Ischemic stroke is a cerebrovascular disease with high incidence and disability rates. Non-coding RNAs， as important regulatory factors for gene expression， play a key role in the development and progression of ischemic stroke， but their specific mechanisms of action remain unclear. This article systematically reviews the expression characteristics and regulatory roles of microRNAs， long non-coding RNAs， and circular RNAs in ischemic stroke and reveals the pathophysiological mechanisms of non-coding RNAs in ischemic injury by regulating the processes of cell apoptosis and autophagy， inflammatory response， blood-brain barrier integrity， and neuroregeneration. In addition， non-coding RNAs have shown the potential as biomarkers for the prediction， diagnosis， and prognostic evaluation of ischemic stroke. This article also analyzes the limitations of current research and proposes future research directions， so as to provide a theoretical foundation for exploring the mechanism of action of non-coding RNAs in ischemic stroke and developing innovative diagnostic and therapeutic strategies.
Review

BACKGROUND:Scoliosis is a three-dimensional deformity characterized by lateral bending and rotation of the spine.Its onset age covers the entire life cycle,becoming an important health issue that threatens people's health.Artificial intelligence continues to advance with the development of computer science.At present,artificial intelligence has great potential for application in medical diagnosis and treatment,and is gradually being applied in screening and diagnosis of scoliosis.OBJECTIVE:To comprehensively review the application of artificial intelligence in screening and diagnosis of scoliosis,elaborate on the progress of its application in recent years from multiple aspects,and look forward to its innovative points,providing reference for the future trend of intelligence.METHODS:Search covered databases such as PubMed,IEEE Xplore,CNKI,and WanFang,using Chinese and English search terms such as"scoliosis,artificial intelligence,machine learning,screen,diagnosis."Boolean logic was used to optimize the search strategy.Articles directly related to the application of artificial intelligence in screening and diagnosis of scoliosis were included,and articles with weak correlation,outdated experimental design,or poor credibility were excluded.Finally,83 articles were included for analysis.RESULTS AND CONCLUSION:(1)Artificial intelligence has shown unique application value and development prospects in multiple fields such as early screening of scoliosis,chest X-ray screening,smartphone screening,X-ray diagnosis,CT and MRI diagnosis,and reconstruction of three-dimensional spinal images.(2)The application of artificial intelligence in the screening and diagnosis of scoliosis has improved efficiency,reduced misdiagnosis rates,and alleviated the burden on medical staff,facilitating early detection and diagnosis of scoliosis and safeguarding spinal health.

BACKGROUND:Scoliosis is a three-dimensional deformity characterized by lateral bending and rotation of the spine.Its onset age covers the entire life cycle,becoming an important health issue that threatens people's health.Artificial intelligence continues to advance with the development of computer science.At present,artificial intelligence has great potential for application in medical diagnosis and treatment,and is gradually being applied in screening and diagnosis of scoliosis.OBJECTIVE:To comprehensively review the application of artificial intelligence in screening and diagnosis of scoliosis,elaborate on the progress of its application in recent years from multiple aspects,and look forward to its innovative points,providing reference for the future trend of intelligence.METHODS:Search covered databases such as PubMed,IEEE Xplore,CNKI,and WanFang,using Chinese and English search terms such as"scoliosis,artificial intelligence,machine learning,screen,diagnosis."Boolean logic was used to optimize the search strategy.Articles directly related to the application of artificial intelligence in screening and diagnosis of scoliosis were included,and articles with weak correlation,outdated experimental design,or poor credibility were excluded.Finally,83 articles were included for analysis.RESULTS AND CONCLUSION:(1)Artificial intelligence has shown unique application value and development prospects in multiple fields such as early screening of scoliosis,chest X-ray screening,smartphone screening,X-ray diagnosis,CT and MRI diagnosis,and reconstruction of three-dimensional spinal images.(2)The application of artificial intelligence in the screening and diagnosis of scoliosis has improved efficiency,reduced misdiagnosis rates,and alleviated the burden on medical staff,facilitating early detection and diagnosis of scoliosis and safeguarding spinal health.

Osteoarthritis(OA)is a common concern over the world.Garlic is a kind of natural herbal medicine,and its active ingredients have shown some anti-inflammatory,antioxidant,anti-catabolic,analgesic and other phar-macological effects.Garlic and its active components alleviate the inflammatory response of OA by inhibiting the ex?pression of inflammatory factors and signal pathways such as NF?κB and PI3K/Akt.They slow down the progression of OA by inhibiting the expression of extracellular matrix(ECM)degrading enzymes.Additionally,they reduce the oxidative damage of joints by upregulating the expression of antioxidant enzymes.Moreover,the active components of garlic can relieve OA pain by activating the potassium ion pathway(Kv7),ATP?sensitive potassium channel(K?ATP),and the nuclear factor erythroid 2?related factor 2(Nrf2)/heme oxygenase 1(HO?1)?NAD(P)H:qui?none oxidoreductase 1(NQO1)signaling pathway.

