1.COVID-19 vaccine acceptance among kidney transplant recipients in Singapore.
Ian Tatt LIEW ; Hanis Abdul KADIR ; Sobhana THANGARAJU ; Quan Yao HO ; Eleanor NG ; Fiona FOO ; Terence KEE
Singapore medical journal 2025;66(2):73-80
INTRODUCTION:
A successful vaccination programme forms the cornerstone of controlling coronavirus disease 2019 (COVID-19). The unprecedented speed of COVID-19 vaccine development and lack of long-term data have raised fears regarding its safety and efficacy. Vaccine hesitancy can undermine the uptake, and hence success of the vaccination programme. Given the high complication rates of COVID-19 infections in kidney transplant recipients, it is particularly important to identify and address vaccine hesitancy in this population.
METHODS:
We conducted a cross-sectional survey among kidney transplant recipients attending transplant clinic between 5 April and 5 May 2021. The survey assessed attitudes towards COVID-19, willingness/hesitancy towards COVID-19 vaccination, vaccination concerns and prompts to vaccination. This was scored on a Likert scale with scores ranging from 'strongly disagree' - 1 point to 'strongly agree' - 5 points.
RESULTS:
One hundred and one completed responses were captured. Of these, 86% respondents reported to agree or strongly agree to vaccination. This was despite significant concerns of allograft rejection (mean score 4.12, standard deviation [SD] 0.97) and decreased immunosuppressant efficacy (mean score 4.14, SD 0.96) with vaccination. Multivariable model showed a positive association with transplant vintage of ≥ 5 years (median 2.41), lower educational levels of secondary school or less (median 5.82) and healthcare provider advocacy (median 1.88) in predicting vaccine acceptance.
CONCLUSIONS
Vaccine acceptance rate was high among kidney transplant recipients. Vaccine hesitancy remains a concern in those with a transplant vintage of less than 5 years and those with tertiary educational level. Healthcare provider advocacy is important in improving vaccine acceptance rates.
Humans
;
Kidney Transplantation
;
Singapore/epidemiology*
;
Male
;
Cross-Sectional Studies
;
Female
;
COVID-19 Vaccines
;
COVID-19/epidemiology*
;
Middle Aged
;
Adult
;
Transplant Recipients/psychology*
;
Patient Acceptance of Health Care/statistics & numerical data*
;
Vaccination Hesitancy/psychology*
;
Surveys and Questionnaires
;
Vaccination/psychology*
;
Aged
;
SARS-CoV-2
2.Mental health-related presentations to a tertiary emergency department during the COVID-19 pandemic.
Elijah Gin LIM ; Ashley Ern Hui HOW ; Julian Zhong Hui LEE ; Sameera GANTI ; Eunizar OMAR
Singapore medical journal 2025;66(12):645-650
INTRODUCTION:
The coronavirus disease 2019 (COVID-19) pandemic has caused significant mental distress in populations globally. At the frontline of the pandemic, emergency departments (EDs) are the prime setting to observe the effects of the pandemic on the mental health of the population. We aimed to describe the trend of mental health-related ED attendances at an acute hospital in Singapore before and during the various stages of the COVID-19 pandemic.
METHODS:
This is a retrospective, descriptive study of patients who presented to the ED between 1 January 2019 and 31 December 2020. Patients diagnosed with mental health-related systematised nomenclature of medicine who visited the ED during this period were identified and were placed into mental health diagnosis categories for analysis. A comparison was made between patients who presented before the pandemic (2019) and during the pandemic (2020).
RESULTS:
During the study periods, we identified 1,421 patients, of whom 27 were excluded due to non-mental health-related diagnoses, leaving 1,394 patients for analysis. There was a 36.7% increase in mental health-related ED presentations from 2019 to 2020. The proportion of higher-acuity mental health-related ED attendances and number of suicide attempts also increased.
CONCLUSION
Our study described an increase in the proportion of high-acuity mental health-related ED attendances during the COVID-19 pandemic. Emergency physicians must be cognisant of the effects of the pandemic on mental health. Further research should be conducted to better equip the healthcare system for handling all aspects of the pandemic.
Humans
;
COVID-19/psychology*
;
Emergency Service, Hospital/statistics & numerical data*
;
Retrospective Studies
;
Singapore/epidemiology*
;
Male
;
Female
;
Adult
;
Middle Aged
;
Mental Disorders/diagnosis*
;
Mental Health
;
SARS-CoV-2
;
Tertiary Care Centers
;
Pandemics
;
Aged
;
Suicide, Attempted/statistics & numerical data*
;
Young Adult
;
Adolescent
3.Impact of early detection and management of emotional distress on length of stay in non-psychiatric inpatients: A retrospective hospital-based cohort study.
