Chinese Journal of Clinical Medicine 2025;32(1):41-45

doi:10.12025/j.issn.1008-6358.2025.20250023

Application of Yttrium-90 microsphere selective internal radiation therapy in downstaging and conversion of hepatocellular carcinoma: a case report

Ziwei LIANG 1 ; Tiantian ZHANG 1 ; Yong LIAO 2 ; Xin HUANG 2 ; Bin LIANG 3 ; Zhongbin HANG 4 ; Yan ZHANG 5 ; Lin ZHANG 2 ; Xiaobin FENG 2 ; Li HUO 6

Affiliations

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Keywords

hepatocellular carcinoma; Yttrium-90; downstaging; conversion

Country

China

Language

Chinese

Abstract

This case report describes a 68-year-old male patient diagnosed with primary hepatocellular carcinoma (HCC). After receiving Yttrium-90 microsphere selective internal radiation therapy (90Y-SIRT), the tumor significantly reduced in size, and tumor markers alpha fetoprotein (AFP) and abnormal prothrombin (PIVKA-Ⅱ) decreased. Postoperative pathological results showed minimal residual tumor cells, indicating that 90Y-SIRT has good efficacy and safety in downstaging and conversion of HCC, thereby facilitating subsequent surgical resection.