International Neurourology Journal  2015;19(1):34-38

doi:10.5213/inj.2015.19.1.34

Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice.

Seheon JUNG 1 ; Sun Ouck KIM ; Kyung Aa CHO ; Seung Hee SONG ; Teak Won KANG ; Kwangsung PARK ; Dongdeuk KWON

Affiliations

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Keywords

Aquaporin 1; Caveolin 1; Bladder

Country

Republic of Korea

Language

English

Abstract

PURPOSE: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder. METHODS: The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques. RESULTS: Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05). CONCLUSIONS: The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.