Abstract Background: Nasopharyngeal cancer (NPC) is a malignancy of the nasopharyngeal mucosal epithelium. Primary and secondary metastases in nasopharyngeal cancer are generally prevalent in the bones. Gene expression plays a critical role in regulating fundamental cellular processes in cancer cells, including metastasis. Methods: A total of 29 patients with non-metastatic NPC were included in the study. Results: The mean age of the participants was 48.45±9.98 years old. Most participants were male (75.9%). More than half of the participants had T4 and N2, 52.7% and 51.0% respectively). Secondary metastasis was observed in 9 of the 29 participants within two years. Patients with secondary metastases had a higher proportion of T4 (7/9) and N2 (4/9) disease. Bone was the first site of secondary metastasis (6/9 patients). The median time to secondary bone metastasis was 14.0 (6.8-21.2) months. Based on the differential expression gene (DEG) analysis, the MMP9 gene was upregulated 12.50 (4.18–37.40), adjusted p <0.01, and the ADNP gene was downregulated 0.141 (0.04–0.43), adjusted p 0.04, among patients with secondary bone metastasis. Conclusion: Bones are the first site of metastasis, with a time to metastasis of 14.0 (6.8-21,2) months. MMP9 was upregulated, and ANDP was downregulated in patients with bone metastasis compared to those without metastasis.
MMP-9 ; ADNP ; nasopharyngeal cancer ; secondary bone metastasis

Multiple traumas require a fast and comprehensive treatment to overcome challenges that emerge from the patient’s condition. The right time for trauma team activation is necessary to treat these multiple trauma patients to improve patient outcomes. This integrative review identifies the criteria used to activate the trauma team, the activation process and the outcome of the activation. The search was conducted from January to March 2023 with two databases, namely MEDLINE and PubMed, and grey literature via Google Scholar. The search was limited to articles written in English, with abstracts and available in full text. There was no year limitation. The review found four criteria that were used for trauma team activation: physiological, anatomical, mechanism of injury and others. The process of trauma team activation begins in the pre-hospital setting. Outcomes used to evaluate the impact of trauma team activation included the level of satisfaction of patients and families, the level of complaints, response time, discharge status, and mortality. The findings of this review recommend that the criteria, process, and outcomes of trauma team activation are tailored, based on the needs and available resources of the institutions. Moreover, standardized trauma team activation may be necessary for future development.