Journal of International Oncology 2013;40(9):678-680
doi:10.3760/cma.j.issn.1673-422X.2013.09.012
Molecular targeted therapy for breast cancer patients based on Notch signal transduction pathway
Yongqu ZHANG ; Xiaowei DOU ; Guojun ZHANG
Keywords
Breast neoplasms; Notch signal transduction pathway; Molecular targeted therapy
Country
China
Language
Chinese
Abstract
Studies show that the Notch signal transduction pathway involves in the regulation and control of cell proliferation,differentiation and apoptosis.Aberrant Notch signaling transduction pathway can induce breast cancer in transgenic mice.High expressions of either Notch receptors or their ligands have been linked to poor prognosis in patients with breast cancer.Inhibition of Notch signal transduction pathway may be beneficial for breast cancer treatment.
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