Chonnam Medical Journal  2019;55(2):86-98

doi:10.4068/cmj.2019.55.2.86

Recent Advances in Biosensors for Nucleic Acid and Exosome Detection

Zirui FU 1 ; Yi Cheng LU ; James J LAI

Affiliations

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Keywords

Biosensing Techniques; Optical Biosensors; Electrochemical Biosensors; Exosomes; Nucleic Acids

Country

Republic of Korea

Language

English

Abstract

Biosensors are analytical devices for biomolecule detection that compromise three essential components: recognition moiety, transducer, and signal processor. The sensor converts biomolecule recognition to detectable signals, which has been applied in diverse fields such as clinical monitoring, in vitro diagnostics, food industry etc. Based on signal transduction mechanisms, biosensors can be categorized into three major types: optical biosensors, electrochemical biosensors, and mass-based biosensors. Recently, the need for faster, more sensitive detection of biomolecules has compeled researchers to develop various sensing techniques. In this review, the basic structure and sensing principles of biosensors are introduced. Additionally, the review discusses multiple recent works about nucleic acid and exosome sensing.