Phosphorylation is a common post-translational modification of specific protein 1(SP1),which can affect its transcriptional activity and DNA-binding stability by altering the structure of SP1.Phosphorylation of SP1 can promote telomere maintenance,immune escape,and production of vascular endothelial growth factor in cancer cells,promote tumor invasion and metastasis,and increase drug resistance to chemotherapy.

Objective To analyze the acupoint selection law of acupuncture and moxibustion for postherpetic neuralgia(PHN)with R language data mining technology.Methods The clinical research literature on acupuncture and moxibustion treatment of PHN included in CNKI,Wanfang Data,VIP and CBM from January 1,2010 to July 1,2023 was retrieved,and the database was established by Excel 2016.R language was used to statistically analyze the frequency of acupoint usage,meridians,locations,specific acupoints,etc.Through association rule analysis and clustering analysis,the characteristics and law of acupoint selection for acupuncture and moxibustion treatment of PHN were obtained.Results A total of 198 articles were included,including 83 acupoints,with a total frequency of 714 times.The high-frequency acupoints include Ashi acupoint,Jiaji acupoint and Yanglingquan.The commonly used meridians were gallbladder meridian,spleen meridian and large intestine meridiam.The acupoints were mostly in the upper and lower limbs,with the Wushu acupoints,Yuan acupoints and Xiahe acupoints being the most common.The core acupoint was Ashi acupoint,Jiaji acupoint,Hegu,Quchi,and 9 sets of association rules and 5 effective clusters were obtained.Conclusion The most commonly used acupoints for acupuncture and moxibustion treatment of PHN are Ashi acupoint,Jiaji acupoint,Hegu and Quchi,which mainly follow the principle of combining local acupoint selection with distal acupoint selection.

Peripheral nerve injury is a common neurodegenerative disease that affects the motor and autonomic nervous system,leading to symptoms such as weakness,constipation,and blood pressure disorders.Axon regeneration is the basis for restoring nerve function,and acupuncture can mediate axonal regeneration to treat nerve injury.This article concluded the pathways of acupuncture mediated axonal regeneration therapy for peripheral nerve injury and indicated that acupuncture could regulate growth factors,axonal guiding molecules,and internal signaling pathways of neurons to mediate axonal regeneration therapy for nerve injury,achieving the goal of peripheral nerve injury repair.This could provide references for the mechanism research of acupuncture mediated axonal regeneration therapy for peripheral nerve injury.

The key to strengthen the construction of county medical communities in China is multidimensional synergy.Based on the SFIC model,it deeply analyzes the collaborative dilemmas of county medical community in China from four dimensions:initial conditions,catalytic leadership,institutional design and collaborative process.Specifically,it is manifested as the differentiation of values among the main entities within the county medical community,the uneven catalytic leadership of each levels and entities,vertical and horizontal institutional fragmentation and weak coupling among stakeholders to collaborate.Based on typical regional experiences,for the current dilemma of collaboration in county medical community,it proposes aoptimized paths for the collaborative evolution of tightly integrated county medical community in China.

Against the backdrop of the in-depth advancement of the integration of medical treatment and disease prevention strategy and the increasingly prominent challenges in public health emergency response,it is urgently necessary to build a modern health emergency management system featuring"medical and preventive collaboration and integration".By sorting out the concept,component elements and functional positioning of the emergency management system in public hospitals,it explores the basic framework and key links of the emergency management system in public hospitals,and ensures the effective implementation of the system through multi-dimensional collaborative efforts.

Ischemic stroke(IS)is a disease caused by insufficient blood and oxygen supply to cerebral vessels,with the main clinical manifestations of hemiplegia,sensory disturbance,aphasia,and ataxia.Studies have shown that hypoxia-inducible factor 1α(HIF-1α),as the core regulatory element of oxygen homeostasis,can be rapidly activated under hypoxia/ischemia conditions,thereby playing an important role in the pathophysiology of IS.In recent years,more and more articles have shown that the active components of tradi-tional Chinese medicine,Chinese patent drugs,and compound traditional Chinese medicine prescriptions can effectively regulate the HIF-1α-related signaling pathway in the treatment of IS,but there is no systematic summary on regulation of the HIF-1α signaling pathway in the treatment of IS.Therefore,this article mainly summarizes the structure and physiological activity of HIF-1α and its mechanisms of action in IS and reviews related studies on Chinese medicine monomers and compound prescriptions in the treatment of IS in the past five years in China and globally.It is pointed out that the Chinese medicine monomers and compound prescriptions can repair brain tissue,alleviate brain tissue damage,and exert a therapeutic effect on IS by regulating the HIF-1α pathway to promote an-giogenesis,inhibit neuroinflammation and oxidative stress,promote energy metabolism,and repair blood-brain barrier damage.