Myocardial ischemia-reperfusion injury(MIRI)is a common cardiac pathological process,resulting from the combined effects of multiple mechanisms involving metabolic changes and mitochondrial dysfunction.Mitochondrial quality control(MQC),as a key regulatory mechanism,may serve as an important target for the prevention and treatment of MIRI.In recent years,traditional Chinese medicine(TCM)has demonstrated unique advantages in the field of improving MIRI,with multiple targets,multiple pathways,and low toxic and side effects.It has gained widespread clinical recognition and application.Through systematically organizing and summarizing recent studies on the targeting of MQC by monomers,active fractions,herb pairs,compound formulas and related preparations of TCM to improve MIRI,this paper finds that monomers and active fractions of TCM(such as schisandrin B,isoliquiritigenin,calenduloside E,berberine,Lycium barbarum polysaccharides and so on)as well as TCM herb pairs,compound formulas,and related preparations(couplet medicinals of Fuzi-Ganjiang,Yixin formula,Shuangshen ningxin capsule,Baijin formula,Yiqi huoxue decoction and so on),can alleviate MIRI by activating MQC to reduce oxidative stress-induced damage,promote mitochondrial biogenesis,maintain mitochondrial fission/fusion homeostasis,regulate mitochondrial autophagy,and restore mitochondrial calcium homeostasis.

Objective To evaluate the safety and efficacy of the CARTO3-based total three-dimensional(T3D,total three-dimensional)zero X-ray mapping technique in radiofrequency catheter ablation of elderly patients with atrial fibrillation. Methods A total of 60 patients diagnosed with paroxysmal atrial fibrillation underwent radiofrequency catheter ablation at the Beijing Anzhen Hospital Arrhythmia Center from December 2015 to April 2017 were included. All patients were randomly divided into the study group(30 cases) and the control group(30 cases). T3D technique was utilized in the study group, and patients in the control group received conventional AF ablation. The procedure parameters success rate of circumferential pulmonary vein isolation(CPVI), rates of atrial fibrillation recurrence complication were compared between the two groups. Results All the 60 patients with paroxysmal atrial fibrillation had successful atrial fibrillation ablation and finished follow-up. Compared with the control group, the time of atrium three-dimensional reconstruction in the study group was longer [study group vs control group:(57.7±11.0)min vs.(10.4±3.5)min,P<0.001)];X-ray exposure time was significantly shorter in the study group[study group vs control group:0 min vs.(15.73±3.91)min,(P<0.001)]. The diff erence in circumferential pulmonary vein ablation time between the two groups was not of statistical significance[study group vs. control group:(49.9 ± 11.3)min vs.(51.1 ± 12.6)min,P=0.699].CPVI was successful in all patients in both groups. There was no signifi cant diff erence in the early and late recurrence rate and the incidence of complications between the two groups(P>0.05). Conclusions The application of T3D technique in radiofrequency ablation for elderly patients with paroxysmal atrial fi brillation is safe and eff ective, which can reduce the time of X-ray exposure and has important clinical value.