Objective To explore the predictive value of neutrophil to platelet ratio(NPR)in acute renal injury(AKI)in sepsis.Methods Patients with sepsis admitted to the emergency intensive care unit of Xinjiang Uygur Autonomous Region People's Hospital from February 2023 to May 2024 were retrospectively analyzed.According to the guidelines of the Global Organization for Improving the Progno-sis of Nephropathy(KDIGO)in 2012,septic patients were divided into acute renal injury group(AKI group)and non-acute renal injury group(non-AKI group).The basic clinical data on admission,including age,complications,28-day prognosis and the first neutrophil count,platelet count,procalcitonin,lactic acid and NPR within 24hours after admission were recorded and compared between the two groups.The risk factors of septic AKI were screened by Logistic regression analysis,the diagnostic efficacy of NPR in septic AKI was eval-uated by receiver operating characteristic(ROC)curve,and the correlation between NPR and AKI stage of sepsis was analyzed by Spearman.Results Finally,159 patients with sepsis were included,including 87 patients in AKI group and 72 patients in non-AKI group.The incidence of AKI was 54.7％.Compared with non-AKI group,procalcitonin,IL-6,lactic acid,D-dimer,uric acid,NPR,neutrophil to lymphocyte ratio(NLR),neutrophil to lymphocyte and platelet ratio(N/LPR)in septic AKI group were significantly higher than those in septic non-AKI group,while the platelet count and lymphocyte count in sepsis group were significantly lower than those in non-AKI group(P＜0.05).Multivariate Logistic regression analysis showed that the increase of NPR,lactic acid,uric acid and the decrease of lymphocyte count were the independent risk factors of septic AKI.ROC curve analysis showed that NPR had good clinical value in predicting the occurrence of septic AKI.The area under the curve(AUC)was 0.731,which was better than that of NLR,but lower than N/LPR,and the predictive efficacy of N/LPR was also higher than that of the combination of NPR and NLR.Spearman corre-lation analysis showed that there was a positive correlation between NPR,N/LPR and AKI stage in patients with sepsis AKI.Conclusion The increase of admission NPR is an independent risk factor for septic AKI,which has a good predictive value,and high NPR is more closely related to the risk of severe AKI in septic AKI patients.NPR can predict the occurrence of septic AKI to some extent.

Objective To explore the predictive value of neutrophil to platelet ratio(NPR)in acute renal injury(AKI)in sepsis.Methods Patients with sepsis admitted to the emergency intensive care unit of Xinjiang Uygur Autonomous Region People's Hospital from February 2023 to May 2024 were retrospectively analyzed.According to the guidelines of the Global Organization for Improving the Progno-sis of Nephropathy(KDIGO)in 2012,septic patients were divided into acute renal injury group(AKI group)and non-acute renal injury group(non-AKI group).The basic clinical data on admission,including age,complications,28-day prognosis and the first neutrophil count,platelet count,procalcitonin,lactic acid and NPR within 24hours after admission were recorded and compared between the two groups.The risk factors of septic AKI were screened by Logistic regression analysis,the diagnostic efficacy of NPR in septic AKI was eval-uated by receiver operating characteristic(ROC)curve,and the correlation between NPR and AKI stage of sepsis was analyzed by Spearman.Results Finally,159 patients with sepsis were included,including 87 patients in AKI group and 72 patients in non-AKI group.The incidence of AKI was 54.7％.Compared with non-AKI group,procalcitonin,IL-6,lactic acid,D-dimer,uric acid,NPR,neutrophil to lymphocyte ratio(NLR),neutrophil to lymphocyte and platelet ratio(N/LPR)in septic AKI group were significantly higher than those in septic non-AKI group,while the platelet count and lymphocyte count in sepsis group were significantly lower than those in non-AKI group(P＜0.05).Multivariate Logistic regression analysis showed that the increase of NPR,lactic acid,uric acid and the decrease of lymphocyte count were the independent risk factors of septic AKI.ROC curve analysis showed that NPR had good clinical value in predicting the occurrence of septic AKI.The area under the curve(AUC)was 0.731,which was better than that of NLR,but lower than N/LPR,and the predictive efficacy of N/LPR was also higher than that of the combination of NPR and NLR.Spearman corre-lation analysis showed that there was a positive correlation between NPR,N/LPR and AKI stage in patients with sepsis AKI.Conclusion The increase of admission NPR is an independent risk factor for septic AKI,which has a good predictive value,and high NPR is more closely related to the risk of severe AKI in septic AKI patients.NPR can predict the occurrence of septic AKI to some extent.