Wanjun GUO ; Huiyao WANG ; Wei DENG ; Zaiquan DONG ; Yang LIU ; Shanxia LUO ; Jianying YU ; Xia HUANG ; Yuezhu CHEN ; Jialu YE ; Jinping SONG ; Yan JIANG ; Dajiang LI ; Wen WANG ; Xin SUN ; Weihong KUANG ; Changjian QIU ; Nansheng CHENG ; Weimin LI ; Wei ZHANG ; Yansong LIU ; Zhen TANG ; Xiangdong DU ; Andrew J GREENSHAW ; Lan ZHANG ; Tao LI
Chinese Medical Journal 2025;138(22):2974-2983
BACKGROUND:
While emotional distress, encompassing anxiety and depression, has been associated with negative clinical outcomes, its impact across various clinical departments and general hospitals has been less explored. Previous studies with limited sample sizes have examined the effectiveness of specific treatments (e.g., antidepressants) rather than a systemic management strategy for outcome improvement in non-psychiatric inpatients. To enhance the understanding of the importance of addressing mental health care needs among non-psychiatric patients in general hospitals, this study retrospectively investigated the impacts of emotional distress and the effects of early detection and management of depression and anxiety on hospital length of stay (LOS) and rate of long LOS (LLOS, i.e., LOS >30 days) in a large sample of non-psychiatric inpatients.
METHODS:
This retrospective cohort study included 487,871 inpatients from 20 non-psychiatric departments of a general hospital. They were divided, according to whether they underwent a novel strategy to manage emotional distress which deployed the Huaxi Emotional Distress Index (HEI) for brief screening with grading psychological services (BS-GPS), into BS-GPS ( n = 178,883) and non-BS-GPS ( n = 308,988) cohorts. The LOS and rate of LLOS between the BS-GPS and non-BS-GPS cohorts and between subcohorts with and without clinically significant anxiety and/or depression (CSAD, i.e., HEI score ≥11 on admission to the hospital) in the BS-GPS cohort were compared using univariable analyses, multilevel analyses, and/or propensity score-matched analyses, respectively.
RESULTS:
The detection rate of CSAD in the BS-GPS cohort varied from 2.64% (95% confidence interval [CI]: 2.49%-2.81%) to 20.50% (95% CI: 19.43%-21.62%) across the 20 departments, with a average rate of 5.36%. Significant differences were observed in both the LOS and LLOS rates between the subcohorts with CSAD (12.7 days, 535/9590) and without CSAD (9.5 days, 3800/169,293) and between the BS-GPS (9.6 days, 4335/178,883) and non-BS-GPS (10.8 days, 11,483/308,988) cohorts. These differences remained significant after controlling for confounders using propensity score-matched comparisons. A multilevel analysis indicated that BS-GPS was negatively associated with both LOS and LLOS after controlling for sociodemographics and the departments of patient discharge and remained negatively associated with LLOS after controlling additionally for the year of patient discharge.
CONCLUSION
Emotional distress significantly prolonged the LOS and increased the LLOS of non-psychiatric inpatients across most departments and general hospitals. These impacts were moderated by the implementation of BS-GPS. Thus, BS-GPS has the potential as an effective, resource-saving strategy for enhancing mental health care and optimizing medical resources in general hospitals.
Humans
;
Retrospective Studies
;
Male
;
Length of Stay/statistics & numerical data*
;
Female
;
Middle Aged
;
Adult
;
Psychological Distress
;
Inpatients/psychology*
;
Aged
;
Anxiety/diagnosis*
;
Depression/diagnosis*
4.Factors influencing mask-wearing behavior in the context of COVID-19 severity risks in the post-COVID-19 era: a Japanese Nationwide Epidemiological Survey in 2023.
Shingo NOGUCHI ; Tomohiro ISHIMARU ; Kazuhiro YATERA ; Yoshihisa FUJINO ; Masayoshi ZAITSU ; Takahiro TABUCHI
Environmental Health and Preventive Medicine 2025;30():41-41
BACKGROUND:
Although the global COVID-19 mortality rate is decreasing, COVID-19 remains an infectious disease with a high mortality rate, especially in older adults and individuals with comorbidities. In Japan, mask-wearing has been left to individual discretion since March 13, 2023, but remains a key protective measure. This study aimed to identify factors influencing individual mask-wearing behavior in post COVID-19 era, with a focus on risk factors for severe COVID-19.
