A bone stress injury (BSI) means that the bones cannot tolerate repeated mechanical loads, resulting in structural fatigue and local bone pain. A delay in BSI diagnosis can lead to more serious injuries, such as stress fractures that require longer treatment periods. Therefore, early detection of BSI is an essential part of management. Risk factors for BSI development include biological and biomechanical factors. Medical history and physical examination are the basics for a BSI diagnosis, and magnetic resonance imaging is helpful for confirming and grading. In this paper, the authors review the overall content of BSI and stress fractures which are common in runners. Through this review, we hope that interest in stress fractures will be raised in Korea and that active researches will be conducted.
Diagnosis ; Fatigue ; Fractures, Stress ; Hope ; Korea ; Magnetic Resonance Imaging ; Physical Examination ; Risk Factors

PURPOSE: This study aimed to understand the experiences of married North Korean women's child-rearing, working lives, and their home and work environment in depth.METHODS: This study adopted van Manen's hermeneutic phenomenological method to qualitatively analyze data. The participants were 8 married North Korean women defectors. Data were collected through in-depth interviews and observations from July 4 to August 20, 2018.RESULTS: Nine essential themes emerged: more personal challenges after overcoming a life-threatening crisis; hopes of firmly settling in this land; the wound from the north, which chased them here; a body that becomes stronger through hardship; being stuck in a past full of anxiety and pain; the present is full of hope; hope for the future; sense of alienation from coworkers that cannot be overcome; and sense of power to endure an exhausting work life.CONCLUSION: This study provided a broader understanding of the life and experiences of married women from North Korea. It highlights the need for nurses to recognize their importance in nursing care. The study also suggests that academic and practical approaches for nursing, and basic data for a nursing intervention for married women from North Korea be provided. The study findings can be used as a basis for preparing a national policy that will help North Korean defectors to find employment and gain stability.
Anxiety ; Child ; Democratic People's Republic of Korea ; Emigrants and Immigrants ; Employment ; Female ; Hermeneutics ; Hope ; Humans ; Methods ; Nursing ; Nursing Care ; Qualitative Research ; Wounds and Injuries

hope to shed light on the influence of lifestyle modifications and their clinical implications on men's health.]]>
Aging ; Hope ; Humans ; Life Style ; Male ; Men's Health ; Quality of Life ; Risk Factors ; Testosterone

This descriptive correlational study determined the level of hope and spiritual wellbeing among Filipino caregivers of terminally-ill cancer patients, and the relationship of hope and spiritual wellbeing to various patient and caregiver characteristics. The study involved 50 caregivers of terminally-ill-cancer patients, mostly belonging to 51-60 age group (42%) with mean age of 44 years (SD=15), mostly females (72%), married (62%), Roman Catholic (90%), high school graduates (50%), spouses of patients (28%), with an average of 18.36 hours of caregiving in a day for an average duration of 21.4 months. The hope and spirituality scores of caregivers were 3.24 (SD=0.28) and 3.25 (SD=0.46) respectively. Caregivers had high self-efficacy (3.29) but low social support (1.72). Patient's age was moderately correlated with caregiver's hope (r=0.3; p=0.03). Caregiver's educational attainment was significantly associated with hope (p<0.01) and spiritual wellbeing (p<0.01). Caregiver's self-efficacy was moderately correlated with their spiritual wellbeing (r=0.46, p<0.01). Caregiver's hopes were (1) for their patients to get well and recover from their illness, (2) to have strong spiritual faith and be healed with God's help (3) to be hopeful and positive, (4) hope for longer life, (5) resumption of family relations, and (6) free of pain and other discomforts. Caregivers' thoughts on spiritual wellbeing were to have: (1) stronger faith, (2) being prayerful, and (3) being positive. Compared to other studies, Filipino caregivers had lower hope scores, but higher spiritual wellbeing scores. Nursing interventions promoting hope and spiritual wellbeing should be conducted in patients' room, clinic appointments, or during home visits. Nursing care promoting hope and spiritual wellbeing should be part of patients' activities for daily living.
Humans ; Female ; Adult ; Caregivers ; Spirituality ; Family Relations ; Spouses ; Self Efficacy ; Catholicism ; Patients' ; Rooms ; House Calls ; Terminally Ill ; Hope ; Marriage ; Spiritual Therapies ; Social Support ; Neoplasms ; Pain ; Schools

