Objective To compare the safety and efficacy of SpyGlass DS system laser lithotripsy and conventional fractional treatment under endoscopic retrograde cholangiopancreatography(ERCP)in treatment of large calculus of common bile duct.Method 38 patients with large calculus of common bile duct(>2 cm)during ERCP from November 2021 to October 2023 were selected and divided into experimental group(n=18)and control group(n=20).The experimental group was treated with SpyGlass DS system combined with laser lithotripsy.The patients in the control group were treated with split treatment(the first biliary stent was placed,and the calculus of common bile duct were removed under conventional ERCP again 3 months later).The success rate of stone clearance and the incidence of complications after ERCP were compared between the two groups.Magnetic resonance cholangiopancreatography(MRCP)was performed 3 months after surgery to determine whether there were residual calculus of common bile duct.Results The surgical time of the experimental group was longer than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the stone clearance rate and the incidence of short-term complications between the two groups(P>0.05).The incidence of long-term complications in the experimental group was lower than that in the control group,but the difference was not statistically significant(P=0.090).Conclusion SpyGlass DS guided laser lithotripsy is effective and safe for the treatment of large calculus of common bile duct,with a low recurrence rate.

Background:The overall Helicobacter pylori(Hp)infection rate in China is relatively high,with significant regional variations.Currently,there is a lack of large-sample surveys on the Hp infection rate in the general population of Xinjiang.Aims:To explore the Hp infection rate in the Xinjiang Uygur Autonomous Region and provide a reference for the prevention and control strategies of Hp infection in this region.Methods:A stratified random cluster sampling method was used to select 4 361 individuals from the general population in 15 regions of the Xinjiang Uygur Autonomous Region.Hp antibody testing was performed to assess Hp infection status.Results:The overall Hp infection rate in Xinjiang was 71.57％(3 121/4 361).The Hp infection rate showed a trend of first increasing and then decreasing with age,but the difference was not statistically significant(x2=11.992,P＞0.05).There was a statistically significant difference in the Hp infection rate among different residential areas(x2=250.316,P＜0.01).The Hp infection rates among ethnic minorities such as Uyghurs and Tajiks were significantly higher than those among Han and Hui ethnic groups,and the difference was statistically significant(x2=200.797,P＜0.01).The Hp infection rate gradually increased with the increase in altitude,and the difference was statistically significant(x2=33.366,P＜0.01).Conclusions:This study revealed that the overall Hp infection rate in Xinjiang is relatively high,with obvious differences in residential areas,ethnic groups,and altitudes.More powerful publicity and education,screening methods,and eradication strategies should be implemented for ethnic minorities in different regions.

Background:The overall Helicobacter pylori(Hp)infection rate in China is relatively high,with significant regional variations.Currently,there is a lack of large-sample surveys on the Hp infection rate in the general population of Xinjiang.Aims:To explore the Hp infection rate in the Xinjiang Uygur Autonomous Region and provide a reference for the prevention and control strategies of Hp infection in this region.Methods:A stratified random cluster sampling method was used to select 4 361 individuals from the general population in 15 regions of the Xinjiang Uygur Autonomous Region.Hp antibody testing was performed to assess Hp infection status.Results:The overall Hp infection rate in Xinjiang was 71.57％(3 121/4 361).The Hp infection rate showed a trend of first increasing and then decreasing with age,but the difference was not statistically significant(x2=11.992,P＞0.05).There was a statistically significant difference in the Hp infection rate among different residential areas(x2=250.316,P＜0.01).The Hp infection rates among ethnic minorities such as Uyghurs and Tajiks were significantly higher than those among Han and Hui ethnic groups,and the difference was statistically significant(x2=200.797,P＜0.01).The Hp infection rate gradually increased with the increase in altitude,and the difference was statistically significant(x2=33.366,P＜0.01).Conclusions:This study revealed that the overall Hp infection rate in Xinjiang is relatively high,with obvious differences in residential areas,ethnic groups,and altitudes.More powerful publicity and education,screening methods,and eradication strategies should be implemented for ethnic minorities in different regions.