Korean Journal of Pediatric Infectious Diseases  2014;21(2):150-156

Neonatal Meningoencephalitis caused by Herpes Simplex Virus Type 2.

Dae Eun KIM ; Ramee PAE ; E Young BAE ; Ji Yoon HAN ; Seung Beom HAN ; Dae Chul JEONG ; In Goo LEE ; Jin Han KANG

Keywords

Herpes Simplex Virus Type 2; Meningoencephalitis; Neonate; Republic of Korea

Country

Republic of Korea

Language

English

Abstract

Despite its rare occurrence, early diagnosis and appropriate treatment for neonatal herpes simplex virus infection are mandatory due to its high morbidity and mortality. In Korea, there has been no epidemiologic data on neonatal herpes simplex virus infection, and even case reports are rare. We observed a 16-day-old neonate who presented with fever and seizures. We diagnosed her with meningoencephalitis caused by herpes simplex virus type 2 based on the polymerase chain reaction test, and treated her with intravenous acyclovir and anticonvulsants. The seroprevalence of herpes simplex virus type 2 sharply increases in women in their 30s, and the average age for childbirth has increased to older than 30 years of age in Korea; we therefore expect that the incidence of neonatal herpes simplex virus type 2 infection will rise in Korea, and more attention should be directed to neonatal herpes simplex virus type 2 infection. We report this newborn patient's case along with a literature review.