BACKGROUND: The Pink peppercorn belongs to the same Anacardiaceae family as cashew and pistachio. However, the cross-reactivity of pink peppercorn with cashew and pistachio has yet to be studied. To date, there has been a single case report of anaphylaxis to pink peppercorn in a cashew and pistachio allergic individual. OBJECTIVE: We aim to demonstrate cross-sensitization to pink peppercorn in cashew and/or pistachio allergic children. METHODS: A small descriptive cohort study looking at cross-sensitization of pink peppercorn in cashew and/or pistachio allergic children was conducted. Children with a history of reaction to pistachio and/or cashew nut underwent skin prick tests to the pink peppercorn species Schinus terebinthifolius to determine cross-sensitization. RESULTS: Out of the 21 cashew and/or pistachio allergic subjects, 16 (76.2%) demonstrated cross-sensitization to pink peppercorn. None of the subjects had any knowledge of previous exposure or allergic reactions to pink peppercorn. DISCUSSION: This study demonstrates potential cross-reactivity between pink peppercorn and cashew and pistachio. While an oral food challenge to pink peppercorn would have been important in demonstrating clinical cross-reactivity, this was not performed due to ethical constraints. We hope to increase the awareness of pink peppercorn as a potential and hidden source of allergen and encourage further studies to demonstrate the clinical cross-reactivity and to better delineate the major allergen involved.
Anacardiaceae ; Anacardium ; Anaphylaxis ; Child ; Cohort Studies ; Cross Reactions ; Food Hypersensitivity ; Hope ; Humans ; Hypersensitivity ; Nuts ; Pistacia ; Skin

Objective To describe the status of hope,self-efficacy,and self-management in patients with chronic kidney disease(CKD)(stages 1-3)and to explore the interactions between these three variables.Methods Herth Hope Index,self-efficacy scale,and CKD self-management instrument were used to evaluate the patients with CKD(stages 1-3)in PUMC Hospital(=153). Structural equation modeling was used to establish the structural equation model of hope,self-efficacy,and self-management.Results The median score of hope was 40.0(36.0,44.5),and 85.0% of patients were in higher level of hope. The median score of self-efficacy was 8.3(7.1,9.4)and the overall score of self-management was 89.0±13.4. There were no significant differences in level of hope and self-management among patients with different age,gender,marital status,educational level,course of disease,and CKD stages(all >0.05). Age and marriage status were significantly associated with self-efficacy. Self-efficacy was significantly higher in >65 years group than in other age groups(<0.05)and was significantly higher in married group than in single group(<0.05).The level of hope had direct effect on self-efficacy(=0.67,<0.05)and self-management(=0.46,<0.05).Conclusions The levels of hope,self-efficacy,and self-management are high in patients with CKD(stages 1-3). Hope directly affects the self-efficacy and self-management of these patients.
Hope ; Humans ; Renal Insufficiency, Chronic ; psychology ; therapy ; Self Efficacy ; Self-Management

Guillain-Barré syndrome (GBS) is a representative form of post-infectious autoimmune neuropathy with heterogenous manifestations. It was originally considered as an ascending demyelinating polyneuropathy in Western countries. However, the discovery of anti-ganglioside antibodies on the basis of molecular mimicry theory could help us better understand various kinds of focal and regional variants as well as axonal type of GBS those were frequently found from Asian countries. Recent development of new techniques about anti-ganglioside complex antibodies is making more detailed descriptions for specific or unusual clinical manifestations. It has been regarded that GBS has good prognosis if treated properly as early as possible, but it still shows high mortality and morbidity rate with frequent long term neurologic and medical complications. Unfortunately, there are only two options for medical treatment, intravenous immunoglobulin and plasmapheresis, for the last 100 years. Several clinical studies on new immunotherapy targeting complement activating system with background of molecular mimicry using animal model are underway. We hope that these new treatments will be helpful for the future patients.
Antibodies ; Asian Continental Ancestry Group ; Axons ; Complement System Proteins ; Gangliosides ; Guillain-Barre Syndrome ; Hope ; Humans ; Immunoglobulins ; Immunotherapy ; Miller Fisher Syndrome ; Models, Animal ; Molecular Mimicry ; Mortality ; Plasmapheresis ; Polyneuropathies ; Prognosis

