Objective To establish a HPLC method for determining the contents of Magnolol and Honokiol in Weikang Capsule.Methods Stationary phase was Hypersil ODS C_(18)(4.6mm?100mm,5?m),mobile phase was methanol-water(70:30),with detection wavelength 294 nm,flow rate 1.0mL/min and column temperature 30℃.Results There was good linearity in range of 0.0534～1.068?g(r=0.9998,n=6)for Magnolol.The average recoveries of Magnolol was 99.08%,RSD was 0.57%.There was good linearity in range of 0.09～1.80?g(r=0.9998,n=6)for Honokiol.The average recoveries of Honokiol was 98.95%,RSD was 0.69%.Conclusion This method is simple,fast and accurate for the quality control of the preparation.