Japanese Journal of Complementary and Alternative Medicine  2017;14(1):9-16

doi:10.1625/jcam.14.9

Effects of Crocetin on the Pupillary Response during Accommodation Induced by Visual Display Terminal Work: A Randomized, Double-blind, Placebo-controlled, Crossover Trial

Naofumi UMIGAI ; Tadahiro SAITO ; Shin-ichiro YAMASHITA ; Naoko SUZUKI ; Takahiro YAMADA

Keywords

Crocetin; Eye fatigue; VDT work; Accommodation

Country

Japan

Language

Japanese

Abstract

The purpose of this study was to examine the effects of crocetin on the pupillary response during accommodation induced by visual display terminal (VDT) work. This clinical study was conducted as a randomized, double-blind, placebo-controlled, crossover trial in healthy adult volunteers with subjective symptoms of eye fatigue. In this study, the pupillary response during accommodation was evaluated using pupil constriction ratio (PCR). PCR was measured before and after VDT work, after rest at baseline, and at each intervention period. Following analysis of variations in PCR, the variation in PCR after rest significantly increased in the crocetin group. According to the visual analog scale questionnaire, subjective symptoms of eye fatigue significantly improved. These results show that ingestion of crocetin for 4 weeks is effective in mitigating the pupillary response during accommodation associated with VDT work.