Academic Journal of Xi'an Jiaotong University  2004;25(3):209-212

Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10.

Qing Yin ZHENG 1 ; Belinda S HARRIS ; Patricia F WARD-BAILEY ; Heping YU ; Roderick T BRONSON ; Muriel T DAVISSON ; Kenneth R JOHNSON

Affiliations

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Country

China

Language

English

Abstract

OBJECTIVE: to map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. METHODS: genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. RESULTS: 1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area.