Philippine Journal of Pathology 2023;8(1):42-48

doi:doi.org/10.21141/PJP.2023.02

RUNX1::RUNX1T1 Fusion in Pediatric Acute Myeloid Leukemia: A description of two cases.

Jill Jaime 1 ; Ivy Mae Medalla 2 ; Steffanie Charlyne Tamayo 3 ; Qareem Pido 1 ; Francisco Tria IV 4 ; Ma. Luisa Enriquez 3 ; Jean Kamil Sy 1 ; Reynaldo De Castro Jr. 1 ; Daphne Ang 4

Affiliations

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Keywords

Pediatric acute myeloid leukemia; Berlin- Frankfurt-Münster (BFM-87) protocol; l,AML 15 Medical Research Council protocol

Country

Philippines

Language

English

Abstract

RUNX1::RUNX1T1 is a core-binding factor driving fusion gene which arises from t(8;21)(q22;q22). It is one of the most common chromosomal rearrangements in both pediatric and adult Acute Myeloid Leukemia (AML) with a reported incidence o 15% in children and young adults. There are few case reports documenting RUNX1::RUNX1T1 translocation in pediatric AML. Although this is generally associated with a favorable prognosis, we report two (2) cases of de novo pediatric AML in the Philippines harboring a RUNX1::RUNX1T1 translocation, one eventually relapsed while the other attained remission but succumbed to sepsis.