METHODS:
Data from 33,000 participants, obtained from the Japan COVID-19 and Society Internet Survey 2023, were used, which was conducted from September 25 to November 17, 2023. Participants were randomly selected from approximately 2.2 million panelists from a nationwide Japanese Internet research company, with sampling adjusted by age, sex, and living area to match the population distribution in Japan. The association between wearing a mask and risk factors for severe COVID-19 (age, sex, smoking, COVID-19 vaccination, history of COVID-19, body mass index (BMI), and comorbid conditions) was evaluated using univariate and multivariate analyses.
RESULTS:
In total, 28,481 individuals were included, of whom 18,371 (64.5%) answered that they wore masks. After adjusting for confounders, older age (adjusted relative risk [RR], 1.50; 95% confidence interval [CI], 1.45-1.55 for "75-83" years), no history of COVID-19 (adjusted RR, 1.06; 95% CI, 1.04-1.08), low BMI (adjusted RR, 1.04; 95% CI, 1.02-1.07), and increased number of comorbid conditions (adjusted RR, 1.11; 95% CI, 1.05-1.18 for three or more) were significant positive factors for wearing a mask. In contrast, men (adjusted RR, 0.89; 95% CI, 0.87-0.90), no COVID-19 vaccination (adjusted RR, 0.78; 95% CI, 0.76-0.81), and current smoking history (adjusted RR, 0.96; 95% CI, 0.93-0.99) were significant negative factors.
CONCLUSION
We demonstrated that mask-wearing behavior differed based on individual risk factors for severe COVID-19, with some risk factors negatively influencing mask use in Japan. It may be necessary to recommend mask-wearing for these individuals, especially during situations such as COVID-19 epidemic season or the onset of epidemics, considering individual mask-wearing behavior.
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Female
;
Humans
;
Male
;
Middle Aged
;
Young Adult
;
COVID-19/psychology*
;
Japan/epidemiology*
;
Masks/statistics & numerical data*
;
Risk Factors
;
Surveys and Questionnaires
;
East Asian People
5.Association between levels of satisfaction with interpersonal relationships and insomnia symptoms among women working in aged-care services in Japan.
Ryuichiro WATANABE ; Ai IKEDA ; Hadrien CHARVAT ; Setsuko SATO ; Yuka SUZUKI ; Koutatsu MARUYAMA ; Kiyohide TOMOOKA ; Hiroo WADA ; Yasunari KOYAMA ; Takeshi TANIGAWA
Environmental Health and Preventive Medicine 2025;30():47-47
BACKGROUND:
The demand for aged-care services in Japan has surged due to the country's aging population. Furthermore, nationwide survey on the current state of aged-care services revealed that the primary reason for the resignation of women working in these sectors was poor interpersonal relationships. Moreover, given that women working in aged-care services work in shifts around the clock to manage the health and safety of the people in their care, they are at high risk of health-related issues including insomnia symptoms. Thus, we aim to examine the association between levels of satisfaction with interpersonal relationships (LSIR) and insomnia symptoms for women working in aged-care services in Japan, as well as the effect of work-life imbalance on the association between LSIR and insomnia symptoms.
METHODS:
In this cross-sectional study, the participants were 472 women aged 18-60 years who worked in aged-care services in Japan in 2014-2016. Insomnia symptoms were measured using the Athens Insomnia Scale, and scores of 6 or greater indicated the presence of insomnia. LSIR were assessed through self-administered questionnaires and evaluated at three levels. The association between LSIR and insomnia symptoms was evaluated using a multinominal logistic regression model. Path analysis was used to examine the potential effects of LSIR on insomnia symptoms by incorporating covariates such as work-family conflict, marital status, and depressive symptoms.
RESULTS:
Compared to high LSIR, the multivariable-adjusted odds ratios (95% confidence interval) of insomnia symptoms were respectively 1.36 (0.81-2.30) and 2.42 (1.11-5.23) for medium and low LSIR. The path analysis showed that low LSIR were significantly associated with having high work-to-family (W-to-F) conflict and being single.
CONCLUSIONS
Low LSIR were significantly associated with insomnia symptoms among women working in aged-care services in Japan. High W-to-F conflict exacerbated this relationship. Therefore, enhancing interpersonal relationships may be necessary for preventing insomnia. However, due to the cross-sectional nature of our study, causality cannot be inferred. Further longitudinal research is needed to better understand these associations.
Humans
;
Japan/epidemiology*
;
Sleep Initiation and Maintenance Disorders/psychology*
;
Female
;
Middle Aged
;
Adult
;
Cross-Sectional Studies
;
Interpersonal Relations
;
Young Adult
;
Adolescent
;
Personal Satisfaction
;
Health Services for the Aged/statistics & numerical data*
6.Family eating and activity habits: a comparison of nutrition among nurses and non-health professionals in the Arab ethnic minority in Israel.
