated Foxp3 were reported in CCHF patients.
Our results suggest a possible association between Foxp3 dephosphorylation and CCHF pathogenesis.
Nevertheless, more studies are required to evaluate the effect of Foxp3 dephosphorylation on Treg
function, which would not only help to enlighten the CCHF pathogenesis but also contribute to the
development of effective treatment strategies.
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