Tropical Biomedicine  2019;36(2):357-366

Dengue protease inhibition activity of selected Malaysian medicinal herbs

Salleh, H.M. 1 ; Chong, S.-L. 1 ; Othman, R. 2 ; Hazni, H. 3 ; Ahmad, K. 4 ; Mohd Yusof, M.Y.Z. 4 ; Fauzi, N.W. 5 ; Wahab, H.A. 6 ; Liew, S.Y. 7 ; Awang, K. 1

Affiliations

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Country

Malaysia

Language

English

Abstract

Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 μg/mL with IC50 value of 0.30 ± 0.16 μg/mL.