1.PARANEOPLASTIC RHEUMATIC DISORDER IN ACUTE LEUKAEMIA: DIAGNOSTIC CONUNDRUM
Wan Suriana WAN AB RAHMAN ; Wan Majdiah WAN MOHAMAD ; Abu Dzarr GANESH ABDULLAH ; Mohd Nazri HASSAN ; Zefarina ZULKAFLI ; Shafini YUSOF ; Salfarina IBERAHIM ; Noor Haslina MOHD NOOR ; Rosnah BAHAR ; Marini RAMLI ; Marne ABDULLAH
Brunei International Medical Journal 2024;20():19-23
The association of paraneoplastic rheumatic disorder and acute lymphoblastic leukaemia is rarely
reported in the adolescent male. The clinical manifestations develop within two years before the diagnosis of associated malignancy. We report a case of an 18-year-old male, who presented with pyrexia of unknown origin, bicytopenia and autoantibodies that was consistent with the diagnosis of systemic lupus erythematosus. The peripheral blood film was eventually consistent with pancytopenia, devoid of any dysplastic changes or abnormal cells. When his cytopenia persisted despite empirical steroid therapy, a trephine biopsy revealed a diagnosis of acute lymphoblastic leukaemia. He was started on chemotherapy with UKALL regime and was well in his recent follow-up early this year where he was on maintenance therapy.
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