Aia BUSNAN ; Miriam THEILLA ; Anat AMIT AHARON
Environmental Health and Preventive Medicine 2025;30():94-94
BACKGROUND:
Obesity and diabetes constitute significant health concerns within the Arab population in Israel. The study examines food literacy and self-assessed nutritional variables, which may explain family eating and activity habits among the Arab ethnic minority in Israel. The study examines these variables among professional nurses, who are expected to advocate for healthy behaviors within the population, compared to non-health professionals.
METHODS:
A cross-sectional study compared two groups: professional nurses and non-health professionals. A closed, structured self-report questionnaire (with five sub-sections) assessed food literacy, self-assessed nutrition, and family eating and activity habits. Data was collected between January and May 2022. A MANCOVA was used to compare the research variables among nurses and non-health professionals, and η2 was calculated as the effect size. A multiple linear regression was conducted to examine the variables explaining families' eating and activity habits. The model's significance and variance explained (R2) were calculated.
RESULTS:
The study included 213 Israeli Arab participants (103 nurses and 110 non-health professionals). Nurses showed poorer self-assessed nutrition and family eating/activity habits than non-health professionals. Regression analysis identified profession (β = -0.39, p < 0.001), gender (β = 0.22, p < 0.001), BMI (β = -0.22, p < 0.001), food literacy (β = 0.20 p < 0.001), and self-assessed nutrition (β = 0.30, p < 0.001) as significant predictors of family eating and activity habits. The model was significant (p < 0.001) and explained 38.0% of the variance.
CONCLUSION
Despite their health education background, Arab nurses reported suboptimal nutritional behaviors and unhealthy lifestyles that impact their family lifestyle practices, potentially hindering their health and limiting their effectiveness as health role models. Policymakers should develop ongoing nutrition health promotion programs tailored to the Arab nurses and Arab ethnic minority communities in Israel.
Humans
;
Israel
;
Female
;
Male
;
Arabs/psychology*
;
Adult
;
Cross-Sectional Studies
;
Nurses/statistics & numerical data*
;
Middle Aged
;
Feeding Behavior
;
Minority Groups/statistics & numerical data*
;
Exercise
;
Nutritional Status
;
Family
;
Young Adult
7.Prehospital factors influencing patients' injury severity score who fell from height.
Journal of Peking University(Health Sciences) 2024;56(6):1065-1068
OBJECTIVE:
To analyze the clinical characteristics of patients with severe fall injury and explore the prehospital factors affecting the injury severity score (ISS).
METHODS:
Clinical data of severe trauma patients with fall injury and ISS≥16 from January 2018 to December 2020 were retrieved from trauma database of Peking University People' s Hospital. The patients' age, gender, suicidal tendencies, psychiatric disorders, fall height, properties of the impact surface, the body part hitting the ground, abbreviated injury scale, Glasgow coma scale (GCS), length of stay in intensive care unit (ICU), operation were collected. And the in-hospital mortality were calculated. Univariate analysis and multiple linear regression models were used to analyze the relationship between the above factors and ISS. The patients' GCS, length of stay in ICU, surgery, and in-hospital mortality were collected to analyze the general clinical characteristics of patients.
RESULTS:
A total of 160 patients were finally eligible, including 138 males and 22 females, with an average age of (45.56±15.85) years. Among the 160 patients, there were 36 cases (22.50%) with suicidal tendencies, 12 cases (7.50%) with psychiatric disorders. Their average fall height was (7.20±8.33) meters, and 48 cases (30.00%) hit the soft contact medium. 40 cases (25.00%) with impact on the head at the ground, lower limbs in 26 cases (16.25%), ventral in 16 cases (10.00%), dorsal in 40 cases (25.00%), lateral in 38 cases (23.75%). The patients' ISS was 22.8±6.85, GCS was 13.49±3.39, lengths of ICU stays were (9.96±8.12) days, and 142 (88.75%) patients underwent surgery, 8 in-hospital deaths were all due to head trauma, with an in-hospital mortality rate of 5.00%. Univariate analysis suggested that the main factors influencing ISS were the presence of suicidal tendencies (P=0.01) and the site of impact on the ground (P=0.02). Multiple linear regression analysis indicated that suicidal tendencies and head impact on the ground were in-fluential factors for high ISS.
CONCLUSION
Collecting prehospital information of patients with fall injuries, such as whether they have suicidal tendencies and whether they hit the ground with their heads, can effectively predict the severity of patients' injuries, which is conducive to early diagnosis, early care, and early treatment, thus reducing preventable death.
