Chinese Journal of Biotechnology 2010;26(9):1187-1198

Transcriptome platforms and applications to metabolic engineering.

Shuobo SHI 1 ; Tao CHEN ; Xueming ZHAO

Affiliations

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Country

China

Language

Chinese

Abstract

Omics technologies have profoundly promoted development and applications of metabolic engineering by analysis of cell metabolism at a system level. Whole genome transcription profiles have provided researchers more rigorous evaluation of cell phenotype and an increased understanding of cellular metabolism. Furthermore, transcriptome analysis can conduce to identification of effective gene targets for strain improvement, and consequently accelerates rational design and construction of microbial cell factories for desired product. In this review, we briefly introduced the principle of three main platforms of transcriptome, and reviewed the recent applications of the transcriptome to metabolic engineering, finally provided conclusions and future prospects.