Purpose: The aim of this study was to conduct a bibliometric analysis of the periodontal plastic surgery literature to identify trends, research gaps, and key themes within the field and to establish a perspective on documented research. Methods: This bibliometric study examined research outputs on mucogingival surgery indexed in the Web of Science database from 1990 to 2023. The Science Mapping Analysis Tool (SciMAT) software was used to visualize and predict research trends on this topic. Results: An analysis of publication distribution by year revealed a decline in the number of publications between 1984 and 1995, followed by an overall upward trend after 1996 despite occasional decreases. The United States contributed the most with 593 publications, and Wang HL (n=74) was the most prolific author. The most frequently used keyword was “gingival recession” (n=625). Overall, the publications received 44,859 citations, averaging 25.49 citations per publication. Conclusions Researchers have made significant efforts to improve clinical practices and procedures in periodontal plastic surgery, resulting in an increase in studies over recent years.By analyzing thematic maps and clusters—using indicators such as frequency, citations, and centrality—researchers can identify the strengths, weaknesses, and gaps in current research.

Objective: This study aimed to compare serum levels of CD163, YKL-40, and VILIP-1 between children with autism spectrum disorder (ASD) and healthy controls, while also investigating their association with the severity of ASD and language development. Methods: The study included 40 ASD-diagnosed patients (aged 18−72 months) and 40 age-matched healthy controls.Childhood Autism Rating Scale, Preschool Language Scale-4, and Ankara Development Screening Inventory were administered to children in the ASD group. Serum CD163, YKL-40 and VILIP-1 levels were measured with an enzyme-linked immunosorbent assay kit. Results: In the ASD group compared to the control group, serum VILIP-1 levels were significantly higher (p = 0.046).No significant differences were observed in mean serum CD163 and YKL-40 levels between patients and controls (p = 0.613, p = 0.769). Interestingly, a positive correlation was observed between CD163 and YKL-40 levels and ASD severity (p ＜ 0.001 for both). Additionally, CD163 and YKL-40 levels showed significant predictive value for ASD severity.While no significant associations were found between CD163 and YKL-40 levels and language development, a negative correlation was observed between VILIP-1 levels and language development (p ＜ 0.001). Conclusion Our findings highlight that the levels of CD163 and YKL-40 significantly predicted ASD severity, indicating a potential role of neuroinflammation in the development of ASD.

Objective: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder and its aetiology is not fully understood. This study aimed to determine whether the CCL5 and CCL11 influence the ADHD aetiology by comparing serum CCL5 and CCL11 levels of children with ADHD and typical development. Methods: This study included 45 (27 males, mean age = 8.9 ± 1.7 years) treatment-naive patients diagnosed with ADHD and 35 (20 males, mean age = 8.8 ± 1.6 years) healthy controls. Participants ranged in age between 6−12 years and completed the Conners Teacher Rating Scale that assesses ADHD presentation and severity. CCL5 and CCL11 serum levels were also measured using enzyme-linked immunosorbent assay kits. Results: Significantly higher serum CCL5 levels were found in children with ADHD compared to healthy controls (p ＜ 0.001). No significant difference was found between the mean serum CC11 level of the patients and controls (p = 0.93). In addition, there was no significant correlation between the serum CCL5 and CCL11 levels and predominant presentations of ADHD and disease severity. Conclusion This study suggests that there are higher levels of serum CCL5 in drug naive children with ADHD, this findings suggest that CCL5 might play a role in the pathophysiology of ADHD. Moreover, these changes in peripheral blood may have therapeutic value. In addition, these results help to understand the role of chemokines in elucidating the etiopathogenesis of ADHD. Our results can be considered as the first step in investigating the role of CCL5 in ADHD, and further research is needed to support these initial findings.