Humans
;
Male
;
Female
;
Middle Aged
;
Injury Severity Score
;
Hospital Mortality
;
Adult
;
Accidental Falls/statistics & numerical data*
;
Glasgow Coma Scale
;
Intensive Care Units
;
Length of Stay/statistics & numerical data*
;
Wounds and Injuries/psychology*
;
Abbreviated Injury Scale
9.Resident involvement in the prostatic urethral lift: implementing innovative technology in an academic setting.
Ridwan ALAM ; Matthew J RABINOWITZ ; Taylor P KOHN ; Vanessa N PEÑA ; James L LIU ; Yasin BHANJI ; Amin S HERATI
Asian Journal of Andrology 2021;23(6):616-620
Adoption of the prostatic urethral lift (PUL) as a treatment for benign prostatic hyperplasia highlights the importance of training residents with novel technology without compromising patient care. This study examines the effect of resident involvement during PUL on patient and procedural outcomes. Retrospective chart review was conducted on all consecutive PUL cases performed by a single academic urologist between October 2017 and November 2019. Trainees in post-graduate year (PGY) 1-3 are considered junior residents, while those in PGY 4-6 are senior residents. The International Prostate Symptom Score (IPSS) and quality of life (QOL) scores were used to measure outcomes. Simple and mixed-effects linear regression models were used to compare differences. There were 110 patients with a median age of 66.4 years. Residents were involved in 73 cases (66.4%), and senior residents were involved in 31 of those cases. Resident involvement was not associated with adverse perioperative outcomes with respect to the number of implants fired, the percentage of implants successfully placed, or the postoperative catheterization rate. After adjustment for confounding factors, junior residents were associated with significantly longer case length compared to the attending alone (+12.6 min, P = 0.003) but senior residents were not (+2.4 min, P = 0.59). IPSS and QOL scores were not significantly affected by resident involvement (P = 0.12 and P = 0.21, respectively). The presence of surgeons-in-training, particularly those in the early stages, prolongs PUL case length but does not appear to have an adverse impact on patient outcomes.
Aged
;
Humans
;
Internship and Residency/statistics & numerical data*
;
Male
;
Middle Aged
;
Prostate/surgery*
;
Prostatic Hyperplasia/surgery*
;
Quality of Life/psychology*
;
Retrospective Studies
;
Treatment Outcome
;
Ureteroscopy/statistics & numerical data*
10.Association between high psychological distress and poor oral health-related quality of life (OHQoL) in Japanese community-dwelling people: the Nagasaki Islands Study.
Ai SEKIGUCHI ; Shin-Ya KAWASHIRI ; Hideaki HAYASHIDA ; Yuki NAGAURA ; Kenichi NOBUSUE ; Fumiaki NONAKA ; Hirotomo YAMANASHI ; Masayasu KITAMURA ; Koji KAWASAKI ; Hideki FUKUDA ; Takahiro IWASAKI ; Toshiyuki SAITO ; Takahiro MAEDA
Environmental Health and Preventive Medicine 2020;25(1):82-82
BACKGROUND:
We investigated the association between psychological distress and oral health status/oral health-related quality of life (OHQoL) in Japanese community-dwelling people.
METHODS:
We conducted a cross-sectional study using data from the Nagasaki Islands Study. A total of 1183 (455 men and 728 women) has been analyzed in this study. Psychological distress was measured using the Kessler Psychological Distress Scale (K6). Oral health status was measured by dental examination. The OHQoL was measured using the General Oral Health Assessment Index (GOHAI). We defined the total score of ≥5 points on the K6 as high psychological distress (high-K6 group).
RESULTS:
The multiple linear regression analysis to identify the GOHAI showed that gender, K6, the total number of teeth, the number of dental caries, and visiting a dental clinic within the past 6 months significantly associated with the GOHAI. Among all of these variables, high-K6 (≥ 5) was a substantial contributing factor of the GOHAI (β = - 0.23, 95% Cl - 2.31 to -1.41, p < 0.0001).
CONCLUSIONS
It is likely that the individual with high psychological distress was strongly related to poor OHQoL even in the general population.
Aged
;
Cross-Sectional Studies
;
Dental Caries/epidemiology*
;
Female
;
Humans
;
Independent Living/statistics & numerical data*
;
Japan/epidemiology*
;
Linear Models
;
Male
;
Middle Aged
;
Oral Health/statistics & numerical data*
;
Quality of Life/psychology*
;
Sex Factors
;
Stress, Psychological/epidemiology*

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