Objective To investigate the etiological factors of hepatic dysfunction during late gestational period,and explore its effect on the mothers and babies.Methods The causes and prognosis of 347 cases with hepatic dysfunction during gestational period were retrospectively analyzed.Result Of the 347 cases of pregnancy,viral hepatitis was present in 216 cases(62.2%),and intrahepatic cholestasis of pregnancy(ICP) present in 80 cases(23.1%);Postpartum hemorrhage rate increased significantly in viral hepatitis,and the rates of premature birth,fetal distress in uterus and cesarean increased obviously in ICP.Conclusion Viral hepatitis and ICP were the main causes of hepatic dysfunction,different complicated diseases may increase the danger of the mother and baby during pregnancy and childbirth.