The survival rates of boys and men with cancer have increased due to advances in cancer treatments; however, maintenance of quality of life, including fertility preservation, remains a major issue. Fertile male patients who receive radiation and/or chemotherapy face temporary, long-term, or permanent gonadal damage, particularly with exposure to alkylating agents and whole-body irradiation, which sometimes induce critical germ cell damage. These cytotoxic treatments have a significant impact on a patient's ability to have their own biological offspring, which is of particular concern to cancer patients of reproductive age. Therefore, various strategies are needed in order to preserve male fertility. Sperm cryopreservation is an effective method for preserving spermatozoa. Advances have also been achieved in pre-pubertal germ cell storage and research to generate differentiated male germ cells from various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, and spermatogonial stem cells. These approaches offer hope to many patients in whom germ cell loss is associated with sterility, but are still experimental and preliminary. This review examines the current understanding of the effects of chemotherapy and radiation on male fertility.
Alkylating Agents ; Cryopreservation ; Drug Therapy ; Embryonic Stem Cells ; Fertility ; Fertility Preservation ; Germ Cells ; Gonads ; Hope ; Humans ; Induced Pluripotent Stem Cells ; Infertility ; Infertility, Male ; Male ; Methods ; Quality of Life ; Radiotherapy ; Spermatogenesis ; Spermatozoa ; Stem Cells ; Survival Rate ; Whole-Body Irradiation

In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human ether-à-go-go-related gene (hERG) channel known to cause QT/QTc prolongation and the QT/QTc prolongation shown on the electrocardiogram. However, these biomarkers are not the direct risks of TdP with low specificity as the action potential is influenced by multiple channels along with the hERG channel. Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative emerged to address limitations of the current model. The objective of CiPA is to develop a standardized in silico model of a human ventricular cell to quantitively evaluate the cardiac response for the cardiac toxicity risk and to come up with a metric for the TdP risk assessment. In silico working group under CiPA developed a standardized and reliable in silico model and a metric that can quantitatively evaluate cellular cardiac electrophysiologic activity. The implementation mainly consists of hERG fitting, Hill fitting, and action potential simulation. In this review, we explained how the in silico model of CiPA works, and briefly summarized current overall CiPA studies. We hope this review helps clinical pharmacologists to understand the underlying estimation process of CiPA in silico modeling.
Action Potentials ; Biomarkers ; Cardiotoxicity ; Computer Simulation ; Electrocardiography ; Hope ; Humans ; In Vitro Techniques ; Risk Assessment ; Sensitivity and Specificity ; Torsades de Pointes

PURPOSE: The purpose of this study is to explore the balance of work-life and parenting experience of nurses. METHODS: This qualitative study used the phenomenological methodology proposed by Giorgi. In-depth interviews were conducted on a total of 10 participants working at hospitals in Seoul and Gyeongnam province in 2017 to collect data. RESULTS: Four main issues were deduced: “complex situation between work and parenting,” “conflict situation of being in a double bind between work and parenting,” “the power to endure both work and parenting,” and “finding hope between work and parenting. CONCLUSION: The findings in this study provide an in-depth understanding on the work-life balance and parenting experience of nurses. These findings should help in the development of solutions to the conflict between work and family for nurses and enable them to develop effective strategies.
Hope ; Humans ; Parenting ; Parents ; Qualitative Research ; Seoul